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Karl Anker Jørgensen

Asymmetric Formation of Bridged Benzoxazocines through an Organocatalytic Multicomponent Dienamine-Mediated One-Pot Cascade

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  • Lars Krogager Ransborg, Denmark
  • Mette Kiilerich Overgaard, Denmark
  • Joanna Hejmanowska, Lodz Technical University, Poland
  • Sebastian Barfüsser, Denmark
  • Karl Anker Jørgensen
  • Lukasz Karol Albrecht, Lodz Technical University, Denmark
An organocatalytic one-pot cascade leading to the stereoselective formation of novel bridged benzoxazocines is presented. The developed methodology is based on the first example of a γ-selective-Mannich-initiated cascade reaction and allows for direct annulation of the bridged benzoxazocines by incorporation of various α,β-unsaturated aldehydes, electron-rich anilines, and electron-deficient salicylaldehydes. The synthetic applicability of the products is demonstrated by relevant transformations.
Original languageEnglish
JournalOrganic Letters
Pages (from-to)4182-4185
Number of pages4
Publication statusPublished - 15 Aug 2014

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