Kim Frisch

2025

Reactivity-based metabolomics reveal cysteine has glyoxalase 1-like and glyoxalase 2-like activities

Daniel Opfermann, M., Bøgelund Søndergård, M., Vase Bech, L., Nielsen, C. B., Mahía, A., Brinck Holt, C., Wang, T., Bisgaard Olesen, S., Frisch, K., Appel Østergaard, J., Britz, D., Lykke Nielsen, K., Galligan, J. J., Poulsen, T. B., Hansen, J. & Johannsen, M., 2025, (E-pub / Early view) In: Nature Chemical Biology. 2004.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2024

Desorption Electrospray Ionization Mass Spectrometry Imaging of Powder-Treated Fingermarks on Forensic Gelatin Lifters and its Application for Separating Overlapping Fingermarks

Frisch, K., Nielsen, K. L., Hasselstro̷m, J. B., Fink, R., Rasmussen, S. V. & Johannsen, M., Jul 2024, In: Analytical Chemistry. 96, 30, p. 12497-12507 11 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

Ny metode til analyse af fingeraftryk har store perspektiver

Frisch, K., 11 Sept 2024, In: Dansk Politi. 4, p. 32-33

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication

2023

MALDI MSI Separation of Same Donor’s Fingermarks Based on Time of Deposition—A Proof-of-Concept Study

Frisch, K., Nielsen, K. L. & Francese, S., Mar 2023, In: Molecules. 28, 6, 13 p., 2763.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

7 Citations (Scopus)

2022

A Retrospective Metabolomics Analysis of Gamma-Hydroxybutyrate in Humans: New Potential Markers and Changes in Metabolism Related to GHB Consumption

Wang, T., Nielsen, K. L., Frisch, K., Lassen, J. K., Nielsen, C. B., Andersen, C. U., Villesen, P., Andreasen, M. F., Hasselstrøm, J. B. & Johannsen, M., Mar 2022, In: Frontiers in Pharmacology. 13, 816376.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

5 Citations (Scopus)

N-(4-[¹⁸F]fluorobenzyl)cholylglycine, a potential tracer for positron emission tomography of enterohepatic circulation and drug-induced inhibition of ileal bile acid transport: A proof-of-concept PET/CT study in pigs

Frisch, K., Mortensen, F. V., Munk, O. L., Gormsen, L. C. & Alstrup, A. K. O., Nov 2022, In: Nuclear Medicine and Biology. 114-115, p. 49-57 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

2 Citations (Scopus)

31 Downloads (Pure)

The pathophysiology of Wilson’s disease visualized: A human ⁶⁴Cu PET study

Sandahl, T. D., Gormsen, L. C., Kjærgaard, K., Vendelbo, M., Munk, D. E., Munk, O. L., Bender, D., Keiding, S., Vase, K. H., Frisch, K., Vilstrup, H. V. A. & Ott, P., Jun 2022, In: Hepatology. 75, 6, p. 1461-1470 10 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

22 Citations (Scopus)

43 Downloads (Pure)

2021

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

Kjærgaard, K., Frisch, K., Sørensen, M., Munk, O. L., Hofmann, A. F., Horsager, J., Schacht, A. C., Erickson, M., Shapiro, D. A. & Keiding, S., Jan 2021, In: Journal of Hepatology. 74, 1, p. 58-65 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

File

66 Citations (Scopus)

102 Downloads (Pure)

Reply to: "Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion"

Keiding, S., Frisch, K. & Hofmann, A. F., May 2021, In: Journal of Hepatology. 74, 5, p. 1268-1269 2 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research

2020

Intravenous and oral copper kinetics, biodistribution and dosimetry in healthy humans studied by [⁶⁴Cu]copper PET/CT

Kjærgaard, K., Sandahl, T. D., Frisch, K., Vase, K. H., Keiding, S., Vilstrup, H., Ott, P., Gormsen, L. C. & Munk, O. L., Jun 2020, In: EJNMMI Radiopharmacy and Chemistry. 5, 1, 12 p., 15.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

26 Citations (Scopus)

The role of dopaminergic and serotonergic transmission in the processing of primary and monetary reward

Schmidt, C., Skandali, N., Gleesborg, C., Kvamme, T. L., Schmidt, H., Frisch, K., Møller, A. & Voon, V., Aug 2020, In: Neuropsychopharmacology. 45, 9, p. 1490-1497 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

10 Citations (Scopus)

Use of Indocyanine Green (ICG) in Hepatology

Frisch, K. & Keiding, S., 2020, In: Advanced Research in Gastroenterology & Hepatology. 16, 2, 4 p., 555932.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2019

Biodistribution and radiation dosimetry of 64CuCl2 PET/CT by intravenous and oral administration in healthy humans

Kjærgaard, K., Sandahl, T. D., Frisch, K., Keiding, S., Vilstrup, H. V. A., Ott, P., Gormsen, L. C. & Munk, O. L., 10 May 2019.

Research output: Contribution to conference › Poster › Research › peer-review

Human biodistribution, dosimetry, radiosynthesis and quality control of the bile acid PET tracer [N-methyl-11C]cholylsarcosine

Frisch, K., Kjærgaard, K., Horsager, J., Schacht, A. C. & Munk, O. L., Jun 2019, In: Nuclear Medicine and Biology. 72-73, May-June, p. 55-61 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

7 Citations (Scopus)

Obeticholic acid improves hepatobiliary excretion of bile acids in patients with PBC

Kjærgaard, K., Frisch, K., Munk, O. L., Hofmann, A. F., Sørensen, M., Horsager, J., Erickson, M., Shapiro, D. A. & Keiding, S., 9 Nov 2019.

Research output: Contribution to conference › Poster › Research › peer-review

Radiolabeling of protected tryptophan with [¹⁸F]fluoromethyl tosylate: Formation of [¹⁸F]fluoromethyl ester of tryptophan instead of 1-N-[¹⁸F]fluoromethyl tryptophan methylester.

Venkatachalam, T. K., Stimson, D. H. R., Frisch, K., Pierens, G. K., Bhalla, R. & Reutens, D. C., Oct 2019, In: Applied Radiation and Isotopes. 152, October, p. 172-179 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2018

Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Ørntoft, N., Frisch, K., Ott, P., Keiding, S. & Sørensen, M., Apr 2018, In: B B A - Molecular Basis of Disease. 1864, 4, Part B, p. 1240-1244 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

9 Citations (Scopus)

Galdesalte på godt og ondt

Frisch, K. & Alstrup, A. K. O., Aug 2018, In: Dyrlægen. 4, p. 42-46

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication

N-(4-[¹⁸F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats

Frisch, K., H.R. Stimson, D., Venkatachalam, T., K. Pierens, G., Keiding, S., Reutens, D. & Bhalla, R., Jun 2018, In: Nuclear Medicine and Biology. 61, p. 56-62 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

6 Citations (Scopus)

N-(4-[¹⁸F]fluorobenzyl)cholylglycine, a novel tracer for positron emission tomography of enterohepatic circulation of bile acids: proof-of-concept study in rats

Frisch, K., H.R. Stimson, D., Venkatachalam, T., K. Pierens, G., Keiding, S., Reutens, D. & Bhalla, R., 2018.

Research output: Contribution to conference › Poster › Research › peer-review

On the evolution of bile salts and the farnesoid X receptor in vertebrates

Frisch, K. & Alstrup, A. K. O., 1 Mar 2018, In: Physiological and Biochemical Zoology. 91, 2, p. 797-813 17 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

10 Citations (Scopus)

Quantitative PET of liver functions

Keiding, S., Sørensen, M., Frisch, K., Gormsen, L. C. & Munk, O. L., 2018, In: American Journal of Nuclear Medicine and Molecular Imaging. 8, 2, p. 73-85 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

Strålende Galdesyrer

Frisch, K., 2018, In: Aktuel Naturvidenskab. 5, p. 24–28

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication

2017

Hepatobiliary transport kinetics of the conjugated bile acid tracer 11C-CSar quantified in healthy humans and patients by positron emission tomography

Ørntoft, N. W., Munk, O. L., Frisch, K., Ott, P., Keiding, S. & Sørensen, M., Aug 2017, In: Journal of Hepatology. 67, 2, p. 321-327 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

41 Citations (Scopus)

Positron Emission Tomography of the Enterohepatic Circulation of Conjugated Bile Acids in Rats

Frisch, K., H.R. Stimson, D., Venkatachalam, T., K. Pierens, G., Keiding, S., Reutens, D. & Bhalla, R., 2017.

