Karl Anker Jørgensen

A cleavable azide resin for direct click chemistry mediated enrichment of alkyne-labeled proteins

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The direct conjugation of a labeled proteome to a cleavable azide resin utilizing the copper-catalyzed azide alkyne cycloaddition is demonstrated. The procedure omits the classical streptavidin- and biotin-based affinity enrichment step and represents an operationally simpler, cheaper and less contaminated alternative for protein purification.

Original languageEnglish
JournalChemical Communications
Volume50
Issue81
Pages (from-to)12098-12100
ISSN1359-7345
DOIs
Publication statusPublished - 2014

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