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John Rosendahl Østergaard

Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT. / Folkestad, Lars; Groth, Kristian A; Shanbhogue, Vikram; Hove, Hanne; Kyhl, Kasper; Østergaard, John R; Jørgensen, Niklas Rye; Andersen, Niels H; Gravholt, Claus H.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 35, No. 12, 12.2020, p. 2335-2344.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Folkestad, L, Groth, KA, Shanbhogue, V, Hove, H, Kyhl, K, Østergaard, JR, Jørgensen, NR, Andersen, NH & Gravholt, CH 2020, 'Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 35, no. 12, pp. 2335-2344. https://doi.org/10.1002/jbmr.4138

APA

Folkestad, L., Groth, K. A., Shanbhogue, V., Hove, H., Kyhl, K., Østergaard, J. R., Jørgensen, N. R., Andersen, N. H., & Gravholt, C. H. (2020). Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(12), 2335-2344. https://doi.org/10.1002/jbmr.4138

CBE

Folkestad L, Groth KA, Shanbhogue V, Hove H, Kyhl K, Østergaard JR, Jørgensen NR, Andersen NH, Gravholt CH. 2020. Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 35(12): 2335-2344. https://doi.org/10.1002/jbmr.4138

MLA

Folkestad, Lars et al. "Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2020, 35(12). 2335-2344. https://doi.org/10.1002/jbmr.4138

Vancouver

Folkestad L, Groth KA, Shanbhogue V, Hove H, Kyhl K, Østergaard JR et al. Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2020 Dec;35(12): 2335-2344. https://doi.org/10.1002/jbmr.4138

Author

Folkestad, Lars ; Groth, Kristian A ; Shanbhogue, Vikram ; Hove, Hanne ; Kyhl, Kasper ; Østergaard, John R ; Jørgensen, Niklas Rye ; Andersen, Niels H ; Gravholt, Claus H. / Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT. In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2020 ; Vol. 35, No. 12. pp. 2335-2344.

Bibtex

@article{3f3d5da4962d4905836330e5e8df0e88,
title = "Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT",
abstract = "Marfan Syndrom (MFS) is a hereditary disorder of connective tissue caused by mutations in the fibrillin-1 gene. Studies have shown that patients with MFS have lower bonemass but little is known about the other constituents of bone strength. We hypothesize that patients with MFS will have larger bone area and compromised cortical microarchitecture in comparison to non-MFS individuals. A total of 74 adult patients with MFS and 145 age and gender matched non-MFS reference individuals (ref.gr) were included in this study. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip and the lumbar spine were performed, and bone turn-over and sex hormones were measured. Patients with MFS had significantly lower areal bone mineral density (BMD) at the total spine (-13%) and total hip (-7%) when compared with the ref.gr. Patients with MFS had significantly larger total bone area at both the radius (+27%) and tibia (+34%). Volumetric BMD at both the measured sites showed significantly reduced total, trabecular and cortical volumetric BMD in patients with MFS compared to the ref.gr. The microarchitectural parameters at the radius and tibia were compromised in patients with MFS with significantly reduced trabecular number and thickness leading to a higher trabecular separation and significantly reduced cortical thickness and increased cortical porosity compared to the reference group. The differences in bone-density, -geometry or -microarchitecture was not explained by increased bone turnover markers or circulating levels of sex hormones. We conclude patients with MFS had altered bone geometry, altered bone microstructure and lower bone mass (lower aBMD and vBMD at all sites) compared to healthy reference individuals. Future studies should focus on fracture rates and fracture risk in adult and aging patients with MFS.",
author = "Lars Folkestad and Groth, {Kristian A} and Vikram Shanbhogue and Hanne Hove and Kasper Kyhl and {\O}stergaard, {John R} and J{\o}rgensen, {Niklas Rye} and Andersen, {Niels H} and Gravholt, {Claus H}",
note = "This article is protected by copyright. All rights reserved.",
year = "2020",
month = dec,
doi = "10.1002/jbmr.4138",
language = "English",
volume = "35",
pages = " 2335--2344",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT

AU - Folkestad, Lars

AU - Groth, Kristian A

AU - Shanbhogue, Vikram

AU - Hove, Hanne

AU - Kyhl, Kasper

AU - Østergaard, John R

AU - Jørgensen, Niklas Rye

AU - Andersen, Niels H

AU - Gravholt, Claus H

N1 - This article is protected by copyright. All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Marfan Syndrom (MFS) is a hereditary disorder of connective tissue caused by mutations in the fibrillin-1 gene. Studies have shown that patients with MFS have lower bonemass but little is known about the other constituents of bone strength. We hypothesize that patients with MFS will have larger bone area and compromised cortical microarchitecture in comparison to non-MFS individuals. A total of 74 adult patients with MFS and 145 age and gender matched non-MFS reference individuals (ref.gr) were included in this study. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip and the lumbar spine were performed, and bone turn-over and sex hormones were measured. Patients with MFS had significantly lower areal bone mineral density (BMD) at the total spine (-13%) and total hip (-7%) when compared with the ref.gr. Patients with MFS had significantly larger total bone area at both the radius (+27%) and tibia (+34%). Volumetric BMD at both the measured sites showed significantly reduced total, trabecular and cortical volumetric BMD in patients with MFS compared to the ref.gr. The microarchitectural parameters at the radius and tibia were compromised in patients with MFS with significantly reduced trabecular number and thickness leading to a higher trabecular separation and significantly reduced cortical thickness and increased cortical porosity compared to the reference group. The differences in bone-density, -geometry or -microarchitecture was not explained by increased bone turnover markers or circulating levels of sex hormones. We conclude patients with MFS had altered bone geometry, altered bone microstructure and lower bone mass (lower aBMD and vBMD at all sites) compared to healthy reference individuals. Future studies should focus on fracture rates and fracture risk in adult and aging patients with MFS.

AB - Marfan Syndrom (MFS) is a hereditary disorder of connective tissue caused by mutations in the fibrillin-1 gene. Studies have shown that patients with MFS have lower bonemass but little is known about the other constituents of bone strength. We hypothesize that patients with MFS will have larger bone area and compromised cortical microarchitecture in comparison to non-MFS individuals. A total of 74 adult patients with MFS and 145 age and gender matched non-MFS reference individuals (ref.gr) were included in this study. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip and the lumbar spine were performed, and bone turn-over and sex hormones were measured. Patients with MFS had significantly lower areal bone mineral density (BMD) at the total spine (-13%) and total hip (-7%) when compared with the ref.gr. Patients with MFS had significantly larger total bone area at both the radius (+27%) and tibia (+34%). Volumetric BMD at both the measured sites showed significantly reduced total, trabecular and cortical volumetric BMD in patients with MFS compared to the ref.gr. The microarchitectural parameters at the radius and tibia were compromised in patients with MFS with significantly reduced trabecular number and thickness leading to a higher trabecular separation and significantly reduced cortical thickness and increased cortical porosity compared to the reference group. The differences in bone-density, -geometry or -microarchitecture was not explained by increased bone turnover markers or circulating levels of sex hormones. We conclude patients with MFS had altered bone geometry, altered bone microstructure and lower bone mass (lower aBMD and vBMD at all sites) compared to healthy reference individuals. Future studies should focus on fracture rates and fracture risk in adult and aging patients with MFS.

U2 - 10.1002/jbmr.4138

DO - 10.1002/jbmr.4138

M3 - Journal article

C2 - 32706399

VL - 35

SP - 2335

EP - 2344

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 12

ER -