Ken Howard

  1. 2020
  2. Published

    FcRn overexpression in human cancer drives albumin recycling and cell growth : a mechanistic basis for exploitation in targeted albumin-drug designs. / Larsen, Maja Thim; Mandrup, Ole A; Schelde, Karen Kræmmer; Luo, Yonglun; Sørensen, Karina Dalsgaard; Dagnæs-Hansen, Frederik; Cameron, Jason; Stougaard, Magnus; Steiniche, Torben; Howard, Kenneth A.

    In: Journal of Controlled Release, Vol. 322, 06.2020, p. 53-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. / Kania, Karolina ; Colella, Fabio; Riemen, Anna H.K. ; Wang, Hui ; Howard, Ken; Aigner, Thomas; Dell’Accio, Francesco ; Capellini, Terence D. ; Roelofs, Anke J. ; De Bari, Cosimo .

    In: Scientific Reports, Vol. 10, No. 1, 157, 13.01.2020, p. 157.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. / Juul-Madsen, Kristian; Qvist, Per; Bendtsen, Kirstine L; Langkilde, Annette E; Vestergaard, Bente; Howard, Ken; Dehesa-Etxebeste, Martxel; Paludan, Søren R; Andersen, Gregers Rom; Jensen, Poul Henning; Otzen, Daniel E; Romero-Ramos, Marina; Vorup-Jensen, Thomas.

    In: Journal of Immunology, Vol. 204, No. 5, 2020, p. 1345-1361.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. 2019
  6. Published

    Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model (uCaP) for Prostate Cancer in Cell-Free Urine. / Fredsøe, Jacob; Rasmussen, Anne K I; Laursen, Emma B; Cai, Yunpeng; Howard, Kenneth A; Pedersen, Bodil G; Borre, Michael; Mouritzen, Peter; Òrntoft, Torben; Sørensen, Karina D.

    In: Clinical Chemistry, Vol. 65, No. 4, 04.2019, p. 540-548.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling. / Nandakumar, Ramya; Tschismarov, Roland; Meissner, Felix; Prabakaran, Thaneas; Krissanaprasit, Abhichart; Farahani, Ensieh; Zhang, Bao cun; Assil, Sonia; Martin, Amandine; Bertrams, Wilhelm; Holm, Christian K.; Ablasser, Andrea; Klause, Tanja; Thomsen, Martin K.; Schmeck, Bernd; Howard, Kenneth A.; Henry, Thomas; Gothelf, Kurt V.; Decker, Thomas; Paludan, Søren R.

    In: Nature Microbiology, Vol. 4, 04.2019, p. 701-713.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis. / Garcia, JP; Stein, J; Cai, Yunpeng; Riemers, F; Wexselblatt, E; Wengel, Jesper; Tryfonidou, M; Yayon, A; Howard, Ken; Creemers, Laura B.

    In: Journal of Controlled Release, Vol. 294, 01.2019, p. 247-258.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    A new class of recombinant human albumin with multiple surface thiols exhibit stable conjugation, and enhanced FcRn binding and blood circulation. / Schelde, Karen Kræmmer; Nicholls , Karl ; Dagnæs-Hansen, Frederik; Bunting , Karen ; Rawsthorne, Helen ; Andersen, Birgitte; Finnis, Christopher; Williamson, Miranda ; Cameron, Jason; Howard, Ken.

    In: Journal of Biological Chemistry, Vol. 294, No. 10, 2019, p. 3735-3743.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Accepted/In press

    Albumin-binding fatty acid-modified gapmer antisense oligonucleotides for modulation of pharmacokinetics. / Cai, Yunpeng; Lou, Chenguang; Wengel, Jesper; Howard, Ken.

    In: Methods in Molecular Biology, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Accepted/In press

    Biomolecular Assemblies as Multifunctional Drug Designs. / Howard, Ken.

    Second Edition ed. Pan Stanford Publishing, 2019. (Handbook of Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications. ).

    Research output: Book/anthology/dissertation/reportBookResearchpeer-review

  12. Published

    Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers. / Hall, Archie; Nicholls , Karl ; Caspersen , Mikael B. ; Skrivergaard, Stig; Howard, Ken; Karu, Kersti; Chudasama, Vijay; Baker, James R.

