Kathrine Agergård Kaspersen

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

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The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease : Results from the Danish Blood Donor Study. / Dinh, Khoa M; Pedersen, Ole B; Petersen, Mikkel S; Sørensen, Erik; Sørensen, Cecilie J; Kaspersen, Kathrine A; Larsen, Margit H; Møller, Bjarne; Hjalgrim, Henrik; Ullum, Henrik; Erikstrup, Christian.

In: Atherosclerosis, Vol. 242, No. 1, 09.2015, p. 222-5.

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Dinh, Khoa M ; Pedersen, Ole B ; Petersen, Mikkel S ; Sørensen, Erik ; Sørensen, Cecilie J ; Kaspersen, Kathrine A ; Larsen, Margit H ; Møller, Bjarne ; Hjalgrim, Henrik ; Ullum, Henrik ; Erikstrup, Christian. / The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease : Results from the Danish Blood Donor Study. In: Atherosclerosis. 2015 ; Vol. 242, No. 1. pp. 222-5.

Bibtex

@article{6077aa1f30a2434b83123eb0ee2d869e,
title = "The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study",
abstract = "BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.",
author = "Dinh, {Khoa M} and Pedersen, {Ole B} and Petersen, {Mikkel S} and Erik S{\o}rensen and S{\o}rensen, {Cecilie J} and Kaspersen, {Kathrine A} and Larsen, {Margit H} and Bjarne M{\o}ller and Henrik Hjalgrim and Henrik Ullum and Christian Erikstrup",
note = "Copyright {\textcopyright} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = sep,
doi = "10.1016/j.atherosclerosis.2015.07.031",
language = "English",
volume = "242",
pages = "222--5",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease

T2 - Results from the Danish Blood Donor Study

AU - Dinh, Khoa M

AU - Pedersen, Ole B

AU - Petersen, Mikkel S

AU - Sørensen, Erik

AU - Sørensen, Cecilie J

AU - Kaspersen, Kathrine A

AU - Larsen, Margit H

AU - Møller, Bjarne

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Erikstrup, Christian

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

AB - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

U2 - 10.1016/j.atherosclerosis.2015.07.031

DO - 10.1016/j.atherosclerosis.2015.07.031

M3 - Journal article

C2 - 26222902

VL - 242

SP - 222

EP - 225

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -