Karin Hjorthaug

FDG-PET/CT after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: Results of a Nordic/US intergroup study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Karen Juul Mylam
  • ,
  • Lale Kostakoglu, Unknown
  • Martin Hutchings
  • ,
  • Morton Coleman, Unknown
  • Dominic Lamonica, Unknown
  • Myron S Czuczman, Unknown
  • Louis F Diehl, Unknown
  • Anne L Nielsen, Denmark
  • Paw Jensen, Denmark
  • Annika Loft
  • ,
  • Helle W Hendel, Unknown
  • Victor Iyer, Denmark
  • Sirpa Leppä, Unknown
  • Sirkku Jyrkkiö, Unknown
  • Harald Holte
  • ,
  • Mikael Eriksson
  • ,
  • Dorte Gillstrøm
  • ,
  • Per B Hansen, Unknown
  • Marko Seppänen, Unknown
  • Karin Hjorthaug
  • Peter de Nully Brown
  • ,
  • Lars M Pedersen, Denmark

ABSTRACT We evaluated the predictive value of I-PET after one course of chemoimmunotherapy in patients with newly diagnosed DLBCL. 112 DLBCL patients were enrolled. All patients had PET/CT scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International harmonization project criteria (IHP) and to Deauville 5 point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D5PS=5). Ratios of tumorSUVmax to liverSUVmax were also analyzed. We found no difference in progression-free survivals (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS=5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p=0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish a D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET positive and PET negative patients in different prognostic groups.

Original languageEnglish
JournalLeukemia and Lymphoma
Pages (from-to)1-28
Number of pages28
ISSN1042-8194
DOIs
Publication statusPublished - 2014

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