    In: Organic & Biomolecular Chemistry, Vol. 17, No. 34, 2019, p. 7870-7873.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. 2018
  14. Published

    Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement. / Larsen, Maja Thim; Rawsthorne, Helen ; Schelde, Karen Kræmmer; Dagnæs-Hansen, Frederik; Cameron, Jason; Howard, Ken.

    In: Journal of Controlled Release, Vol. 287, 10.10.2018, p. 132-141.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Targeting Biological Barriers. / Moein Moghimi, Seyed; Howard, Ken.

    In: Molecular Therapy, Vol. 26, No. 4, 04.04.2018, p. 933-934.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity. / Cai, Yunpeng; Makarova, Anna-Marie; Wengel, Jesper; Howard, Ken.

    In: Journal of Gene Medicine, Vol. 20, No. 7-8, e3025, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. 2017
  18. Published

    An albumin-oligonucleotide assembly for potential combinatorial drug delivery and half-life extension applications. / Kuhlmann, Matthias; Hamming, Jonas Bohn Refslund; Voldum, Anders ; Tsakiridou, Georgia; Larsen, Maja Thim; Schmøkel, Julie; Sohn, Emil ; Bienk, Konrad; Schaffert, David Henning; Sørensen, Esben Skipper; Wengel, Jesper; Dupont, Daniel Miotto; Howard, Ken.

    In: Molecular Therapy - Nucleic Acids, Vol. 9, 15.12.2017, p. 284-293.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria. / Christiansen, Stig Hill; Murphy, Ronan A.; Juul-Madsen, Kristian; Fredborg, Marlene; Hvam, Michael Lykke; Axelgaard, Esben; Skovdal, Sandra M.; Meyer, Rikke Louise; Sorensen, Uffe B. Skov; Moeller, Arne; Nyengaard, Jens Randel; Norskov-Lauritsen, Niels; Wang, Mikala; Gadjeva, Mihaela; Howard, Kenneth A.; Davies, Jane C.; Petersen, Eskild; Vorup-Jensen, Thomas.

    In: Scientific Reports, Vol. 7, 15653, 15.11.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin. / Schmidt, Esben G. W.; Hvam, Michael L.; Antunes, Filipa; Cameron, Jason; Viuff, Dorthe; Andersen, Birgitte; Kristensen, Nanna N.; Howard, Kenneth A.

    In: Journal of Biological Chemistry, Vol. 292, No. 32, 11.08.2017, p. 13312-13322.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    Fatty acid-modified gapmer antisense oligonucleotide and human serum albumin constructs for pharmacokinetic modulation. / Hvam, Michael Lykke; Cai, Yunpeng; Dagnæs-Hansen, Frederik; Nielsen, Jesper; Wengel, Jesper; Kjems, Jørgen; Howard, Ken.

    In: Molecular Therapy, Vol. 25, No. 7, 05.07.2017, p. 1710-1717.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Albumin-based drug delivery using cysteine 34 chemical conjugates; important considerations and requirements. / Caspersen , Mikael B. ; Kuhlmann, Matthias; Nicholls , Karl ; Saxton , Malcolm J. ; Andersen , Birgitte ; Bunting , Karen ; Cameron, Jason ; Howard, Ken.

    In: Therapeutic Delivery, Vol. 8, No. 7, 30.05.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography. / Blans, Kristine Ingrid Marie; Hansen, Maria Stenum; Sørensen, Laila V.; Hvam, Michael Lykke; Howard, Ken; Möller, Arne; Wiking, Lars; Larsen, Lotte Bach; Rasmussen, Jan Trige.

    In: Journal of Extracellular Vesicles, Vol. 6, No. 1, 1294340, 15.03.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage. / Christiansen, Stig Hill; Zhang, Xianwei; Juul-Madsen, Kristian; Hvam, Michael Lykke; Vad, Brian Stougaard; Behrens, Manja Annette; Thygesen, Ida Lysgaard; Jalilian, Babak; Pedersen, Jan Skov; Howard, Ken; Otzen, Daniel E; Vorup-Jensen, Thomas.

