Karina Dalsgaard Sørensen

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jayaram Vijayakrishnan, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • James Studd, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • Peter Broderick, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • Ben Kinnersley, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • Amy Holroyd, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • Philip J Law, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • Rajiv Kumar, Division of Molecular Genetic Epidemiology, German Cancer Research Centre, 69120, Heidelberg, Germany.
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  • James M Allan, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
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  • Christine J Harrison, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
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  • Anthony V Moorman, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
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  • Ajay Vora, Department of Haematology, Great Ormond Street Hospital, London, WC1N 3JH, UK.
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  • Eve Roman, Department of Health Sciences, University of York, York, YO10 5DD, UK.
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  • Sivaramakrishna Rachakonda, Division of Molecular Genetic Epidemiology, German Cancer Research Centre, 69120, Heidelberg, Germany.
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  • Sally E Kinsey, Department of Paediatric and Adolescent Haematology and Oncology, Leeds General Infirmary, Leeds, LS1 3EX, UK.
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  • Eamonn Sheridan, Medical Genetics Research Group, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, UK.
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  • Pamela D Thompson, Paediatric and Familial Cancer Research Group, Institute of Cancer Sciences, St. Mary's Hospital, Manchester, M13 9WL, UK.
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  • Julie A Irving, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
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  • Rolf Koehler, Department of Human Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
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  • Per Hoffmann, Department of Biomedicine, Human Genomics Research Group, University Hospital and University of Basel, 4031, Basel, Switzerland.
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  • Markus M Nöthen, Department of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn, D-53012, Bonn, Germany.
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  • Stefanie Heilmann-Heimbach, Department of Genomics, Institute of Human Genetics, Life & Brain Centre, University of Bonn, D-53012, Bonn, Germany.
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  • Karl-Heinz Jöckel, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
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  • Douglas F Easton, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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  • Paul D P Pharaoh, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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  • Alison M Dunning, Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.
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  • Julian Peto, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
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  • Frederico Canzian, Genomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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  • Anthony Swerdlow, Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
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  • Rosalind A Eeles, Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
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  • ZSofia Kote-Jarai, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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  • Kenneth Muir, Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom.
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  • Nora Pashayan, Department of Applied Health Research, University College London, London, WC1E 7HB, UK.
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  • Mel Greaves, Centre for Evolution and Cancer, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
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  • Martin Zimmerman, Department of Paediatric Haematology and Oncology, Hannover Medical School, 30625, Hannover, Germany.
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  • Claus R Bartram, Department of Human Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
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  • Martin Schrappe, General Paediatrics, University Hospital Schleswig-Holstein, 24105, Kiel, Germany.
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  • Martin Stanulla, Department of Paediatric Haematology and Oncology, Hannover Medical School, 30625, Hannover, Germany.
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  • Kari Hemminki, Center for Primary Health Care Research, Lund University, 221 00, Lund, Sweden.
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  • Richard S Houlston, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK. richard.houlston@icr.ac.uk.
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  • The PRACTICAL Consortium

Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.

Original languageEnglish
JournalNature Communications
Volume9
Issue1
Pages (from-to)1340
ISSN2041-1723
DOIs
Publication statusPublished - 9 Apr 2018

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