Kristian Stengaard-Pedersen

The D‐vitamin metabolite 1,25(OH)2D in serum is associated with disease activity and Anti‐Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients

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DOI

  • Mette Herly, Reumatologisk Afdeling, Odense Universitetshospital
  • ,
  • Kristian Stengaard-Pedersen
  • Peter Vestergaard, Clinical Institute, Aalborg University, Aalborg, Denmark Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark., Denmark
  • Mikkel Østergaard, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark., Denmark
  • Peter Junker, Reumatologisk Afdeling, Odense Universitetshospital, Denmark
  • Merete Lund Hetland, Univ Copenhagen, University of Copenhagen, Glostrup Hosp, Dept Ophthalmol, Glostrup Cty Hosp, University of Copenhagen, Danish Rheumatol Database DANBIO, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci, Denmark
  • Kim Horslev-Petersen, King Christian X Hosp Rheumat Dis, Res Unit, Univ Southern Denmark, University of Southern Denmark, Inst Mol Med, Denmark
  • Torkell Juulsgaad Ellingsen, Reumatologisk Afdeling, Odense Universitetshospital

Rationale: Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA). Most studies investigate only 25OHD and not the physiologically active vitamin D metabolite, 1,25(OH) 2D. Objective: To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment naïve early RA patients. Serum level of vitamin D metabolites (25OHD 2, 25OHD 3 and 1,25(OH) 2D) was measured by isotope dilution mass spectrometry and radio-immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS28-CRP, HAQ, VAS-scores, CRP, erosive status (Total Sharp Score; TSS), ACPA and IgM-RF-status. Associations were evaluated using Spearman's and Wilcoxon rank-sum tests. The study was registered in clinical trials; trial registration number: NCT00209859. Findings: Statistically significant inverse associations were found between the active metabolite 1,25(OH) 2D and DAS28-CRP (P = 0.004, rho = −0.23), HAQ (P = 0.005, rho = −0.22), CRP (P = 0.001, rho = −0.25), VAS patient-pain (P = 0.008, rho = −0.21), and a positive association was found to ACPA-status (P = 0.04). Conclusion: The vitamin D metabolite 1,25(OH) 2D was inversely associated with disease activity and positively associated with ACPA in treatment naïve and inflammatory active early RA. The results indicate that in RA, both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect—or might be affected by the level of vitamin 1,25(OH) 2D.

Original languageEnglish
Article numbere12704
JournalScandinavian Journal of Immunology
Volume88
Issue3
Number of pages9
ISSN0300-9475
DOIs
Publication statusPublished - Sep 2018

    Research areas

  • 1,25-DIHYDROXYVITAMIN D-3, 25-HYDROXYVITAMIN D, ACTIVATION, BONE LOSS, CYTOKINES, D ASSAYS, D-RECEPTOR, PHYSICAL-ACTIVITY, RISK, T-CELLS

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