Kristian Stengaard-Pedersen

Radiographic progression and remission rates in early rheumatoid arthritis - MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial

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  • Merete L Hetland, Denmark
  • Kristian Stengaard-Pedersen
  • Peter Junker, Denmark
  • Mikkel Ostergaard, Denmark
  • Bo J Ejbjerg, Denmark
  • Søren Jacobsen, Denmark
  • Tine Lottenburger, Denmark
  • Ib Hansen
  • Ulrik Tarp, Denmark
  • Lis S Andersen, Denmark
  • Anders Svendsen, Denmark
  • Jens K Pedersen, Denmark
  • Ulrik B Lauridsen, Denmark
  • Torkell Ellingsen, Denmark
  • Hanne Lindegaard, Denmark
  • Jan Pødenphant, Denmark
  • Aage Vestergaard, Denmark
  • Anne Grethe Jurik
  • Kim Hørslev-Petersen, Denmark
  • the CIMESTRA study group
  • Diagnostic Radiology
  • The Section for Rheumatology
OBJECTIVE: /st> At 5 years' follow-up of early (<6 months) rheumatoid arthritis patients to (1) investigate whether initial combination therapy with methotrexate (MTX) and ciclosporin (CSA) (n=80) is superior to initial monotherapy with MTX (n=80) with respect to prevention of radiographic progression, (2) investigate whether the favourable clinical and radiographic response reported at 2 years in the CIMESTRA trial can be maintained and (3) identify predictors of radiographic outcome. METHODS: /st> 139 patients completed 5 years' follow-up with maintained double-blinding and a strict synovitis suppressive treatment strategy with intra-articular betamethasone injections (intra-articular glucocorticosteroid (GC)) and escalation of disease-modifying anti-rheumatic drug treatment. Disease activity, total Sharp-van der Heijde Score (TSS) of hands, wrists and forefeet were assessed at baseline and after 3, 4 and 5 years. MRI of the wrist and anti-cyclic citrullinated peptide (anti-CCP) were assessed at baseline. RESULTS: /st> At 5 years, TSS progression rate was <1 unit/year and 47% had not progressed radiographically since baseline. 78% were in Disease Activity Score remission, 56% in American College of Rheumatology remission and 17% withdrawn from treatment due to remission. There were no differences between initial treatment groups. MRI-bone marrow oedema, TSS and anti-CCP predicted radiographic progression at 5 years. CONCLUSION: /st> Early and strict synovitis suppressive treatment with MTX and intra-articular GC lead to high remission rates and halting of erosive progression at 5 years. No additional effect of initial combination therapy with CSA was found. The results parallel those reported for tumour necrosis factor alpha antagonists. Baseline MRI-bone oedema, TSS and anti-CCP predicted radiographic progression.
Original languageEnglish
JournalAnnals of the Rheumatic Diseases
ISSN0003-4967
DOIs
Publication statusPublished - 2010

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