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John Rosendahl Østergaard

Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy

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Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy. / Olsen, Morten; Thygesen, Sandra K; Østergaard, John R; Nielsen, Henrik; Henderson, Victor W; Ehrenstein, Vera; Nørgaard, Mette; Sørensen, Henrik Toft.

In: JAMA: The Journal of the American Medical Association, Vol. 314, No. 17, 03.11.2015, p. 1844-9.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Olsen, M, Thygesen, SK, Østergaard, JR, Nielsen, H, Henderson, VW, Ehrenstein, V, Nørgaard, M & Sørensen, HT 2015, 'Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy', JAMA: The Journal of the American Medical Association, vol. 314, no. 17, pp. 1844-9. https://doi.org/10.1001/jama.2015.13971

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MLA

Vancouver

Olsen M, Thygesen SK, Østergaard JR, Nielsen H, Henderson VW, Ehrenstein V et al. Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy. JAMA: The Journal of the American Medical Association. 2015 Nov 3;314(17):1844-9. https://doi.org/10.1001/jama.2015.13971

Author

Olsen, Morten ; Thygesen, Sandra K ; Østergaard, John R ; Nielsen, Henrik ; Henderson, Victor W ; Ehrenstein, Vera ; Nørgaard, Mette ; Sørensen, Henrik Toft. / Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy. In: JAMA: The Journal of the American Medical Association. 2015 ; Vol. 314, No. 17. pp. 1844-9.

Bibtex

@article{f5c34ef8175a4db6945b51eeae6d105a,
title = "Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy",
abstract = "IMPORTANCE: Pertussis is associated with encephalopathy and seizures in infants. However, the risk of childhood epilepsy following pertussis is unknown.OBJECTIVE: To examine whether pertussis is associated with the long-term risk of epilepsy.DESIGN, SETTING, AND PARTICIPANTS: We used individually linked data from population-based medical registries covering all Danish hospitals to identify a cohort of all patients with pertussis born between 1978 and 2011, followed up through 2011. We used the Civil Registration System to identify 10 individuals from the general population for each patient with pertussis, matched on sex and year of birth.EXPOSURES: Inpatient or hospital-based outpatient diagnosis of pertussis.MAIN OUTCOMES AND MEASURES: Cumulative incidence and hazard ratio of time to hospital-based epilepsy diagnosis (pertussis cohort vs general population cohort), adjusted for birth year, sex, maternal history of epilepsy, presence of congenital malformations, and gestational age. Unique personal identifiers permitted unambiguous data linkage and complete follow-up for death, emigration, and hospital contacts.RESULTS: We identified 4700 patients with pertussis (48% male), of whom 90 developed epilepsy during the follow-up. The cumulative incidence of epilepsy at age 10 years was 1.7% (95% CI, 1.4%-2.1%) for patients with pertussis and 0.9% (95% CI, 0.8%-1.0%) for the matched comparison cohort. The corresponding adjusted overall hazard ratio was 1.7 (95% CI, 1.3-2.1).CONCLUSIONS AND RELEVANCE: In Denmark, risk of epilepsy was increased in children with hospital-diagnosed pertussis infections compared with the general population; however, the absolute risk was low.",
keywords = "Morbidity, Long-term, Cohort study, Population based, Pertussis Toxin, epilepsy",
author = "Morten Olsen and Thygesen, {Sandra K} and {\O}stergaard, {John R} and Henrik Nielsen and Henderson, {Victor W} and Vera Ehrenstein and Mette N{\o}rgaard and S{\o}rensen, {Henrik Toft}",
year = "2015",
month = nov,
day = "3",
doi = "10.1001/jama.2015.13971",
language = "English",
volume = "314",
pages = "1844--9",
journal = "JAMA: The Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "17",

