Karina Dalsgaard Sørensen

5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Gitte Kristensen, Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. gittekristensen01@gmail.com.
  • ,
  • Siri Strand
  • Martin Andreas Røder, Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. andreasroder@gmail.com.
  • ,
  • Kasper Drimer Berg, Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. kasperdrimerberg@gmail.com.
  • ,
  • Birgitte Grønkær Toft, Department of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. birgitte.groenkaer.toft@regionh.dk.
  • ,
  • Søren Høyer
  • ,
  • Michael Borre
  • Karina Dalsgaard Sørensen
  • Klaus Brasso, Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. klaus.brasso@regionh.dk.

This study aimed to validate whether 5-hydroxymethylcytosine (5hmC) level in combination with ERG expression is a predictive biomarker for biochemical failure (BF) in men undergoing radical prostatectomy (RP) for prostate cancer (PCa). The study included 592 PCa patients from two consecutive Danish RP cohorts. 5hmC level and ERG expression were analyzed using immunohistochemistry in RP specimens. 5hmC was scored as low or high and ERG was scored as negative or positive. Risk of BF was analyzed using stratified cumulative incidences and multiple cause-specific Cox regression using competing risk assessment. Median follow-up was 10 years (95% CI: 9.5⁻10.2). In total, 246 patients (41.6%) had low and 346 patients (58.4%) had high 5hmC level. No significant association was found between 5hmC level or ERG expression and time to BF (p = 0.2 and p = 1.0, respectively). However, for men with ERG negative tumors, high 5hmC level was associated with increased risk of BF following RP (p = 0.01). In multiple cause-specific Cox regression analyses of ERG negative patients, high 5hmC expression was associated with time to BF (HR: 1.8; 95% CI: 1.2⁻2.7; p = 0.003). In conclusion, high 5hmC level was correlated with time to BF in men with ERG negative PCa, which is in accordance with previous results.

Original languageEnglish
Article number1025
JournalInternational Journal of Molecular Sciences
Volume20
Issue5
Number of pages12
ISSN1661-6596
DOIs
Publication statusPublished - 2019

    Research areas

  • 5hmC, ACTIVE-SURVEILLANCE, DNA, EPIGENETICS, ERG, GLOBAL 5-HYDROXYMETHYLCYTOSINE, OUTCOMES, PROTEIN EXPRESSION, REARRANGEMENT, RECURRENCE, RISK, STRAIGHTFORWARD, predictive biomarkers, prostate cancer, radical prostatectomy

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