    In: B B A - Biomembranes, Vol. 1859, No. 3, 03.2017, p. 425-437.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis. / Cai, Yunpeng; López-Ruiz , Elena; Wengel, Jesper; Creemers, Laura; Howard, Ken.

    In: Journal of Controlled Release, Vol. 253, No. May, 2017, p. 153-159.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications. / Hansen, Irene ; Ebbesen, Morten Frendø; Kaspersen, Liselotte ; Thomsen, Troels Bo; Bienk, Konrad; Cai, Yunpeng; Malle, Birgitte M; Howard, Ken.

    In: Molecular Pharmaceutics, Vol. 14, No. 7, 2017, p. 2359–2367.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding. / Schmøkel, Julie; Voldum, Anders ; Tsakiridou, Georgia; Kuhlmann, Matthias; Cameron, Jason; Sørensen, Esben Skipper; Wengel, Jesper; Howard, Ken.

    In: Nanotechnology, Vol. 28, 204004 , 2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. 2016
  29. Published

    Chip-Free Microscale-Incubator-Based Synthesis of Chitosan-Based Gene Silencing Nanoparticles. / Gaglianone, Noemi; Hvam, Michael Lykke; Aslan, Hüsnü; Dong, Mingdong; Howard, Ken; Ho, Yi-Ping.

    In: Particle & Particle Systems Characterization, Vol. 33, No. 5, 05.2016, p. 279-285.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Albumin-based drug delivery : harnessing nature to cure disease. / Larsen, Maja Thim; Kuhlmann, Matthias; Hvam, Michael Lykke; Howard, Ken.

    In: Molecular and Cellular Therapies, Vol. 4, No. 3, 27.02.2016, p. 3.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing. / Bienk, Konrad; Hvam, Michael Lykke; Pakula, Malgorzata Maria; Dagnæs-Hansen, Frederik; Wengel, Jesper; Malle, Birgitte Mølholm; Kragh-Hansen, Ulrich; Cameron, Jason; Bukrinski, Jens Thostrup; Howard, Ken.

    In: Journal of Controlled Release, Vol. 232, 2016, p. 143-151.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Generation of a Double Transgenic Humanised Neonatal Fc Receptor (FcRn)/Albumin Mouse to Study the Pharmacokinetics of Albumin-linked Drugs. / Viuff, Dorthe; Antunes, Filipa ; Evans, Leslie; Cameron, Jason; Dyrnesli, Hans; Ravn, Birgitte Thue; Stougaard, Magnus; Thiam, Kader; Andersen, Birgitte; Kjærulff, Søren; Howard, Ken.

    In: Journal of Controlled Release, Vol. 223, 2016, p. 22-30.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Highly porous PEGylated Bi2S3 nano-urchins as a versatile platform for in vivo triple-modal imaging, photothermal therapy and drug delivery. / Li, Zhenglin; Hu, Ying; Chang, Manli; Howard, Ken; Fan, Xuelei; Sun, Ye; Besenbacher, Flemming; Yu, Miao.

    In: Nanoscale, Vol. 8, No. 35, 2016, p. 16005-16016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. Published

    Human serum albumin coated Prussian blue nanoparticles as pH-/thermo-triggered drug delivery vehicles for cancer thermo-chemotherapy. / Li, Zhenglin; Hu, Ying; Jiang, Tingting; Howard, Ken; Li, Yonggang; Fan, Xuelei; Sun, Ye; Besenbacher, Flemming; Yu, Miao.

    In: Particle & Particle Systems Characterization, Vol. 33, No. 1, 2016, p. 53-62.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  35. Published

    Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours. / Martirosyan, A; Olesen, M J; Fenton, R A; Kjems, J; Howard, K A.

    In: Nanoscale, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    Multifunctional bismuth selenide nanocomposites for anti-tumor thermo-chemotherapy and imaging. / Li, Zhenglin; Hu, Ying; Howard, Ken; Yiang, Tingting; Fan, Xuelei; Miao, Zhaohua; Sun, Ye; Besenbacher, Flemming; Yu, Miao.

