John Rosendahl Østergaard

Educational delay and attainment in persons with neurofibromatosis 1 in Denmark

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Educational delay and attainment in persons with neurofibromatosis 1 in Denmark. / Doser, Karoline; Kenborg, Line; Andersen, Elisabeth Wreford; Bidstrup, Pernille Envold; Kroyer, Anja; Hove, Hanne; Østergaard, John; Sørensen, Sven Asger; Johansen, Christoffer; Mulvihill, John; Winther, Jeanette Falck; Dalton, Susanne Oksbjerg.

In: European Journal of Human Genetics, Vol. 27, 2019, p. 857-868.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Doser, K, Kenborg, L, Andersen, EW, Bidstrup, PE, Kroyer, A, Hove, H, Østergaard, J, Sørensen, SA, Johansen, C, Mulvihill, J, Winther, JF & Dalton, SO 2019, 'Educational delay and attainment in persons with neurofibromatosis 1 in Denmark', European Journal of Human Genetics, vol. 27, pp. 857-868. https://doi.org/10.1038/s41431-019-0359-8

APA

Doser, K., Kenborg, L., Andersen, E. W., Bidstrup, P. E., Kroyer, A., Hove, H., Østergaard, J., Sørensen, S. A., Johansen, C., Mulvihill, J., Winther, J. F., & Dalton, S. O. (2019). Educational delay and attainment in persons with neurofibromatosis 1 in Denmark. European Journal of Human Genetics, 27, 857-868. https://doi.org/10.1038/s41431-019-0359-8

CBE

Doser K, Kenborg L, Andersen EW, Bidstrup PE, Kroyer A, Hove H, Østergaard J, Sørensen SA, Johansen C, Mulvihill J, Winther JF, Dalton SO. 2019. Educational delay and attainment in persons with neurofibromatosis 1 in Denmark. European Journal of Human Genetics. 27:857-868. https://doi.org/10.1038/s41431-019-0359-8

MLA

Vancouver

Doser K, Kenborg L, Andersen EW, Bidstrup PE, Kroyer A, Hove H et al. Educational delay and attainment in persons with neurofibromatosis 1 in Denmark. European Journal of Human Genetics. 2019;27:857-868. https://doi.org/10.1038/s41431-019-0359-8

Author

Doser, Karoline ; Kenborg, Line ; Andersen, Elisabeth Wreford ; Bidstrup, Pernille Envold ; Kroyer, Anja ; Hove, Hanne ; Østergaard, John ; Sørensen, Sven Asger ; Johansen, Christoffer ; Mulvihill, John ; Winther, Jeanette Falck ; Dalton, Susanne Oksbjerg. / Educational delay and attainment in persons with neurofibromatosis 1 in Denmark. In: European Journal of Human Genetics. 2019 ; Vol. 27. pp. 857-868.

Bibtex

@article{e4d5e54ddc924daba9c83047e3a0dc1f,
title = "Educational delay and attainment in persons with neurofibromatosis 1 in Denmark",
abstract = " Most research on psychosocial consequences of neurofibromatosis type 1 (NF1) has focused on the relationship between disease factors and cognitive functioning. NF1 may impair domains of learning and attention, resulting in low academic performance. This study is the first nationwide population-based cohort study to investigate educational attainment and delay in completing mandatory school by persons with NF1. Educational information was collected from 550 persons at the age of 30 (born 1965–1984). They were diagnosed with NF1 in Denmark and compared to a cohort of NF1-free persons matched on gender and age (n = 4295). Multinomial logistic models were applied to estimate odds ratios (ORs) for obtaining short (≤9 years) or medium (10–12 years) education compared to long education (>12 years) by the age of 30 years. We calculated the probability of graduating 9 th year of mandatory school at different ages in 932 persons with NF1 and 7962 NF1-free persons (born 1965–2000) using quantile regression. The OR of educational completion for short- and medium-term education was three fold (95% CI 2.55–3.99) and 1.29 fold (95% CI 0.99–1.69) higher, respectively, for persons with NF1 than NF1-free persons after adjusting for birth year, gender, psychiatric and somatic morbidity and mother{\textquoteright}s education. Persons with NF1 were significantly delayed in graduating mandatory school education compared to NF1-free persons. When 90% of persons have graduated, persons with NF1 were 1.2 times older than the NF1-free persons. Experiencing delays in mandatory school likely affect further educational achievements and may impair employment and entering work force. ",
author = "Karoline Doser and Line Kenborg and Andersen, {Elisabeth Wreford} and Bidstrup, {Pernille Envold} and Anja Kroyer and Hanne Hove and John {\O}stergaard and S{\o}rensen, {Sven Asger} and Christoffer Johansen and John Mulvihill and Winther, {Jeanette Falck} and Dalton, {Susanne Oksbjerg}",
year = "2019",
doi = "10.1038/s41431-019-0359-8",
language = "English",
volume = "27",
pages = "857--868",
journal = "European Journal of Human Genetics",
issn = "1018-4813",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Educational delay and attainment in persons with neurofibromatosis 1 in Denmark

