John Rosendahl Østergaard

Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery

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Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery. / Østergaard, John Rosendahl; Mikkelsen, E; Voldby, B.

In: Cephalalgia, Vol. 1, No. 4, 1981, p. 223-8.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Østergaard, JR, Mikkelsen, E & Voldby, B 1981, 'Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery', Cephalalgia, vol. 1, no. 4, pp. 223-8.

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Author

Østergaard, John Rosendahl ; Mikkelsen, E ; Voldby, B. / Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery. In: Cephalalgia. 1981 ; Vol. 1, No. 4. pp. 223-8.

Bibtex

@article{e49c7820edeb11dd8f9a000ea68e967b,
title = "Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery",
abstract = "Isometric tension was recorded in ring preparations of human superficial temporal arteries contracted by noradrenaline (NA), 5-hydroxytryptamine (5-HT), and ergotamine. In contrast to NA and 5-HT, ergotamine induced long-lasting contractions refractive to additional stimulations and resistant to repeated wash-out. When tested against 5-HT, ergotamine acted as a non-competitive antagonist. When repeating the 5-HT stimulations (4.7 x 10(-5) M) the contractile response decreased indicating tachyphylaxis to this agent. As ergotamine revealed both a vasoconstrictive and a 5-HT-blocking activity, the beneficial effect in migraine may be by an interference during both the vasoconstrictory and vasodilatory phases.",
keywords = "Adult, Aged, Dose-Response Relationship, Drug, Ergotamine, Female, Humans, Male, Middle Aged, Migraine Disorders, Muscle Contraction, Muscle, Smooth, Vascular, Norepinephrine, Serotonin, Serotonin Antagonists, Tachyphylaxis, Temporal Arteries, Vasoconstriction",
author = "{\O}stergaard, {John Rosendahl} and E Mikkelsen and B Voldby",
year = "1981",
language = "English",
volume = "1",
pages = "223--8",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "SAGE Publications Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery

AU - Østergaard, John Rosendahl

AU - Mikkelsen, E

AU - Voldby, B

PY - 1981

Y1 - 1981

N2 - Isometric tension was recorded in ring preparations of human superficial temporal arteries contracted by noradrenaline (NA), 5-hydroxytryptamine (5-HT), and ergotamine. In contrast to NA and 5-HT, ergotamine induced long-lasting contractions refractive to additional stimulations and resistant to repeated wash-out. When tested against 5-HT, ergotamine acted as a non-competitive antagonist. When repeating the 5-HT stimulations (4.7 x 10(-5) M) the contractile response decreased indicating tachyphylaxis to this agent. As ergotamine revealed both a vasoconstrictive and a 5-HT-blocking activity, the beneficial effect in migraine may be by an interference during both the vasoconstrictory and vasodilatory phases.

AB - Isometric tension was recorded in ring preparations of human superficial temporal arteries contracted by noradrenaline (NA), 5-hydroxytryptamine (5-HT), and ergotamine. In contrast to NA and 5-HT, ergotamine induced long-lasting contractions refractive to additional stimulations and resistant to repeated wash-out. When tested against 5-HT, ergotamine acted as a non-competitive antagonist. When repeating the 5-HT stimulations (4.7 x 10(-5) M) the contractile response decreased indicating tachyphylaxis to this agent. As ergotamine revealed both a vasoconstrictive and a 5-HT-blocking activity, the beneficial effect in migraine may be by an interference during both the vasoconstrictory and vasodilatory phases.

KW - Adult

KW - Aged

KW - Dose-Response Relationship, Drug

KW - Ergotamine

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Migraine Disorders

KW - Muscle Contraction

KW - Muscle, Smooth, Vascular

KW - Norepinephrine

KW - Serotonin

KW - Serotonin Antagonists

KW - Tachyphylaxis

KW - Temporal Arteries

KW - Vasoconstriction

M3 - Journal article

C2 - 7347625

VL - 1

SP - 223

EP - 228

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 4

ER -