Research output: Contribution to conference › Poster › Research › peer-review

2016

Hepatobiliary Secretion Kinetics of Conjugated Bile Acids Measured in Pigs by 11C-Cholylsarcosine PET

Sørensen, M., Munk, O. L., Oerntoft, N., Frisch, K., Andersen, K. J., Mortensen, F. V., Alstrup, A. K. O., Ott, P., Hofmann, A. F. & Keiding, S., 1 Jun 2016, In: The Journal of Nuclear Medicine. 57, 6, p. 961-966 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

24 Citations (Scopus)

Radiosynthesis of N-¹¹C-Methyl-Taurine-Conjugated Bile Acids and Biodistribution Studies in Pigs by PET/CT

Schacht, A. C., Sørensen, M., Munk, O. L. & Frisch, K., 1 Apr 2016, In: Journal of Nuclear Medicine. 57, 4, p. 628-33 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

16 Citations (Scopus)

2014

Development of carbon-11 labelled N-methyl-taurine conjugated bile acids as PET-tracers for measuring hepatic secretion of bile acids

Schacht, A. C., Sørensen, M., Munk, O. L. & Frisch, K., 8 Oct 2014.

Research output: Contribution to conference › Poster › Research › peer-review

On fluoro-18 labeling of bile acids

Frisch, K. & Sørensen, M., 2014, In: Nuclear Medicine and Biology. 41, 9, p. 775

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research

2 Citations (Scopus)

The lumped constant for the galactose analog 2-18F-fluoro-2-deoxy-D-galactose is increased in patients with parenchymal liver disease

Mikkelsen, K. S., Sørensen, M., Frisch, K., Villadsen, G. E., Bibby, B. M. & Keiding, S., Apr 2014, In: Journal of Nuclear Medicine. 55, 4, p. 590-4 5 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

3 Citations (Scopus)

2013

Positron emission tomography of hepatobiliary transport: development of 11C-cholylsarcosine, a PET-tracer for conjugated bile acids

Frisch, K., Sørensen, M., Hofmann, A. & Keiding, S., 2013, XXII International Bile Acid Meeting - Hepatic and Extrahepatic Targets of Bile Acid Signaling. Falk Symposium 184, Vienna, 2012. Karger Medical and Scientific Publishers, p. 96-103

Research output: Contribution to book/anthology/report/proceeding › Article in proceedings › Research › peer-review

Regional metabolic liver function measured by 2-[18F]fluoro-2-deoxy-D-galactose PET/CT in patients with cirrhosis

Sørensen, M., Sandager Mikkelsen, K., Frisch, K., Villadsen, G. E. & Keiding, S., 2013, In: Journal of Hepatology. 58, p. 1119−1124

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Regional metabolic liver function measured in patients with cirrhosis by 2-[¹⁸F]fluoro-2-deoxy-D-galactose PET/CT

Sørensen, M., Mikkelsen, K. S., Frisch, K., Villadsen, G. E. & Keiding, S., Jun 2013, In: Journal of Hepatology. 58, 6, p. 1119-24 6 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

27 Citations (Scopus)

2012

[N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: Radiosynthesis and proof-of-concept studies in pigs

Frisch, K., Jakobsen, S., Sørensen, M., Munk, O. L., Alstrup, A. K. O., Ott, P., Hofmann, A. F. & Keiding, S., 2012, In: Journal of Nuclear Medicine. 53, 5, p. 772-8 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

32 Citations (Scopus)

Biliary secretion

Frisch, K. & Hofmann, A. F., 2012, Functional Molecular Imaging in Hepatology. p. 49-75

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

Carbon-11 labelled cholylsarcosine: a PET-tracer for conjugated bile acids

Frisch, K., Jakobsen, S., Sørensen, M., Munk, O. L., Alstrup, A. K. O., Ott, P., Hofmann, A. F. & Keiding, S., 2012.