AU - Doser, Karoline

AU - Kenborg, Line

AU - Andersen, Elisabeth Wreford

AU - Bidstrup, Pernille Envold

AU - Kroyer, Anja

AU - Hove, Hanne

AU - Østergaard, John

AU - Sørensen, Sven Asger

AU - Johansen, Christoffer

AU - Mulvihill, John

AU - Winther, Jeanette Falck

AU - Dalton, Susanne Oksbjerg

PY - 2019

Y1 - 2019

N2 - Most research on psychosocial consequences of neurofibromatosis type 1 (NF1) has focused on the relationship between disease factors and cognitive functioning. NF1 may impair domains of learning and attention, resulting in low academic performance. This study is the first nationwide population-based cohort study to investigate educational attainment and delay in completing mandatory school by persons with NF1. Educational information was collected from 550 persons at the age of 30 (born 1965–1984). They were diagnosed with NF1 in Denmark and compared to a cohort of NF1-free persons matched on gender and age (n = 4295). Multinomial logistic models were applied to estimate odds ratios (ORs) for obtaining short (≤9 years) or medium (10–12 years) education compared to long education (>12 years) by the age of 30 years. We calculated the probability of graduating 9 th year of mandatory school at different ages in 932 persons with NF1 and 7962 NF1-free persons (born 1965–2000) using quantile regression. The OR of educational completion for short- and medium-term education was three fold (95% CI 2.55–3.99) and 1.29 fold (95% CI 0.99–1.69) higher, respectively, for persons with NF1 than NF1-free persons after adjusting for birth year, gender, psychiatric and somatic morbidity and mother’s education. Persons with NF1 were significantly delayed in graduating mandatory school education compared to NF1-free persons. When 90% of persons have graduated, persons with NF1 were 1.2 times older than the NF1-free persons. Experiencing delays in mandatory school likely affect further educational achievements and may impair employment and entering work force.

AB - Most research on psychosocial consequences of neurofibromatosis type 1 (NF1) has focused on the relationship between disease factors and cognitive functioning. NF1 may impair domains of learning and attention, resulting in low academic performance. This study is the first nationwide population-based cohort study to investigate educational attainment and delay in completing mandatory school by persons with NF1. Educational information was collected from 550 persons at the age of 30 (born 1965–1984). They were diagnosed with NF1 in Denmark and compared to a cohort of NF1-free persons matched on gender and age (n = 4295). Multinomial logistic models were applied to estimate odds ratios (ORs) for obtaining short (≤9 years) or medium (10–12 years) education compared to long education (>12 years) by the age of 30 years. We calculated the probability of graduating 9 th year of mandatory school at different ages in 932 persons with NF1 and 7962 NF1-free persons (born 1965–2000) using quantile regression. The OR of educational completion for short- and medium-term education was three fold (95% CI 2.55–3.99) and 1.29 fold (95% CI 0.99–1.69) higher, respectively, for persons with NF1 than NF1-free persons after adjusting for birth year, gender, psychiatric and somatic morbidity and mother’s education. Persons with NF1 were significantly delayed in graduating mandatory school education compared to NF1-free persons. When 90% of persons have graduated, persons with NF1 were 1.2 times older than the NF1-free persons. Experiencing delays in mandatory school likely affect further educational achievements and may impair employment and entering work force.

UR - http://www.scopus.com/inward/record.url?scp=85062471295&partnerID=8YFLogxK

U2 - 10.1038/s41431-019-0359-8

DO - 10.1038/s41431-019-0359-8

M3 - Journal article

C2 - 30820037

AN - SCOPUS:85062471295

VL - 27

SP - 857

EP - 868

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

ER -