Kristian Stengaard-Pedersen

Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity

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DOI

  • S. F. Issa, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol
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  • A. F. Christensen, Vejle Hosp, Dept Rheumatol
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  • H. M. Lindegaard, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol
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  • M. L. Hetland, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci
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  • K. Horslev-Petersen, King Christian X Hosp Rheumat Dis, Res Unit
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  • K. Stengaard-Pedersen
  • B. J. Ejbjerg, Slagelse Hosp, Dept Rheumatol
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  • T. Lottenburger, Vejle Hosp, Dept Rheumatol
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  • T. Ellingsen, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol
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  • J. K. Pedersen, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol
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  • K. Junker, Univ Southern Denmark, University of Southern Denmark, Inst Mol Med Canc & Inflammat
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  • A. Svendsen, Danish Twin Registry, Inst Publ Hlth, Epidemiol
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  • U. Tarp
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  • M. Ostergaard, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis, Rigshosp, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci
  • ,
  • P. Junker, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol

Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin-3 in patients with newly diagnosed RA and associations with disease profile, Magnetic resonance imaging (MRI) findings and seromarkers of synovial matrix inflammation. One hundred and sixty DMARD naive patients newly diagnosed with RA were included (CIMESTRA study). Clinical, serological and imaging data were recorded before treatment and at 6weeks, 3 and 12months. Galectin-3 and hyaluronan (HYA) were measured by ELISA (R&D and Corgenix, USA), and the N-terminal propeptide of type III collagen (PIIINP) by radioimmunoassay (Orion Diagnostica, Finland). One hundred and nineteen, 87 and 60 blood donors served as controls for galectin-3, HYA and PIIINP, respectively. Baseline galectin-3 was significantly elevated in anti-CCP positive (4.2g/l IQR [3.6;6.1]) patients as compared with anti-CCP negatives (4.0g/l [2.6;4.9], P=0.05) and controls (3.8g/l [3.0;4.8], P

Original languageEnglish
JournalScandinavian Journal of Immunology
Volume86
Issue6
Pages (from-to)471-478
Number of pages8
ISSN0300-9475
DOIs
Publication statusPublished - Dec 2017

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