Research output: Contribution to conference › Poster › Research › peer-review

Carbon-11 labelling of cholylsarcosine and in vivo imaging of conjugated bile acids by positron emission tomography

Frisch, K., Jakobsen, S., Sørensen, M., Munk, O. L., Alstrup, A. K. O., Ott, P., Hofmann, A. F. & Keiding, S., 2012.

Research output: Contribution to conference › Poster › Research › peer-review

Uptake of Conjugated Bile Acids from Blood to Hepatocytes and Subsequent Excretion into Bile Canaliculi Measured by [N-methyl-11C]Cholylsarcosine PET/CT in Pigs

Sørensen, M., Frisch, K., Mortensen, F. V., Alstrup, A. K. O. & Keiding, S., 9 Nov 2012.

Research output: Contribution to conference › Poster › Research › peer-review

2011

Hepatic galactose metabolism quantified in humans using 2-18F-fluoro-2-deoxy-D-galactose PET/CT

Sørensen, M., Mikkelsen, K. S., Frisch, K., Bass, L., Bibby, B. M. & Keiding, S., 29 Aug 2011, In: Journal of Nuclear Medicine. 52, 10, p. 1566-1572 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

34 Citations (Scopus)

Nucleophilic radiosynthesis of 2-[18F]fluoro-2-deoxy-D-galactose from Talose triflate and biodistribution in a porcine model

Frisch, K., Bender, D., Hansen, S. B., Keiding, S. & Sørensen, M., May 2011, In: Nuclear Medicine and Biology. 38, 4, p. 477-483 7 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

23 Citations (Scopus)

The potential use of 2-[¹⁸F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma

Sørensen, M., Frisch, K., Bender, D. & Keiding, S., Sept 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 9, p. 1723-1731 9 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

35 Citations (Scopus)

2010

Bile acid metabolism

Frisch, K., 2010, In: Scandinavian Journal of Gastroenterology. Supplement. 45, p. 42 1 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review

2008

Organocatalytic Asymmetric Vinylogous Addition to Quinones - Formation of Optically Active α-Aryl Ketones

Aleman, J., Jacobsen, C. B., Frisch, K., Overgaard, J. & Jørgensen, K. A., 2008, In: Chemical Communications. p. 632

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

12 Citations (Scopus)

2007

Organocatalytic Asymmetric Destruction of 1-Benzylated Reissert Compounds Catalyzed by Quaternary Cinchona Alkaloids

Frisch, K. & Jørgensen, K. A., 2007, In: Organic & Biomolecular Chemistry. 5, p. 2966

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

20 Citations (Scopus)

2006

Asymmetric Annulation Reactions of Isoquinolinium Derivatives Catalyzed by Chiral Secondary Amines

Frisch, K., Landa, A., Saaby, S. & Jørgensen, K. A., 5 Jul 2006.

Research output: Contribution to conference › Poster › Research › peer-review

Development of Novel Organocatalytic Asymmetric Reactions: Addition of Nucleophiles to Activated Isoquinolines - Kinetic Resolution of Benzylated Reissert Compounds - Addition of Electrophiles to Activated Alkylidenes

Frisch, K., 2006

Research output: Types of Thesis › PhD thesis

Organocatalytic Asymmetric Deconjugative Michael Additions

Bell, M., Frisch, K. & Jørgensen, K. A., 2006, In: J. Org. Chem.. 71, p. 5407

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

52 Citations (Scopus)

2005

Organocatalytic Diastereo- and Enantioselective Annulation Reactions - Construction of Optically Active 1,2-Dihydro-Isoquinoline and Phthalazine Derivatives

Frisch, K., Landa, A., Saaby, S. & Jørgensen, K. A., 2005, In: Angewandte Chemie. International edition. English. 44, p. 6058

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2000

Reduction of p-Benzoquinone Induced by Hydroxide Ions

Frisch, K., Larsen, J. B. & Daasbjerg, K., 6 Nov 2000.

Research output: Contribution to conference › Poster › Research

Kim Frisch

Research output

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