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Kristian Stengaard-Pedersen

Helicobacter pylori infection is not associated with rheumatoid arthritis

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Helicobacter pylori infection is not associated with rheumatoid arthritis. / Bartels, L.; Pedersen, A. B.; Kristensen, N. R.; Jepsen, P.; Vilstrup, H.; Stengaard-Pedersen, K.; Dahlerup, J.

In: Scandinavian Journal of Rheumatology, Vol. 48, No. 1, 01.2019, p. 24-31.

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@article{1398fe9486e14ab48bc7a296df2df28d,
title = "Helicobacter pylori infection is not associated with rheumatoid arthritis",
abstract = "Objective: Rheumatoid arthritis (RA) is an autoinflammatory disease caused by genetic susceptibility and environmental triggers, which include infectious agents. Helicobacter pylori, a bacterium that frequently colonizes the stomach, is associated with the development of certain autoinflammatory disorders. This study examined a possible association between H. pylori infection and RA. Method: This cohort study was performed in the Central Denmark Region. Patients were enrolled from primary healthcare centres after a urea breath test (UBT) for H. pylori and followed for a median of 8 years. Nationwide administrative registries provided information about the patients’ diagnoses, country of birth, and gender. Comorbidity was determined using the Charlson Comorbidity Index. We compared the prevalence of RA via odds ratios (ORs) and incidences using Cox regression to calculate the hazard ratios (HRs) by comparing H. pylori-positive and H. pylori-negative individuals and adjusting for confounding variables. Results: A total of 56 000 people diagnosed as H. pylori positive or negative had similar rates of comorbidity. No link was found between H. pylori and RA. There was no difference in RA prevalence until time of UBT [OR = 0.91, 95{\%} confidence interval (CI) 0.70–1.19)] or incidence of new RA cases after UBT (HR = 0.80, 95{\%} CI 0.56–1.13) between H. pylori-positive and -negative subjects. Validation via four other RA definitions provided similar results. Conclusion: This study found no association between H. pylori infection and RA. This result does not support the involvement of H. pylori in a gut–joint axis of importance for RA development.",
keywords = "CLINICAL REGISTER, DIAGNOSES, EPIDEMIOLOGY, ERADICATION, MICROBIOME, PATHOGENESIS, PORPHYROMONAS-GINGIVALIS, PREVALENCE, SEVERITY, TO-TARGET STRATEGY",
author = "L. Bartels and Pedersen, {A. B.} and Kristensen, {N. R.} and P. Jepsen and H. Vilstrup and K. Stengaard-Pedersen and J. Dahlerup",
year = "2019",
month = "1",
doi = "10.1080/03009742.2018.1464205",
language = "English",
volume = "48",
pages = "24--31",
journal = "Scandinavian Journal of Rheumatology",
issn = "0300-9742",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Helicobacter pylori infection is not associated with rheumatoid arthritis

AU - Bartels, L.

AU - Pedersen, A. B.

AU - Kristensen, N. R.

AU - Jepsen, P.

AU - Vilstrup, H.

AU - Stengaard-Pedersen, K.

AU - Dahlerup, J.

PY - 2019/1

Y1 - 2019/1

N2 - Objective: Rheumatoid arthritis (RA) is an autoinflammatory disease caused by genetic susceptibility and environmental triggers, which include infectious agents. Helicobacter pylori, a bacterium that frequently colonizes the stomach, is associated with the development of certain autoinflammatory disorders. This study examined a possible association between H. pylori infection and RA. Method: This cohort study was performed in the Central Denmark Region. Patients were enrolled from primary healthcare centres after a urea breath test (UBT) for H. pylori and followed for a median of 8 years. Nationwide administrative registries provided information about the patients’ diagnoses, country of birth, and gender. Comorbidity was determined using the Charlson Comorbidity Index. We compared the prevalence of RA via odds ratios (ORs) and incidences using Cox regression to calculate the hazard ratios (HRs) by comparing H. pylori-positive and H. pylori-negative individuals and adjusting for confounding variables. Results: A total of 56 000 people diagnosed as H. pylori positive or negative had similar rates of comorbidity. No link was found between H. pylori and RA. There was no difference in RA prevalence until time of UBT [OR = 0.91, 95% confidence interval (CI) 0.70–1.19)] or incidence of new RA cases after UBT (HR = 0.80, 95% CI 0.56–1.13) between H. pylori-positive and -negative subjects. Validation via four other RA definitions provided similar results. Conclusion: This study found no association between H. pylori infection and RA. This result does not support the involvement of H. pylori in a gut–joint axis of importance for RA development.

AB - Objective: Rheumatoid arthritis (RA) is an autoinflammatory disease caused by genetic susceptibility and environmental triggers, which include infectious agents. Helicobacter pylori, a bacterium that frequently colonizes the stomach, is associated with the development of certain autoinflammatory disorders. This study examined a possible association between H. pylori infection and RA. Method: This cohort study was performed in the Central Denmark Region. Patients were enrolled from primary healthcare centres after a urea breath test (UBT) for H. pylori and followed for a median of 8 years. Nationwide administrative registries provided information about the patients’ diagnoses, country of birth, and gender. Comorbidity was determined using the Charlson Comorbidity Index. We compared the prevalence of RA via odds ratios (ORs) and incidences using Cox regression to calculate the hazard ratios (HRs) by comparing H. pylori-positive and H. pylori-negative individuals and adjusting for confounding variables. Results: A total of 56 000 people diagnosed as H. pylori positive or negative had similar rates of comorbidity. No link was found between H. pylori and RA. There was no difference in RA prevalence until time of UBT [OR = 0.91, 95% confidence interval (CI) 0.70–1.19)] or incidence of new RA cases after UBT (HR = 0.80, 95% CI 0.56–1.13) between H. pylori-positive and -negative subjects. Validation via four other RA definitions provided similar results. Conclusion: This study found no association between H. pylori infection and RA. This result does not support the involvement of H. pylori in a gut–joint axis of importance for RA development.

KW - CLINICAL REGISTER

KW - DIAGNOSES

KW - EPIDEMIOLOGY

KW - ERADICATION

KW - MICROBIOME

KW - PATHOGENESIS

KW - PORPHYROMONAS-GINGIVALIS

KW - PREVALENCE

KW - SEVERITY

KW - TO-TARGET STRATEGY

UR - http://www.scopus.com/inward/record.url?scp=85049986148&partnerID=8YFLogxK

U2 - 10.1080/03009742.2018.1464205

DO - 10.1080/03009742.2018.1464205

M3 - Journal article

C2 - 30014755

AN - SCOPUS:85049986148

VL - 48

SP - 24

EP - 31

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 1

ER -