}

RIS

TY - JOUR

T1 - Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy

AU - Olsen, Morten

AU - Thygesen, Sandra K

AU - Østergaard, John R

AU - Nielsen, Henrik

AU - Henderson, Victor W

AU - Ehrenstein, Vera

AU - Nørgaard, Mette

AU - Sørensen, Henrik Toft

PY - 2015/11/3

Y1 - 2015/11/3

N2 - IMPORTANCE: Pertussis is associated with encephalopathy and seizures in infants. However, the risk of childhood epilepsy following pertussis is unknown.OBJECTIVE: To examine whether pertussis is associated with the long-term risk of epilepsy.DESIGN, SETTING, AND PARTICIPANTS: We used individually linked data from population-based medical registries covering all Danish hospitals to identify a cohort of all patients with pertussis born between 1978 and 2011, followed up through 2011. We used the Civil Registration System to identify 10 individuals from the general population for each patient with pertussis, matched on sex and year of birth.EXPOSURES: Inpatient or hospital-based outpatient diagnosis of pertussis.MAIN OUTCOMES AND MEASURES: Cumulative incidence and hazard ratio of time to hospital-based epilepsy diagnosis (pertussis cohort vs general population cohort), adjusted for birth year, sex, maternal history of epilepsy, presence of congenital malformations, and gestational age. Unique personal identifiers permitted unambiguous data linkage and complete follow-up for death, emigration, and hospital contacts.RESULTS: We identified 4700 patients with pertussis (48% male), of whom 90 developed epilepsy during the follow-up. The cumulative incidence of epilepsy at age 10 years was 1.7% (95% CI, 1.4%-2.1%) for patients with pertussis and 0.9% (95% CI, 0.8%-1.0%) for the matched comparison cohort. The corresponding adjusted overall hazard ratio was 1.7 (95% CI, 1.3-2.1).CONCLUSIONS AND RELEVANCE: In Denmark, risk of epilepsy was increased in children with hospital-diagnosed pertussis infections compared with the general population; however, the absolute risk was low.

AB - IMPORTANCE: Pertussis is associated with encephalopathy and seizures in infants. However, the risk of childhood epilepsy following pertussis is unknown.OBJECTIVE: To examine whether pertussis is associated with the long-term risk of epilepsy.DESIGN, SETTING, AND PARTICIPANTS: We used individually linked data from population-based medical registries covering all Danish hospitals to identify a cohort of all patients with pertussis born between 1978 and 2011, followed up through 2011. We used the Civil Registration System to identify 10 individuals from the general population for each patient with pertussis, matched on sex and year of birth.EXPOSURES: Inpatient or hospital-based outpatient diagnosis of pertussis.MAIN OUTCOMES AND MEASURES: Cumulative incidence and hazard ratio of time to hospital-based epilepsy diagnosis (pertussis cohort vs general population cohort), adjusted for birth year, sex, maternal history of epilepsy, presence of congenital malformations, and gestational age. Unique personal identifiers permitted unambiguous data linkage and complete follow-up for death, emigration, and hospital contacts.RESULTS: We identified 4700 patients with pertussis (48% male), of whom 90 developed epilepsy during the follow-up. The cumulative incidence of epilepsy at age 10 years was 1.7% (95% CI, 1.4%-2.1%) for patients with pertussis and 0.9% (95% CI, 0.8%-1.0%) for the matched comparison cohort. The corresponding adjusted overall hazard ratio was 1.7 (95% CI, 1.3-2.1).CONCLUSIONS AND RELEVANCE: In Denmark, risk of epilepsy was increased in children with hospital-diagnosed pertussis infections compared with the general population; however, the absolute risk was low.

KW - Morbidity, Long-term

KW - Cohort study

KW - Population based

KW - Pertussis Toxin

KW - epilepsy

U2 - 10.1001/jama.2015.13971

DO - 10.1001/jama.2015.13971

M3 - Journal article

C2 - 26529162

VL - 314

SP - 1844

EP - 1849

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

SN - 0098-7484

IS - 17

ER -