Kathrine Agergård Kaspersen

Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Kathrine Agergård Kaspersen
  • Lotte Aas Hindhede
  • Jens Kjærgaard Boldsen
  • Susan Mikkelsen
  • Lasse Skafte Vestergaard, Statens Serum Institut
  • ,
  • Ann-Sofie Nicole Berthelsen, Statens Serum Institut
  • ,
  • Ida Rask Moustsen-Helms, Statens Serum Institut
  • ,
  • Dorte Kinggaard Holm, Department of Clinical Immunology, Odense University Hospital
  • ,
  • Anna Christine Nilsson, Department of Clinical Immunology, Odense University Hospital
  • ,
  • Susanne Gjørup Sækmose, Department of Clinical Immunology, Zealand University Hospital, Naestved, Denmark
  • ,
  • Erik Sørensen, Department of Clinical Immunology, Copenhagen University Hospital.
  • ,
  • Lene Holm Harritshøj, Department of Clinical Immunology, Copenhagen University Hospital.
  • ,
  • Bitten Aagaard, Department of Clinical Immunology, Aalborg University Hospital
  • ,
  • Henrik Hjalgrim, Statens Serum Institut
  • ,
  • Søren Thue Lillevang, Department of Clinical Immunology, Odense University Hospital
  • ,
  • Charlotte Sværke Jørgensen, Statens Serum Institut
  • ,
  • Tyra Grove Krause, Statens Serum Institut
  • ,
  • Henrik Ullum, Statens Serums Institut
  • ,
  • Ole Birger Vestager Pedersen, Department of Clinical Immunology, Zealand University Hospital, Naestved, Denmark, Department of Clinical Medicine, University of Copenhagen
  • ,
  • Sisse Rye Ostrowski, Department of Clinical Immunology, Copenhagen University Hospital., Department of Clinical Medicine, University of Copenhagen
  • ,
  • Christian Erikstrup

Background. Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality.

Methods. Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark.

Results. In total, 84 944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3 898 039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people < 51 years without comorbidity during the 2 waves (combined IFR = 3.36 per 100 000 infections). The IFR was below 3 parts per thousand for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave.

Conclusions. In this nationwide study, the IFR was very low among people < 51 years without comorbidity.

Original languageEnglish
JournalThe Journal of Infectious Diseases
Volume225
Issue2
Pages (from-to)219-228
Number of pages10
ISSN0022-1899
DOIs
Publication statusPublished - Jan 2022

    Research areas

  • SARS-CoV-2, blood donors, infection fatality rate, seroprevalence, Antibodies, Viral/blood, SARS-CoV-2/isolation & purification, Comorbidity, Humans, Middle Aged, Male, Seroepidemiologic Studies, COVID-19/blood, Young Adult, Blood Donors, Denmark/epidemiology, Adolescent, Adult, Female, Aged

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