John Rosendahl Østergaard

Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement

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Anxiety and depression in Klinefelter syndrome : The impact of personality and social engagement. / Skakkebæk, Anne; Moore, Philip J; Pedersen, Anders Degn; Bojesen, Anders; Kristensen, Maria Krarup; Fedder, Jens; Hertz, Jens Michael; Østergaard, John R; Wallentin, Mikkel; Gravholt, Claus Højbjerg.

In: PLOS ONE, Vol. 13, No. 11, e0206932, 2018.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Skakkebæk, Anne ; Moore, Philip J ; Pedersen, Anders Degn ; Bojesen, Anders ; Kristensen, Maria Krarup ; Fedder, Jens ; Hertz, Jens Michael ; Østergaard, John R ; Wallentin, Mikkel ; Gravholt, Claus Højbjerg. / Anxiety and depression in Klinefelter syndrome : The impact of personality and social engagement. In: PLOS ONE. 2018 ; Vol. 13, No. 11.

Bibtex

@article{6b6ce56d30db4a5e9d4a9e3702d36786,
title = "Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement",
abstract = "Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.",
author = "Anne Skakkeb{\ae}k and Moore, {Philip J} and Pedersen, {Anders Degn} and Anders Bojesen and Kristensen, {Maria Krarup} and Jens Fedder and Hertz, {Jens Michael} and {\O}stergaard, {John R} and Mikkel Wallentin and Gravholt, {Claus H{\o}jbjerg}",
year = "2018",
doi = "10.1371/journal.pone.0206932",
language = "English",
volume = "13",
journal = "P L o S One",
issn = "1932-6203",
publisher = "public library of science",
number = "11",

}

RIS

TY - JOUR

T1 - Anxiety and depression in Klinefelter syndrome

T2 - The impact of personality and social engagement

AU - Skakkebæk, Anne

AU - Moore, Philip J

AU - Pedersen, Anders Degn

AU - Bojesen, Anders

AU - Kristensen, Maria Krarup

AU - Fedder, Jens

AU - Hertz, Jens Michael

AU - Østergaard, John R

AU - Wallentin, Mikkel

AU - Gravholt, Claus Højbjerg

PY - 2018

Y1 - 2018

N2 - Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.

AB - Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.

U2 - 10.1371/journal.pone.0206932

DO - 10.1371/journal.pone.0206932

M3 - Journal article

C2 - 30412595

VL - 13

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 11

M1 - e0206932

ER -