Aarhus University Seal / Aarhus Universitets segl

Karl Anker Jørgensen

Enantioselective Oxidative Coupling of Carboxylic Acids to α-Branched Aldehydes

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

A new reactivity in organocatalysis is proposed to account for the coupling of carboxylic acids to α-branched aldehydes by combining primary amine catalysis and an oxidant. The developed methodology is an enantioselective α-coupling of aromatic and aliphatic carboxylic acids to α-branched aldehydes and proceeds in high yields (up to 97%) and for most examples good enantioselectivities (up to 92% ee). On the basis of experimental and mechanistic observations, the role of the primary amine catalyst is discussed.

Original languageEnglish
JournalJournal of the American Chemical Society
Volume140
Issue40
Pages (from-to)12687-12690
Number of pages4
ISSN0002-7863
DOIs
Publication statusPublished - 1 Jan 2018

See relations at Aarhus University Citationformats

ID: 134260139