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June Anita Ejlersen

Diagnostic test accuracy study of 18F-sodium fluoride PET/CT, 99mTc-labelled diphosphonate SPECT/CT, and planar bone scintigraphy for diagnosis of bone metastases in newly diagnosed, high-risk prostate cancer

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  • Randi F Fonager, Aalborg University, Denmark
  • Helle D Zacho, Aalborg University
  • ,
  • Niels C Langkilde
  • ,
  • Joan Fledelius
  • June A Ejlersen
  • Christian Haarmark, Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark.
  • ,
  • Helle W Hendel, Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark.
  • ,
  • Mine Benedicte Lange, University of Copenhagen
  • ,
  • Mads R Jochumsen
  • Jesper C Mortensen, Department of Nuclear Medicine, Regional Hospital West Jutland, Herning
  • ,
  • Lars J Petersen

The aim of this study was to prospectively compare planar, bone scan (BS) versus SPECT/CT and NaF PET/CT in detecting bone metastases in prostate cancer. Thirty-seven consecutive, newly diagnosed, prostate cancer patients with prostate specific antigen (PSA) levels ≥ 50 ng/mL and who were considered eligible for androgen-deprivation therapy (ADT) were included in this study. BS, SPECT/CT, and NaF PET/CT, were performed prior to treatment and were repeated after six months of ADT. Baseline images from each index test were independently read by two experienced readers. The reference standard was based on a consensus decision made by a multidisciplinary team on the basis of baseline and follow-up images of the index tests, the findings of the baseline index tests by the experienced readers, and any available imaging, biochemical, and clinical data, including the response to ADT. Twenty-seven (73%) of the 37 patients had bone metastases according to the reference standard. The sensitivities for BS, SPECT/CT and NaF PET/CT were 78%, 89%, and 89%, respectively, and the specificities were 90%, 100%, and 90%, respectively. The positive predictive values of BS, SPECT/CT and NaF PET/CT were 96%, 100%, and 96%, respectively, and the negative predictive values were 60%, 77% and 75%, respectively. No statistically significant difference among the three imaging modalities was observed. All three imaging modalities showed high sensitivity and specificity. NaF PET/CT and SPECT/CT showed numerically improved, but not statistically superior, sensitivity compared with BS in this limited and selected patient cohort.

Original languageEnglish
JournalAmerican Journal of Nuclear Medicine and Molecular Imaging
Pages (from-to)218-227
Number of pages10
Publication statusPublished - 2017

    Research areas

  • Journal Article

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