Kousik Sarathy Sridharan

Corticomuscular coherence during hand gripping with DBS and medication in PD patients

Research output: Contribution to conferencePosterResearch

Deep brain stimulation (DBS) effectively alleviates the motor symptoms in Parkinson’s disease (PD) although its effect mechanism is still unclear. CMC is reduced in PD patients but restorable with medication, while DBS variably affects CMC in advanced PD patients.

We recorded magnetoencephalography (MEG) from six PD patients performing hand gripping during DBS ON and medicated (levodopa, MED ON) conditions and from ten age-matched healthy controls. Participants performed isotonic contractions (hand gripping) with their right hand, and electromyography (EMG) was recorded from the extensor digitorum communis muscle with a belly-tendon montage. We calculated the mean-squared coherence between MEG and the rectified EMG signals. For each group and condition, we selected the maximum CMC value in the beta range (13-30 Hz) within the average of an a priori selection of nine left sensorimotor gradiometer pairs in the grand averaged data for each group and condition.

Medication (MED ON) seemed to increase CMC values in PD patients to even higher levels than the controls, whereas DBS led to reduced CMC values. Both treatments had similar effects on the patients’ motor symptoms (UPDRS-III). Hence, although both medication and DBS ameliorate clinical motor performance to similar extents, they seem to have differentiated effects on CMC.
Original languageEnglish
Publication year2016
Publication statusPublished - 2016
EventNeuroscience day 2016 -
Duration: 4 May 2016 → …

Conference

ConferenceNeuroscience day 2016
Period04/05/2016 → …

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