Kristian Stengaard-Pedersen

Mannose-binding lectin gene polymorphisms are associated with disease activity and physical disability in untreated, anti-cyclic citrullinated peptide-positive patients with early rheumatoid arthritis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Søren Jacobsen, Denmark
  • Peter Garred, Denmark
  • Hans Ole Madsen, Denmark
  • Niels H H Heegaard, Denmark
  • Merete Lund Hetland, Denmark
  • Kristian Stengaard-Pedersen
  • Peter Junker, Denmark
  • Tine Lottenburger, Denmark
  • Torkel Ellingsen, Denmark
  • Lis Smedegaard Andersen, Denmark
  • Ib Hansen
  • Henrik Skjødt, Denmark
  • Jens Kristian Pedersen, Denmark
  • Ulrik Birk Lauridsen, Denmark
  • Anders J Svendsen, Denmark
  • Ulrik Tarp, Denmark
  • Jan Pødenphant, Denmark
  • Hanne Lindegaard, Denmark
  • Aage Vestergaard, Denmark
  • Mikkel Østergaard, Denmark
  • Kim Hørslev-Petersen, Denmark
  • The Section for Rheumatology
OBJECTIVE: To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA). METHODS: Patients with early RA (n=158) not previously treated with disease modifying antirheumatic drugs, participating in a treatment trial (CIMESTRA study) were examined at inclusion for MBL2 pooled structural genotypes (O/O, A/O, A/A), regulatory MBL2 promoter polymorphism in position -221 (XX, XY, YY), anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2), disease activity by Disease Activity Score-28 (DAS28 score), physical disability by Health Assessment Questionnaire (HAQ) score, and erosive changes in hands and feet (Sharp-van der Heijde score). RESULTS: Eight patients were homozygous MBL2 defective (O/O), 101 belonged to an intermediate group, and 49 were MBL2 high producers (YA/YA). Anti-CCP was present in 93 patients (59%). High scores of disease activity, C-reactive protein-based DAS28 (p=0.02), and physical disability by HAQ (p=0.01) were associated with high MBL2 expression genotypes in a gene-dose dependent way, but only in anti-CCP-positive patients. At this early stage of the disease there was no association with erosion score from radiographs. CONCLUSION: The results point to a synovitis-enhancing effect of MBL in anti-CCP-positive RA, whereas such an effect was not demonstrated for joint erosions.
Original languageEnglish
JournalJournal of Rheumatology
Volume36
Issue4
Pages (from-to)731-5
Number of pages4
ISSN0315-162X
DOIs
Publication statusPublished - 2009

    Research areas

  • Adult, Aged, Arthritis, Rheumatoid, Autoantibodies, Disability Evaluation, Double-Blind Method, Female, Humans, Mannose-Binding Lectin, Middle Aged, Peptides, Cyclic, Polymorphism, Genetic, Promoter Regions, Genetic, Questionnaires, Severity of Illness Index, Young Adult

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