Kathrine Agergård Kaspersen

The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

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  • Sabina Chaudhary Hauge, University of Copenhagen
  • ,
  • Charlotte Kaestel Jensen, University of Copenhagen
  • ,
  • Leif Kofoed Nielsen, University of Copenhagen, 3 Department of Technology, Faculty of Health and Technology, Metropolitan University College , Copenhagen, Denmark .
  • ,
  • Ole B Pedersen, Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.
  • ,
  • Erik Sørensen, University of Copenhagen
  • ,
  • Lise Wegner Thørner, University of Copenhagen
  • ,
  • Henrik Hjalgrim, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Christian Erikstrup
  • Kaspar René Nielsen
  • Kathrine Agergård Kaspersen
  • Maria Didriksen, University of Copenhagen
  • ,
  • Morten Dziegiel, University of Copenhagen
  • ,
  • Henrik Ullum, University of Copenhagen

The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.

Original languageEnglish
Book seriesAPMIS Supplementum
Pages (from-to)248-256
Number of pages9
Publication statusPublished - Mar 2018

    Research areas

  • Adult, Blood Donors, C-Reactive Protein/metabolism, Denmark/epidemiology, Diagnostic Self Evaluation, Female, Genetic Predisposition to Disease, Humans, IgA Deficiency/genetics, Immunoglobulin A/genetics, Infection/epidemiology, Male, Middle Aged, Risk, Surveys and Questionnaires, Young Adult

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