Projects per year
Personal profile
Research
Studies of transport mechanism, structure, regulation, and pathophysiology of ion pumps and lipid pumps (P-type ATPases: Ca-ATPase, Na,K-ATPase and phospholipid flippases) in cell membranes. Site-directed mutagenesis is combined with state-of-the-art enzyme kinetic measurements on mutant pump proteins expressed in cell culture to elucidate the mechanistic roles of the individual amino acid residues in the transport and the basis for genetic disorders caused by mutations in these proteins.
Profile
1995- Professor of Physiology and Biomedicine, AU.
2007 Knight of Dannebrog.
By 2025 author of >150 internationally published articles. H-index 50.
Invited plenary speaker at >60 international conferences.
Supervisor of 15 Ph.D. projects.
1990 DMSc (dr.med.).
1988-1989 Visiting professor, C.H. Best Institute, University of Toronto, Canada.
1983 MD.
1979 EMBO Short term fellowship, University of Paris.
1976 (as student) Gold medal awarded diploma thesis in Medical Biochemistry.
Cooperation and dissemination
Several of the publications have involved collaborations with other leading laboratories world wide, including Canada, Belgium, Italy, France, USA, and South Africa.
Job responsibilities
Research (professor, group leader), undergraduate and graduate teaching of medical students, supervisor of bachelor and Ph.D. students.
Keywords
- Hereditary diseases
- Cell biology
- Design of new proteins
- Physiology
- Genetics
- Membrane proteins
- Molecules and atoms
- Molecular medicine
- Molecular Biology and Biotechnology
- Molecular pumps
- Nanomedicine
- Kidneys and urinary tract
- Protein structure
Areas of expertise
- Molecular Physiology & Biochemistry
- Membrane Physiology
- Transport ATPases
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structure-function analysis of mammalian flippases studied by site-directed mutagenesis
Andersen, J. P. (Project manager), Mikkelsen, S. (Participant), Molday, R. S. (Collaborator), Vilsen, B. (Participant), Vestergaard, A. L. (Participant), Mogensen, L. (Participant), Gantzel, R. H. B. (Participant) & Tadini-Buoninsegni, F. (Collaborator)
01/08/2010 → …
Project: Research
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Struktur-funktions analyse af calcium pumpen i sarko(endo)plasmisk retikulum ved site directed mutagenese
Andersen, J. P. (Project manager), Vilsen, B. (Participant) & Mikkelsen, S. (Participant)
01/05/1988 → 30/04/2021
Project: Research
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Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2
Vestergaard, A. L., Coleman, J. A., Lemmin, T., Mikkelsen, S. A., Molday, L. L., Vilsen, B., Molday, R. S., Dal Peraro, M. & Andersen, J. P., 8 Apr 2014, In: Proceedings of the National Academy of Sciences (PNAS). 111, 14, p. E1334-43 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
95 Citations (Scopus) -
On the track of the lipid transport pathway of the phospholipid flippase ATP8A2: Mutation analysis of residues of the transmembrane segments M1, M2, M3 and M4
Mogensen, L. S., Mikkelsen, S. A., Tadini-Buoninsegni, F., Holm, R., Matsell, E., Vilsen, B., Molday, R. S. & Andersen, J. P., Jan 2024, In: B B A - Molecular Cell Research. 1871, 1, 18 p., 119570.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile7 Citations (Scopus)43 Downloads (Pure) -
Phosphatidylserine flipping by the P4-ATPase ATP8A2 is electrogenic
Tadini-Buoninsegni, F., Mikkelsen, S. A., Mogensen, L. S., Molday, R. S. & Andersen, J. P., 13 Aug 2019, In: Proceedings of the National Academy of Sciences (PNAS). 116, 33, p. 16332-16337 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access22 Citations (Scopus) -
Structural and functional properties of the N- and C-terminal segments of the P4-ATPase phospholipid flippase ATP8A2
Matsell, E., Mazaheri, M., Andersen, J. P. & Molday, R. S., Jan 2025, In: The Journal of Biological Chemistry. 301, 1, p. 108065 108065.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Review: P4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas
Andersen, J. P., Vestergaard, A. L., Mikkelsen, S. A., Mogensen, L. S., Chalat, M. & Molday, R. S., 8 Jul 2016, In: Frontiers in Physiology. 7, JUL, p. 275 (23 pages) 23 p., 275.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
246 Citations (Scopus)
Activities
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Plenary speaker at 16th International Conference on Na,K-ATPase and Related Transport ATPases "P-Type ATPases in Health and Disease" September 2022 in Banff, Alberta, Canada. Title of talk: "Mechanism and Transport Pathway of the P4-ATPase ATP8A2 by Mutagenesis"
Andersen, J. P. (Lecturer)
9 Sept 2022Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
File -
On the track of the lipid transport pathway of the phospholipid flippase ATP8A2 (plenary lecture at The 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan, September 24-30, 2017)
Andersen, J. P. (Lecturer)
27 Sept 2017Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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Phospholipid flippases: Structure and Function – how different are they from ion pumps? (Lecture at Ph.D. Course on Biological Membranes, Drug Targets and Absorption Barriers, Faculty of Health and Medical Sciences, University of Copenhagen)
Andersen, J. P. (Lecturer)
2 Nov 2016Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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Mechanism of Phospholipid Transport by the Mammalian P4-ATPase ATP8A2 Studied by Site-directed Mutagenesis (Invited plenary lecture at the 14th International Conference on Na,K-ATPase and Related Transport ATPases: Structure, Mechanism, Cell Biology, Health and Disease, Lunteren, The Netherlands, August 30 - September 5, 2014)
Andersen, J. P. (Lecturer)
4 Sept 2014Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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Mechanism of phospholipid flippase ATP8A2 by site-directed mutagenesis: Invited plenum lecture at FASEB Science Research Conference on New Frontiers in Transport ATPases : From Mechanistic to Therapeutic Concepts
Andersen, J. P. (Lecturer)
4 Jun 2012Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
Prizes
Press/Media
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Fedt-problem opklaret: Derfor går tyrkisk familie rundt på alle fire
Vestergaard, A. L., Mikkelsen, S., Vilsen, B. & Andersen, J. P.
21/05/2014
1 item of Media coverage
Press/Media: Press / Media
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Simpel pumpefunktion transporterer cellernes fedtstof
Andersen, J. P., Vestergaard, A. L. & Vilsen, B.
24/01/2012
1 item of Media coverage
Press/Media: Press / Media