Konstantin Kazankov

Effects of lifestyle intervention on soluble CD163, a macrophage activation marker, in patients with non-alcoholic fatty liver disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Sidsel Rødgaard-Hansen
  • ,
  • Alexis St George, b Storr Liver Centre, Westmead Institute for Medical Research , University of Sydney and Westmead Hospital , Australia.
  • ,
  • Konstantin Kazankov
  • Adrian Bauman, d Centre for Physical Activity and Health, School of Public Health , Sydney University , Australia.
  • ,
  • Jacob George, b Storr Liver Centre, Westmead Institute for Medical Research , University of Sydney and Westmead Hospital , Australia.
  • ,
  • Henning Grønbæk
  • Holger Jon Møller

OBJECTIVE: Liver macrophages play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Soluble CD163 (sCD163), a macrophage-specific biomarker, reflects disease activity in the range of liver diseases. The impact of lifestyle intervention on sCD163 in adult NAFLD patients has not been investigated.

MATERIAL AND METHODS: We assessed 126 NAFLD patients participating in a lifestyle intervention study for sCD163 concentrations at baseline, after the three-month intervention period, and at long-term follow-up after 12 and 24 months.

RESULTS: The median sCD163 concentration at baseline was 2.59 mg/L (IQR = 1.78-3.63 mg/L). There was a significant decrease in sCD163 from baseline to three months follow-up (-0.64 mg/L, p < .001) with no difference between the four study groups (p = .6). At 12 and 24 months follow-up, the sCD163 concentrations had returned to baseline level (p = .3 and p = .1). Baseline sCD163 correlated with liver biomarkers and metabolic variables. There was a significantly greater decrease in sCD163 in patients who had a decrease in alanine aminotransferase (ALT) compared with patients with unchanged or increased ALT (-0.76 mg/L vs. -0.41 mg/L, p = .02), and in patients with a decrease in HOMA-IR compared with individuals with no decrease (-0.86 mg/L vs. -0.55 mg/L, p = .03).

CONCLUSION: sCD163 is associated with markers of liver necro-inflammation and glucose homoeostasis in NAFLD. Participation in a lifestyle intervention programme resulted in a significant reduction in sCD163. Our data support the utility of sCD163 as a biomarker for monitoring the efficacy of therapeutic interventions in NAFLD.

Original languageEnglish
JournalScandinavian journal of clinical and laboratory investigation
Volume77
Issue7
Pages (from-to)498-504
Number of pages7
ISSN0036-5513
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • Journal Article

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