    In: A C S Nano, Vol. 10, No. 1, 2016, p. 984-997.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    Multimodal Imaging-Guided Antitumor Photothermal Therapy and Drug Delivery Using Bismuth Selenide Spherical-Sponge. / Li, Zhenglin ; Liu, Jing; Howard, Ken; Fan, Xuelei; Chang, Manli; Sun, Ye; Besenbacher, Flemming; Yu, Miao.

    In: A C S Nano, Vol. 10, No. 10, 2016, p. 9646–9658.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Nanomedicine: Working towards defining the field. / Howard, Ken.

    Nanomedicine. ed. / Kenneth A. Howard; Thomas Vorup-Jensen; Dan Peer. Springer, 2016. p. 1-12 (Advances in Delivery Science and Technology).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  39. Published

    Neonatal Fc Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants. / Petersen, Steffan; Kläning, Eva; Andersen, Birgitte; Cameron, Jason; Sørensen, Esben Skipper; Howard, Ken.

    In: Molecular Pharmaceutics, Vol. 13, No. 2, 2016, p. 677–682.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. 2015
  41. Published

    Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness. / Whitehead, Bradley Joseph; Wu, Linping; Hvam, Michael Lykke; Aslan, Hüsnü; Dong, Mingdong; Dyrskjøt, Lars; Ostenfeld, Marie Stampe; Moein Moghimi, Seyed; Howard, Ken.

    In: Journal of Extracellular Vesicles, Vol. 4, 29685, 28.12.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. Published

    Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells. / Ebbesen, Morten Frendø; Olesen, Morten Tobias Jarlstad; Gjelstrup, Mikkel Carstensen; Pakula, Malgorzata Maria; Larsen, Esben Ku; Hansen, Irene M; Hansen, Pernille L; Mollenhauer, Jan; Malle, Birgitte M; Howard, Ken.

    In: Pharmaceutical Research, Vol. 32, No. 4, 01.11.2015, p. 1462-1474.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Albumin : The next-generation delivery technology. / Howard, Kenneth A.

    In: Therapeutic Delivery, Vol. 6, No. 3, 01.04.2015, p. 265-268.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Accepted/In press

    Selective cellular removal of miR23b by Rab27a/b-dependent exosome release is linked to acquisition of a metastatic property in bladder cancer. / Ostenfeld, Marie Stampe; Jeppesen, Dennis Kjølhede; Bramsen, Jesper Bertram; Laurberg, Jens Reumert; Howard, Ken; Dyrskjøt, Lars; Ørntoft, Torben Falck.

    In: Cancer Research, 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. 2014
  46. Published

    Comparative analysis of discrete exosome fractions obtained by differential centrifugation. / Jeppesen, Dennis Kjølhede; Hvam, Michael L; Primdahl-Bengtson, Bjarke; Boysen, Anders T; Whitehead, Bradley; Dyrskjøt, Lars; Orntoft, Torben F; Howard, Ken; Ostenfeld, Marie S.

    In: Journal of Extracellular Vesicles, Vol. 3, 25011, 06.11.2014, p. 1-16.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. / Whitehead, Bradley Joseph; Hvam, Michael Lykke; Bienk, Konrad; Ostenfeld, Marie Stampe; Howard, Ken.

    2014. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.

    Research output: Contribution to conferencePosterResearch

  48. Published

    Inflammatory response of RAW 264.7 cells to ultraporous interweaving PCL-PEO electrospun microfibers. / Rubert, M.; Fang-Li, Y.; Aslan, H.; Yu, Y.; Howard, K. A.; Dong, MD; Besenbacher, F.; Chen, M.

    In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 8, 06.2014, p. 249-249.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells. / Yang, Hsiao Yin; Vonk, Lucienne A.; Licht, Ruud; Van Boxtel, Antonetta M G; Bekkers, Joris E J; Kragten, Angela H M; Hein, San; Varghese, Oommen P.; Howard, Ken; Cumhur Öner, F.; Dhert, Wouter J A; Creemers, Laura B.

    In: European Journal of Pharmaceutical Sciences, Vol. 53, No. 1, 12.03.2014, p. 35-44.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes. / Miclaus, Teodora; Bochenkov, Vladimir; Ogaki, Ryosuke; Howard, Ken; Sutherland, Duncan S.

