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Karl Anker Jørgensen

A New Organocatalytic Concept for Asymmetric alpha-Alkylation of Aldehydes

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  • Lorenzo Caruana, Denmark
  • Florian Kniep, Denmark
  • Tore Kiilerich Johansen, Denmark
  • Pernille H. Poulsen, Denmark
  • Karl Anker Jorgensen
The organocatalytic asymmetric alpha-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts, alpha-diarylmethine-substituted aldehydes with two contiguous stereocenters have been synthesized in a simple manner with good diastereocontrol and excellent enantioselectivity.
Original languageEnglish
JournalJournal of the American Chemical Society
Volume136
Issue45
Pages (from-to)15929-15932
Number of pages4
ISSN0002-7863
DOIs
Publication statusPublished - 12 Nov 2014

    Research areas

  • P-QUINONE-METHIDE, PHOTOREDOX CATALYSIS, CYCLIC-KETONES, ACTIVATION, GENERATION, ALCOHOLS, LIGHT, BIOSYNTHESIS

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