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Kristian Stengaard-Pedersen

Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial

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  • T W Jensen, Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark., Denmark
  • M S Hansen, Denmark
  • Kim Hørslev-Petersen, Center Sønderjylland, Denmark
  • Lars Hyldstrup, LUKKET: 2012 Undervisning, Denmark
  • Bjarke Abrahamsen, LUKKET: 2012 Institut for Lægemiddeldesign og Farm, Denmark
  • Bente Lomholt Langdahl
  • Bo Zerahn, Institut for Klinisk Medicin, Denmark
  • Jan Pødenphant, Institut for Klinisk Medicin, Denmark
  • Kristian Stengaard-Pedersen
  • P Junker
  • ,
  • M Ostergaard, Denmark
  • Tine Lottenburger, Reumatologi, Denmark
  • T Ellingsen, Denmark
  • L S Andersen, Denmark
  • Ib Tønder Hansen
  • Henrik Skjødt, Ortopædi og Intern Medicin, Denmark
  • J K Pedersen, Denmark
  • U B Lauridsen
  • ,
  • A J Svendsen, Denmark
  • U Tarp, Denmark
  • H Lindegaard, Denmark
  • Anne Grethe Jurik
  • Aage Vestergaard, Institut for Klinisk Medicin, Denmark
  • Merete Lund Hetland, Ortopædi og Intern Medicin, Denmark
  • the Cimestra study group
OBJECTIVES: The aims of this study were to investigate the influence of alendronate and intra-articular betamethasone treatment on bone mineral density (BMD) changes in hand, lumbar spine and femoral neck during 1 year of a treat-to-target study (Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA)). PATIENTS AND METHODS: A hundred and sixty patients with early, active rheumatoid arthritis (RA) received methotrexate, intra-articular betamethasone and ciclosporin /placebo-ciclosporin. Patients with Z-score ≤0 also started alendronate 10 mg/day. BMD of the hand (digital x-ray radiogrammetry (DXR-BMDhand)), BMD of lumbar spine and femoral neck (dual x-ray absorptiometry (DXA-BMDlumbar spine and DXA-BMDfemoral neck)) and x-rays of hands, wrists and forefeet (modified Sharp-van der Heijde score) were measured at baseline and 1 year, with complete data available in 107 patients. RESULTS: The change in BMD in hand, lumbar spine and femoral neck was negatively associated with the dose of intra-articular betamethasone (p
Original languageEnglish
JournalAnnals of the Rheumatic Diseases
Volume73
Issue6
Pages (from-to)1123-1129
Number of pages7
ISSN0003-4967
DOIs
Publication statusPublished - 2014

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