    In: Nano Letters, Vol. 14, No. 4, 11.03.2014, p. 2086-2093.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. Published

    Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors. / Jeppesen, Dennis Kjølhede; Nawrocki, Arkadiusz; Jensen, Steffen Grann; Thorsen, Kasper; Whitehead, Bradley; Howard, Ken; Andersen, Lars Dyrskjøt; Orntoft, Torben Falck; Larsen, Martin R; Ostenfeld, Marie Stampe.

    In: Proteomics, Vol. 14, No. 6, 03.2014, p. 699-712.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. Published

    RNA interference-based Therapeutics and Diagnostics. / Peer, Dan; Howard, Ken.

    In: Drug Delivery and Translational Research, Vol. 4, No. 1, 02.2014, p. 1-2.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  53. Published

    The application of RNAi-based treatments for inflammatory bowel disease. / Olesen, Morten Tobias Jarlstad; Gonzalez, Borja Ballarin; Howard, Ken.

    In: Drug Delivery and Translational Research, Vol. 4, No. 1, 02.2014, p. 4-18.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. Published

    Extended blood circulation and accumulation of a p(HPMA-co-AzMA)-based nanoconjugate in a murine model of rheumatoid arthritis. / Ebbesen, Morten; Bienk, Konrad; Deleuran, Bent Winding; Howard, Ken.

    In: Molecular and Cellular Therapies, Vol. 2, No. 29, 2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  55. Published

    Extended circulation and accumulation of p(HPMA-co-AzMA) and accumulation in arthritic joints. / Ebbesen, Morten Frendø; Bienk, Konrad; Deleuran, Bent Winding; Howard, Ken.

    2014. Poster session presented at 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014 Chicago, USA , Chicago, United States.

    Research output: Contribution to conferencePosterResearch

  56. Published

    Mucus barrier-triggered disassembly of siRNA nanocarriers. / Thomsen, Troels Bo; Li, Leon; Howard, Ken.

    In: Nanoscale, Vol. 6, No. 21, 2014, p. 12547-54.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  57. Published

    Polycation-based nanoparticles for RNAi-mediated cancer treatment. / Gonzalez, Borja Ballarin; Ebbesen, M.F.; Howard, Ken.

    In: Cancer Letters, Vol. 352, 2014, p. 66-80.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  58. Published

    Ultraporous interweaving electrospun microfibers from PCL-PEO binary blends and their inflammatory responses. / Li, Yanfang Y.; Femenias, Marina Rubert; Aslan, Hüsnü H.; Yu, Ying Y.; Howard, Ken; Dong, MD; Besenbacher, Flemming F.; Chen, Menglin M.

    In: Nanoscale, Vol. 6, No. 6, 2014, p. 3392-3402.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  59. 2013
  60. Published

    Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications. / Ebbesen, Morten F; Schaffert, D.H.; Crowley, Michael L; Oupický, David; Howard, Ken.

    In: Journal of Polymer Science. Part A, Polymer Chemistry, Vol. 51, No. 23, 01.12.2013, p. 5091-5099.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  61. Published

    Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors. / Ebbesen, M F; Whitehead, Bradley Joseph; Gonzalez, Borja Ballarin; Kingshott, P; Howard, Ken.

    In: Pharmaceutical Research, Vol. 30, No. 7, 01.07.2013, p. 1758-1767.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  62. Published

    Bioresponsive nanoparticles for the intracellular delivery of RNAi therapeutics. / Howard, Ken.

    Nanotechnology for the Delivery of Therapeutic Nucleic Acids. Pan Stanford Publishing, 2013. p. 129-151.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  63. Published

    Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model. / Nawroth, Isabel; Alsner, Jan; Deleuran, B.W.; Dagnæs-Hansen, Frederik; Yang, Chuanxu; Horsman, Michael Robert; Overgaard, Jens; Howard, Ken; Kjems, Jørgen; Gao, Shan.

