John Rosendahl Østergaard

Calcium antagonistic effects of terodiline in rabbit aorta and human uterus

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  • The Department of Paediatrics
The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5--36 microM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced 45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.
Original languageEnglish
JournalActa pharmacologica et toxicologica
Volume46 Suppl 1
Pages (from-to)12-9
Number of pages7
ISSN0001-6683
Publication statusPublished - 1980

    Research areas

  • Adult, Animals, Aorta, Thoracic, Butylamines, Calcium, Dose-Response Relationship, Drug, Female, Humans, Male, Muscle, Smooth, Myometrium, Parasympatholytics, Pregnancy, Rabbits, Uterus

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