    In: Acta Oncologica, Vol. 52, No. 8, 01.01.2013, p. 1730-1738.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  64. Published

    Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles. / Gonzalez, Borja Ballarin; Dagnæs-Hansen, Frederik; Fenton, Robert A.; Gao, Shan; Hein, San; Dong, Mingdong; Kjems, Jørgen; Howard, Kenneth A.

    In: Molecular Therapy - Nucleic Acids, Vol. 2, No. 1, e76, 01.01.2013, p. 1-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  65. Published
  66. Published

    Clinical translation of RNAi-based treatments for respiratory diseases. / Gonzalez, Borja Ballarin; Thomsen, Troels Bo; Howard, Ken.

    In: Drug Delivery and Translational Research, Vol. 3, No. 1, 2013, p. 84-99.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  67. Published

    Mucosal Delivery of RNAi Therapeutics. / Gonzalez, Borja Ballarin; Nielsen, Ebbe Juel Bech; Thomsen, Troels Bo; Howard, Ken.

    RNA Interference from Biology to Therapeutics. ed. / Kenneth A. Howard. Springer, 2013. p. 97-125 (Advances in Delivery Science and Technology).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  68. Published

    Providing the full picture : A mandate for standardizing nanoparticle-based drug delivery. / Howard, Ken; Peer, Dan .

    In: Nanomedicine, Vol. 8, No. 7, 2013, p. 1031-1033.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  69. 2012
  70. Published

    Polycation-based nanoparticle delivery of RNAi therapeutics : Adverse effects and solutions. / Gonzalez, Borja Ballarin; Howard, Ken.

    In: Advanced Drug Delivery Reviews, Vol. 64, No. 15, 01.12.2012, p. 1717-1729.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  71. Published

    Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. / Chen, Menglin; Gao, Shan; Dong, Mingdong; Song, Jie; Yang, Chuanxu; Howard, Kenneth Alan; Kjems, Jørgen; Besenbacher, Flemming.

    In: A C S Nano, Vol. 6, No. 6, 26.06.2012, p. 4835-4844.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  72. Published

    Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors. / Larsen, Esben Kjær Unmack; Nielsen, Thomas; Wittenborn, Thomas; Rydtoft, Louise Munk; Lokanathan, Arcot R.; Hansen, Line; Østergaard, Leif; Kingshott, Peter; Howard, Kenneth A; Besenbacher, Flemming; Nielsen, Niels Christian; Kjems, Jørgen.

    In: Nanoscale, Vol. 4, No. 7, 06.03.2012, p. 2352-2361 .

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  73. Published

    Oligonucleotide delivery to the lung : waiting to inhale. / Kjems, Jørgen; Howard, Ken.

    In: Molecular Therapy - Nucleic Acids, Vol. 1, 2012, p. e1.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debateResearchpeer-review

  74. 2011
  75. Published

    Antimicrobial effect of chitosan nanoparticles on streptococcus mutans biofilms. / de Paz, Luis; Resin, Anton; Howard, Ken; Sutherland, Duncan S; Wejse, Peter.

    In: Applied and Environmental Microbiology, Vol. 77, No. 11, 06.2011, p. 3892-3895.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  76. 2010
  77. Published

    Bioresponsive hyperbranched polymers for siRNA and miRNA delivery. / Rahbek, Ulrik L; Nielsen, Anne F; Dong, Mingdong; You, Yezi; Chauchereau, Anne; Oupicky, David; Besenbacher, Flemming; Kjems, Jørgen; Howard, Kenneth A.

    In: Journal of Drug Targeting, Vol. 18, No. 10, 01.12.2010, p. 812-20.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  78. Published

    Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth. / Mittnacht, Ursula; Hartmann, Hanna; Hein, San; Oliveira, Hugo; Dong, Mingdong; Pêgo, Ana P; Kjems, Jørgen; Howard, Kenneth A; Schlosshauer, Burkhard.

    In: Nano Letters, Vol. 10, No. 10, 13.10.2010, p. 3933-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  79. Published

    Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis. / Nawroth, Isabel; Alsner, Jan; Behlke, Mark A; Besenbacher, Flemming; Overgaard, Jens; Howard, Kenneth A; Kjems, Jørgen.

    In: Radiotherapy & Oncology, Vol. 97, No. 1, 01.10.2010, p. 143-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  80. Published

    Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles. / Nielsen, Ebbe J B; Nielsen, Jan Møller; Becker, Daniel; Karlas, Alexander; Prakash, Hridayesh; Glud, Sys Z; Merrison, Jonathan; Besenbacher, Flemming; Meyer, Thomas F; Kjems, Jørgen; Howard, Kenneth A.

    In: Pharmaceutical Research, Vol. 27, No. 12, 2010, p. 2520-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  81. Published
  82. Published

    siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. / Andersen, Morten Ø; Nygaard, Jens V; Burns, Jorge S; Raarup, Merete K; Nyengaard, Jens R; Bünger, Cody; Besenbacher, Flemming; Howard, Kenneth A; Kassem, Moustapha; Kjems, Jørgen.

    In: Molecular Therapy, Vol. 18, No. 11, 2010, p. 2018-2027.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  83. 2009
  84. Published

    Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. / Hartmann, Hanna; Lakner, Ursula; Andersen, Morten Østergaard; Kjems, Jørgen; Howard, Kenneth Alan; Schloßhauer, Burkhard.

    In: Tissue Engineering. Part A. Tissue Engineering, No. 3, 2009, p. 718.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  85. Published

    Delivering the goods; realising the clinical potential of RNA interference. / Howard, Ken.

    In: Nanomedicine, Vol. 4, No. 6, 2009, p. 595-598.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  86. Published

    Delivery of RNA interference therapeutics using polycation-based nanoparticles. / Howard, Ken.

    In: Advanced Drug Delivery Reviews, Vol. 61 , No. 9, 2009, p. 710-720.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  87. Published

    Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium. / Mistry, Alpesh; Glud, Sys Zoffmann; Kjems, Jørgen; Nyengaard, Jens Randel; Howard, Kenneth Alan; Stolnik, Snjezana; Illum, Lisbeth.

    In: Journal of Drug Evaluation, Vol. 17, No. 7, 2009, p. 543-552.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  88. Published

    Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration. / Glud, Sys Zoffmann; Bramsen, Jesper B; Dagnaes-Hansen, Frederik; Wengel, Jesper; Howard, Kenneth Alan; Nyengaard, Jens R; Kjems, Jørgen.

    In: Oligonucleotides, Vol. 19, No. 2, 2009, p. 163-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  89. Published

    RNAi using a chitosan/siRNA nanoparticle system : in vitro and in vivo applications. / Andersen, Morten Østergaard; Howard, Kenneth Alan; Kjems, Jørgen.

    Methods in Molecular Biology. Vol. 555 2009. p. 77-86 (Methods in Molecular Biology).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  90. Published

    Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors. / Larsen, Esben Kjær Unmack; Nielsen, Thomas; Wittenborn, Thomas; Birkedal, Henrik; Vorup-Jensen, Thomas; Jakobsen, Mogens H; Østergaard, Leif; Horsman, Michael R; Besenbacher, Flemming; Howard, Kenneth A; Kjems, Jørgen.

    In: A C S Nano, Vol. 3, No. 7, 2009, p. 1947-51.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  91. Published

    The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. / Gao, Shan; Dagnæs-Hansen, Frederik; Nielsen, Ebbe Juel Bech; Wengel, Jesper; Besenbacher, Flemming; Howard, Kenneth Alan; Kjems, Jørgen.

    In: Molecular Therapy, Vol. 17, No. 7, 2009, p. 1225-1233.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  92. 2008
  93. Published

    Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy. / Nygaard, J V; Andersen, M Ø; Howard, K A; Foss, M; Bünger, Cody; Kjems, J; Besenbacher, F.

    In: Biotechnology and Bioengineering (Print), Vol. 100, No. 4, 01.07.2008, p. 820-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  94. Published

    Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. / Howard, Kenneth Alan; Paludan, Søren R; Behlke, Mark A; Besenbacher, Flemming; Deleuran, Bent Winding; Kjems, Jørgen.

    In: Molecular Therapy, Vol. 17, No. 1, 2008, p. 162-168.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  95. Published

    Delivery of siRNA from lyophilized polymeric surfaces. / Andersen, Morten Ø; Howard, Kenneth A; Paludan, Søren R; Besenbacher, Flemming; Kjems, Jørgen.

    In: Biomaterials, Vol. 29, No. 4, 2008, p. 506-512.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  96. Published

    Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides. / Rahbek, Ulrik L; Howard, Kenneth A; Oupicky, David; Manickam, Devika S; Dong, Mingdong; Nielsen, Anne F; Hansen, Thomas B; Besenbacher, Flemming; Kjems, Jørgen.

    In: Journal of Gene Medicine, Vol. 10, No. 1, 2008, p. 81-93.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  97. 2007
  98. Published

    Direct force measurements between siRNA and chitosan molecules using force spectroscopy. / Xu, Sailong; Dong, Mingdong; Liu, Xiudong; Howard, Kenneth A; Kjems, Jørgen; Besenbacher, Flemming.

    In: Biophysical Journal, Vol. 93, No. 3, 2007, p. 952-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  99. Published

    Localized Delivery of Lyophilized siRNA polyplexes. / Bak, Rasmus Otkjær; Andersen, Morten Østergaard; Howard, Kenneth Alan; Kjems, Jørgen.

    2007. Poster session presented at INASCON, Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  100. Published

    Nanocarrier stimuli-activated gene delivery. / Howard, Kenneth A; Dong, Mingdong; Oupicky, David; Bisht, Harender S; Buss, Claus; Besenbacher, Flemming; Kjems, Jørgen.

    In: Small, Vol. 3, No. 1, 2007, p. 54-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  101. Published

    Polycation-based nanoparticle delivery for improved RNA interference therapeutics. / Howard, Kenneth A; Kjems, Jørgen.

    In: Expert opinion on biological therapy, Vol. 7, No. 12, 2007, p. 1811-1822.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  102. Published

    Polycation-based nanoparticle delivery for improved RNAi therapeutics. / Howard, Kenneth Alan; Kjems, Jørgen.

    In: Expert Opin. Biol. Ther, Vol. 7, 2007, p. 1811-1822.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  103. Published

    Surface delivery of siRNA for implants. / Andersen, Morten Østergaard; Nygaard, Jens Vinge; Howard, Ken; Bak, Rasmus Otkjær; Paludan, Søren Riis; Raarup, Merete krog; Besenbacher, Flemming; Kjems, Jørgen.

    In: European Cells & Materials, Vol. 14, No. 3, 2007, p. 118.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  104. Published

    The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. / Liu, Xiudong; Howard, Kenneth A; Dong, Mingdong; Andersen, Morten Ø; Rahbek, Ulrik L; Johnsen, Mads G; Hansen, Ole C; Besenbacher, Flemming; Kjems, Jørgen.

    In: Biomaterials, Vol. 28, No. 6, 2007, p. 1280-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  105. Published

    Visualization of thermally activated nanocarriers using in situ atomic force microscopy : Nanotechnology. / Dong, M. D.; Howard, K. A.; Oupicky, D.; Bisht, H.; Kjems, J.; Besenbacher, F.

    In: Nanotechnology, Vol. 18, No. 18, 2007.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  106. 2006
  107. Published
  108. Published

    RNA interference in Vitro and in Vivo using a novel chitosan/siRNA nanoparticle system. / Howard, Kenneth A; Rahbek, Ulrik L; Liu, Xiudong; Damgaard, Christian Kroun; Glud, Sys Zoffmann; Andersen, Morten Ø; Hovgaard, Mads Bruun; Schmitz, Alexander; Nyengaard, Jens R; Besenbacher, Flemming; Kjems, Jørgen.

    In: Molecular Therapy, Vol. 14, No. 4, 2006, p. 476-484.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  109. 2004
  110. Published

    Analysis of Nanoparticles in Scaffolds for Tissue Engineering by use of X-Ray Nano Tomography. / Nygaard, Jens Vinge; Andersen, Morten Østergaard; Howard, Ken; Sasov, Alexander; Kjems, Jørgen; Besenbacher, Flemming.

    2004. Poster session presented at iNANO 4th annual meeting, Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch