Aarhus University Seal / Aarhus Universitets segl

Jørgen Kjems

Professor

Research outputs

Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial

Godskesen, L. E., Lassen, T. R., Jespersen, N. R., Siersbæk, M., Yan, Y., Nielsen, M. M., Tjønnfjord, S. K., Grøntved, L., Madsen, G., Kjems, J., Bøtker, H. E., Schmidt, M. R., Krag, A. & Kjeldsen, J., 1 Dec 2020, In: Scientific Reports. 10, 1, 15 p., 9537.

A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma

Das Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B., Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E., Kristensen, L. S. & Pivarcsi, A., Dec 2020, In: Scientific Reports. 10, 3637.

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Hait, A. S., Olagnier, D., Sancho-Shimizu, V., Skipper, K. A., Helleberg, M., Larsen, S. M., Bodda, C., Moldovan, L. I., Ren, F., Brinck Andersen, N-S., Thomsen, M. M., Freytag, M. R., Darmalinggam, S., Parkes, I., Kadekar, D. D., Rahbek, S. H., van der Horst, D., Kristensen, L. S., Eriksson, K., Kjems, J., Mostowy, S., Christiansen, M., Mikkelsen, J. G., Brandt, C. T., Paludan, S. R. & Mogensen, T. H., Dec 2020, In: Science Immunology. 5, 54, 17 p., eabc2691.

Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J. & Kjems, J., Dec 2020, In: Molecular Therapy - Nucleic Acids. 22, p. 994-1003 10 p.

Linking the association between circRNAs and Alzheimer's disease progression by multi-tissue circular RNA characterization

Lo, IJ., Hill, J., Vilhjálmsson, B. J. & Kjems, J., Dec 2020, In: RNA Biology. 17, 12, p. 1789-1797 9 p.

Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory

Kristensen, L. S., Ebbesen, K. K., Sokol, M., Jakobsen, T., Korsgaard, U., Eriksen, A. C., Hansen, T. B., Kjems, J. & Hager, H., Dec 2020, In: Nature Communications. 11, 4551.

A circular RNA generated from an intron of the insulin gene controls insulin secretion

Stoll, L., Rodríguez-Trejo, A., Guay, C., Brozzi, F., Bayazit, M. B., Gattesco, S., Menoud, V., Sobel, J., Marques, A. C., Venø, M. T., Esguerra, J. L. S., Barghouth, M., Suleiman, M., Marselli, L., Kjems, J., Eliasson, L., Renström, E., Bouzakri, K., Pinget, M., Marchetti, P. & Regazzi, R., Nov 2020, In: Nature Communications. 11, 5611.

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., Knoblich, J. A., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J. C., Marioni, J. C., Marti-Renom, M. A., Netea, M. G., Nickel, D., Nollmann, M., Novak, H. R., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J. L., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F. J., Torres-Padilla, M. E., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M., Voet, T. & LifeTime Community Working Groups, Nov 2020, In: Nature. 587, p. 377-386 10 p.

Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles

Moldovan, L. I., Tsoi, L. C., Ranjitha, U., Hager, H., Weidinger, S., Gudjonsson, J. E., Kjems, J. & Kristensen, L. S., 28 Oct 2020, In: Experimental Dermatology.

Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin

Gonçalves, N. P., Yan, Y., Ulrichsen, M., Venø, M. T., Poulsen, E. T., Enghild, J. J., Kjems, J. & Vægter, C. B., Oct 2020, In: Biomedicines. 8, 11, 24 p., 450.

Comprehensive analysis of soluble RNAs in human embryo culture media and blastocoel fluid

Kirkegaard, K., Yan, Y., Sørensen, B. S., Hardason, T., Hanson, C., Ingerslev, H. J., Knudsen, U. B., Kjems, J., Lundin, K. & Ahlström, A., Sep 2020, In: Journal of Assisted Reproduction and Genetics. 37, 9, p. 2199–2209 11 p.

Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs)

Yan, Y., Chang, C., Su, J., Venø, M. T. & Kjems, J., Sep 2020, In: Biomedicines. 8, 10, 17 p., 387.

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Venø, M. T., Reschke, C. R., Morris, G., Connolly, N. M. C., Su, J., Yan, Y., Engel, T., Jimenez-Mateos, E. M., Harder, L. M., Pultz, D., Haunsberger, S. J., Pal, A., Heller, J. P., Campbell, A., Langa, E., Brennan, G. P., Conboy, K., Richardson, A., Norwood, B. A., Costard, L. S., Neubert, V., Gallo, F. D., Salvetti, B., Vangoor, V. R., Sanz-Rodriguez, A., Muilu, J., Fabene, P. F., Pasterkamp, R. J., Prehn, J. H. M., Schorge, S., Andersen, J. S., Rosenow, F., Bauer, S., Kjems, J. & Henshall, D. C., Jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15977-15988 12 p.

Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats

Yoshimoto, R., Rahimi, K., Hansen, T. B., Kjems, J. & Mayeda, A., Jul 2020, In: iScience. 23, 7, 101345.

Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling

Mortensen, M. R., Skovsgaard, M. B., Märcher, A., Andersen, V. L., Palmfeldt, J., Nielsen, T. B., Tørring, T., Laursen, N. S., Andersen, K. R., Kjems, J. & Gothelf, K. V., May 2020, In: Bioconjugate Chemistry. 31, 5, p. 1295-1300 6 p.

Automated One-Double-Z Pair BaseScope™ for CircRNA In Situ Hybridization

Nielsen, B. S., Møller, T. & Kjems, J., 2020, In Situ Hybridization Protocols. Schnack Nielsen, B. & Jones, J. (eds.). New York: Humana Press, Inc., p. 379-388 10 p. (Methods in Molecular Biology, Vol. 2148).

Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models

Ramsay, E., Raviña, M., Sarkhel, S., Hehir, S., Cameron, N. R., Ilmarinen, T., Skottman, H., Kjems, J., Urtti, A., Ruponen, M. & Subrizi, A., 2020, In: Pharmaceutics. 12, 7, 17 p., 667.

Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles

Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., Jørgensen, M. M., Kjems, J., Vissing, K. & Drasbek, K. R., 2020, In: Scientific Reports. 10, 1, 13 p., 5835.

A large size-selective DNA nanopore with sensing applications

Thomsen, R. P., Malle, M. G., Okholm, A. H., Krishnan, S., Bohr, S. S. R., Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, N. S. & Kjems, J., Dec 2019, In: Nature Communications. 10, 1, 5655.

Imaging rheumatoid arthritis in mice using combined near infrared and 19F magnetic resonance modalities

Vu-Quang, H., Vinding, M. S., Jakobsen, M., Song, P., Dagnaes-Hansen, F., Nielsen, N. C. & Kjems, J., Dec 2019, In: Scientific Reports. 9, 14314.

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Moldovan, L-I., Hansen, T. B., Venø, M. T., Okholm, T. L. H., Andersen, T. L., Hager, H., Iversen, L., Kjems, J., Johansen, C. & Kristensen, L. S., 27 Nov 2019, In: BMC Medical Genomics. 12, 1, 174.

The Role of Nanoscale Distribution of Fibronectin in Staphylococcus aureus Adhesion to Interfaces and the Multivalency in Fn-FBPs interaction utilizing the DNA-PAINT.

Khateb, H., Sørensen, R. S., Rikke Louise Meyer, Kjems, J. & Sutherland, D. S., 14 Nov 2019, (In preparation) 25 p.

The biogenesis, biology and characterization of circular RNAs

Kristensen, L. S., Schertz Andersen, M., Stagsted, L. V. W., Ebbesen, K., Hansen, T. B. & Kjems, J., Nov 2019, In: Nature Reviews. Genetics. 20, 11, p. 675-691 17 p.

Delivering antibiotics locally to biofilms by targeted drug delivery and prodrug therapy

Meyer, R. L., Walther, R., Nielsen, S. M., Andersen, P. O., Hansen, L., Vu-Quang, H., Kjems, J. & Zelikin, A. N., 3 Sep 2019.

SMARTer single cell total RNA sequencing

Verboom, K., Everaert, C., Bolduc, N., Livak, K. J., Yigit, N., Rombaut, D., Anckaert, J., Lee, S., Venø, M. T., Kjems, J., Speleman, F., Mestdagh, P. & Vandesompele, J., Sep 2019, In: Nucleic Acids Research. 47, 16, 12 p., e93.

Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM

Nielsen, T. B., Thomsen, R. P., Mortensen, M. R., Kjems, J., Nielsen, P. F., Nielsen, T. E., Kodal, A. L. B., Cló, E. & Gothelf, K. V., Jul 2019, In: Angewandte Chemie International Edition. 58, 27, p. 9068-9072 5 p.

Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries

Raniolo, S., Croce, S., Thomsen, R. P., Okholm, A. H., Unida, V., Iacovelli, F., Manetto, A., Kjems, J., Desideri, A. & Biocca, S., Jun 2019, In: Nanoscale. 11, 22, p. 10808-10818 11 p.

Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant

Krissanaprasit, A., Key, C., Fergione, M., Froehlich, K., Pontula, S., Hart, M., Carriel, P., Kjems, J., Andersen, E. S. & LaBean, T. H., May 2019, In: Advanced Materials. 31, 21, 7 p., 1808262.

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., Apr 2019, In: Theranostics. 9, 9, p. 2662-2677

Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging

Vu-Quang, H., Vinding, M. S., Nielsen, T., Ullisch, M. G., Nielsen, N. C., Nguyen, D. T. & Kjems, J., Apr 2019, In: Polymers. 11, 4, 743.

Selective delivery of doxorubicin to EGFR+ cancer cells by Cetuximab‐DNA conjugates

Liu, T., Song, P., Märcher, A., Kjems, J., Yang, C. & Gothelf, K. V., Apr 2019, In: ChemBioChem. 20, 8, p. 1014-1018 5 p.

An RNA origami octahedron with intrinsic siRNAs for potent gene knockdown

Høiberg, H. C., Sparvath, S. M., Andersen, V. L., Kjems, J. & Andersen, E. S., Jan 2019, In: Biotechnology Journal. 14, 1, 1700634.

Strontium functionalized scaffold for bone tissue engineering

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M., Jan 2019, In: Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems. 94, p. 509-515 7 p.

Aptamer-targeted drug delivery for Staphylococcus aureus biofilm infections

Andersen, P. O., Hansen, L., Hansen, B. K., Vu Quang, H., Kjems, J. & Meyer, R. L., 2019, (In preparation) In: Nanomedicine: Nanotechnology, Biology and Medicine.

Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression

Costard, L. S., Neubert, V., Venø, M. T., Su, J., Kjems, J., Connolly, N. M. C., Prehn, J. H. M., Schratt, G., Henshall, D. C., Rosenow, F. & Bauer, S., 2019, In: Brain Stimulation. 12, 6, p. 1390-1401 12 p.

Isolating, Sequencing and Analyzing Extracellular MicroRNAs from Human Mesenchymal Stem Cells

Yan, Y., Chang, C. C., Venø, M. T., Mothershead, C. R., Su, J. & Kjems, J., 2019, In: Journal of visualized experiments : JoVE. 145, 13 p., e58655.

Lipidoid-siRNA Nanoparticle-Mediated IL-1 beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model

Song, P., Yang, C., Thomsen, J. S., Dagnaes-Hansen, F., Jakobsen, M., Bruel, A., Deleuran, B. & Kjems, J., 2019, In: Molecular Therapy. 27, 8, p. 1424-1435 12 p.

Single molecule analysis of structural fluctuations in DNA nanostructures

Jepsen, M. D. E., Sørensen, R. S., Maffeo, C., Aksimentiev, A., Kjems, J. & Birkedal, V., 2019, In: Nanoscale. 11, 39, p. 18475-18482 8 p.

Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs

Hollensen, A. K., Andersen, S., Hjorth, K., Bak, R. O., Hansen, T. B., Kjems, J., Aagaard, L., Damgaard, C. K. & Mikkelsen, J. G., 7 Dec 2018, In: Molecular Therapy - Nucleic Acids. 13, p. 365-375 11 p.

Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins

Mortensen, M. R., Skovsgaard, M. B., Okholm, A. H., Scavenius, C., Dupont, D. M., Rosen, C. B., Enghild, J. J., Kjems, J. & Gothelf, K. V., 19 Sep 2018, In: Bioconjugate Chemistry. 29, 9, p. 3016–3025

Development of an iron oxide nanoparticle drug delivery system against Staphylococcus aureus biofilm infections

Dreier, C., Zelikin, A. N., Kjems, J. & Meyer, R. L., Sep 2018.

Lipidoid-siRNA formulations promote gene silencing in differentiated and nondividing ARPE-19, primary porcine and human embryonic stem cell-derived retinal pigment epithelial cells

Subrizi, A., Yang, C., Ilmarinen, T., Skottman, H., Urtti, A. & Kjems, J., Jul 2018. 2 p.

Theranostic Niosomes for Efficient siRNA/microRNA Delivery and Activatable Near-Infrared Fluorescent Tracking of Stem Cells

Yang, C., Gao, S., Song, P., Dagnæs-Hansen, F., Jakobsen, M. V. & Kjems, J., 13 Jun 2018, In: A C S Applied Materials and Interfaces. 10, 23, p. 19494–19503 10 p.

A modified monomeric red fluorescent protein reporter for assessing CRISPR activity

Knudsen, C. H., ásgrímsdóttir, E. S., Rahimi, K., Gill, K. P., Frandsen, S., Buchholdt, S. H., Chen, M., Kjems, J., Febbraro, F. & Denham, M., 15 May 2018, In: Frontiers in Cell and Developmental Biology. 6, MAY, 10 p., 54.

Calcium-microRNA Complexes Functionalized Nanotubular Implant Surface for Highly Efficient Transfection and Enhanced Osteogenesis of Mesenchymal Stem Cells

Song, W., Yang, C., Svend Le, D. Q., Zhang, Y. & Kjems, J., 7 Mar 2018, In: A C S Applied Materials and Interfaces. 10, 9, p. 7756-7764 9 p.

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

Stoll, L., Sobel, J., Rodriguez-Trejo, A., Guay, C., Lee, K., Venø, M. T., Kjems, J., Laybutt, D. R. & Regazzi, R., 1 Mar 2018, In: Molecular Metabolism. 9, p. 69-83 15 p.

Bioactive Nano-fibrous Scaffold for Vascularized Craniofacial Bone Regeneration

Prabha, R. D., Kraft, D. C. E., Harkness, L., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M., Mar 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12, 3, p. e1537-e1548 12 p.

Global MicroRNA Profiling in Human Bone Marrow Skeletal—Stromal or Mesenchymal–Stem Cells Identified Candidates for Bone Regeneration

Chang, C. C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M. & Kjems, J., 7 Feb 2018, In: Molecular Therapy. 26, 2, p. 593-605 13 p.

Circular RNAs in cancer: opportunities and challenges in the field

Kristensen, L. S., Hansen, T. B., Venø, M. T. & Kjems, J., 1 Feb 2018, In: Oncogene. 37, p. 555–565

Novel Brassinosteroid-Modified Polyethylene Glycol Micelles for Controlled Release of Agrochemicals

Pérez Quiñones, J., Brüggemann, O., Kjems, J., Shahavi, M. H. & Peniche Covas, C., 29 Jan 2018, In: Journal of Agricultural and Food Chemistry. 66, 7, p. 1612-1619 8 p.

Antibacterial isoeugenol coating on stainless steel and polyethylene surfaces prevents biofilm growth

Nielsen, C. K., Subbiahdoss, G., Zeng, G., Salmi, Z., Kjems, J., Mygind, T., Snabe, T. & Meyer, R. L., Jan 2018, In: Journal of Applied Microbiology. 124, 1, p. 179-187 9 p.

Caveolae-mediated mesenchymal stem cell labelling by PSS-coated PLGA PFOB nano-contrast agent for MRI

Vu Quang, H., Chang, C-C. C., Song, P., Hauge, E. M. & Kjems, J., 2018, In: Theranostics. 8, 10, p. 2657-2671

Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation

Kristensen, L. S., Okholm, T. L. H., Venø, M. T. & Kjems, J., 2018, In: RNA Biology. 15, 2, p. 1-12 12 p.

Dihydropyridine fluorophores allow for specific detection of human antibodies in serum

Domaljanovic, I., Rexen Ulven, E., Ulven, T., Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 2018, In: ACS Omega. 3, 7, p. 7580–7586 7 p.

Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies

Dahl, M., Daugaard, I., Andersen, M. S., Hansen, T. B., Grønbæk, K., Kjems, J. & Kristensen, L. S., 2018, In: Laboratory Investigation. 98, p. 1657–1669

Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer

Okholm, T. L. H., Nielsen, M. M., Hamilton, M., Christensen, L-L., Vang, S., Hedegaard, J., Hansen, T. B., Kjems, J., Dyrskjøt, L. & Pedersen, J. S., 28 Nov 2017, In: npj Genomic Medicine. 2, 36.

Theranostic poly(lactic-co-glycolic acid) nanoparticle for magnetic resonance/infrared fluorescence bimodal imaging and efficient siRNA delivery to macrophages and its evaluation in a kidney injury model

Yang, C., Vu Quang, H., Husum, D. M. U., Tingskov, S. J. H., Vinding, M. S., Nielsen, T., Song, P., Nielsen, N. C., Nørregaard, R. & Kjems, J., Nov 2017, In: Nanomedicine: Nanotechnology, Biology and Medicine. 13, 8, p. 2451–2462

Control of enzyme reactions by a reconfigurable DNA nanovault

Grossi, G., Jepsen, M. D. E., Kjems, J. & Andersen, E. S., 19 Oct 2017, In: Nature Communications. 8, 8 p., 992.

A DNA-programmed liposome fusion cascade

Löffler, P. M. G., Ries, O., Rabe, A., Okholm, A. H., Thomsen, R. P., Kjems, J. & Vogel, S., 16 Oct 2017, In: Angewandte Chemie International Edition. 56, 43, p. 13228–13231

The invasion of circRNAs

Hansen, T. B. & Kjems, J., 6 Oct 2017, In: RNA Biology. 14, 8, p. 973-974 2 p.

Construction of a Polyhedral DNA 12-Arm Junction for Self-Assembly of Wireframe DNA Lattices

Manuguerra, I., Grossi, G., Thomsen, R. P., Lyngsø, J., Pedersen, J. S., Kjems, J., Andersen, E. S. & Gothelf, K. V., 26 Sep 2017, In: A C S Nano. 11, 9, p. 9041-9047 7 p.

microRNA sponging by a new hearty circRNA

Ebbesen, K. & Kjems, J., 18 Sep 2017, In: Non-coding RNA Investigation.

New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods

Mulberg, M. W., Taskova, M., Thomsen, R. P., Okholm, A. H., Kjems, J. & Astakhova, K., 17 Aug 2017, In: ChemBioChem. 18, 16, p. 1599-1603 5 p.

Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis

Greisen, S. R., Yan, Y., Hansen, A. S., Veno, M. T., Nyengaard, J. R., Moestrup, S. K., Hvid, M., Freeman, G. J., Kjems, J. & Deleuran, B., 24 Jul 2017, In: Frontiers in Immunology. 8, 14 p., 851.

Fatty acid-modified gapmer antisense oligonucleotide and human serum albumin constructs for pharmacokinetic modulation

Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J., Wengel, J., Kjems, J. & Howard, K., 5 Jul 2017, In: Molecular Therapy. 25, 7, p. 1710-1717

A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses

Rajman, M., Metge, F., Fiore, R., Khudayberdiev, S., Aksoy-Aksel, A., Bicker, S., Reschke, C. R., Raoof, R., Brennan, G. P., Delanty, N., Farrell, M. A., O'Brien, D. F., Bauer, S., Norwood, B., Veno, M. T., Krueger, M., Braun, T., Kjems, J., Rosenow, F., Henshall, D. C., Dieterich, C. & Schratt, G., 14 Jun 2017, In: E M B O Journal. 36, 12, p. 1770-1787 18 p.

Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies

Domljanovic, I., Carstens, A., Okholm, A., Kjems, J., Nielsen, C. T., Heegaard, N. H. H. & Astakhova, K., 15 May 2017, In: Scientific Reports. 7, 9 p., 1925.

Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan/siRNA Nanoparticles in Vitro and in Vivo

Yang, C., Gao, S., Dagnæs-Hansen, F., Jakobsen, M. & Kjems, J., 12 Apr 2017, In: A C S Applied Materials and Interfaces. 9, 14, p. 12203-12216

Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204

Veno, M. T., Veno, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J., 9 Feb 2017, In: Frontiers in Molecular Neuroscience. 10, 31, 10 p., 31.

Antimicrobial effect of emulsion-encapsulated isoeugenol against biofilms of food pathogens and spoilage bacteria

Nielsen, C. K., Kjems, J., Mygind, T., Snabe, T., Schwarz, K., Serfert, Y. & Meyer, R. L., 2 Feb 2017, In: International Journal of Food Microbiology. 242, p. 7–12

Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients

Yan, Y., Wang, X., Venø, M. T., Bakholdt, V., Sørensen, J. A., Krogdahl, A., Sun, Z., Gao, S. & Kjems, J., 31 Jan 2017, In: OncoTarget. 8, 5

RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis

Mooney, C. M., Jimenez-Mateos, E. M., Engel, T., Mooney, C., Diviney, M., Venø, M. T., Kjems, J., Farrell, M. A., O'Brien, D. F., Delanty, N. & Henshall, D. C., 27 Jan 2017, In: Scientific Reports. 7, 14 p., 41517.

Insights into circular RNA biology

Ebbesen, K. K., Hansen, T. B. & Kjems, J., 20 Jan 2017, In: RNA Biology. 14, 8, p. 1035-1045 11 p.

Amplification-free liquid biopsy by fluorescence approach

Uhd, J., Okholm, A., Kjems, J. & Astakhova, K., 1 Jan 2017, Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017. TechConnect, Vol. 3. p. 106-109 4 p.

Novel fluorescent nanoparticles for ultrasensitive identification of nucleic acids by optical methods

Mulberg, M. W., Taskova, M., Thomsen, R. P., Okholm, A. H., Kjems, J. & Astakhova, K., 1 Jan 2017, Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017. TechConnect, Vol. 3. p. 118-121 4 p.

A Targeting Agent For Drug Delivery To Staphylococcus Aureus Biofilms

Andersen, P. O., Hansen, L., Vu Quang, H., Kjems, J. & Meyer, R. L., 2017, p. 198.

Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging

Fay, F., Hansen, L., Hectors, S. J. C. G., Sanchez-Gaytan, B. L., Zhao, Y., Tang, B-J., Munitz, J., Alaarg, A., Braza, M. S., Gianella, A., Aaronson, S. A., Reiner, T., Kjems, J., Langer, R., Hoeben, F. J. M., Janssen, H. M., Calcagno, C., Strijkers, G. J., Fayad, Z. A., Perez-Medina, C. & Mulder, W. J. M., 2017, In: Bioconjugate Chemistry. 28, 5, p. 1413-1421 9 p.

Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma

Daugaard, I., Venø, M. T., Yan, Y., Kjeldsen, T. E., Lamy, P., Hager, H., Kjems, J. & Hansen, L. L., 2017, In: OncoTarget. 8, 16, p. 27047-27061 15 p.

The emerging landscape of circular RNA in life processes

Qu, S., Zhong, Y., Shang, R., Zhang, X., Song, W., Kjems, J. & Li, H., 2017, In: RNA Biology. 14, 8, p. 992-999 8 p.

The utility of DNA nanostructures for drug delivery in vivo

Okholm, A. H. & Kjems, J., 2017, In: Expert Opinion on Drug Delivery. 14, 2, p. 137-139 3 p.

MicroRNAs in epilepsy: pathophysiology and clinical utility

Henshall, D. C., Hamer, H. M., Pasterkamp, R. J., Goldstein, D. B., Kjems, J., Prehn, J. H. M., Schorge, S., Lamottke, K. & Rosenow, F., Dec 2016, In: Lancet Neurology. 15, 13, p. 1368-1376 9 p.

Effects of Tween 80 on Growth and Biofilm Formation in Laboratory Media

Nielsen, C. K., Kjems, J., Mygind, T., Snabe, T. & Meyer, R. L., 22 Nov 2016, In: Frontiers in Microbiology. 7, 10 p., 1878.

DNA nanovehicles and the biological barriers

Okholm, A. H. & Kjems, J., 15 Nov 2016, In: Advanced Drug Delivery Reviews. 106, Part A, p. 183-191 9 p., 16.

Theranostic Tumor Targeted Nanoparticles Combining Drug Delivery with Dual Near Infrared and (19)F Magnetic Resonance Imaging Modalities

Vu-Quang, H., Vinding, M. S., Nielsen, T., Ullisch, M. G., Nielsen, N. C. & Kjems, J., Oct 2016, In: Nanomedicine: Nanotechnology, Biology and Medicine. 12, 7, p. 1873-1884

Interfacing DNA nanodevices with biology: Challenges, solutions and perspectives

Vinther, M. & Kjems, J., 9 Aug 2016, In: New Journal of Physics. 18, 9 p.

In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

Sun, M., Chen, M., Wang, M., Hansen, J., Baatrup, A., Dagnæs-Hansen, F., Rölfing, J. D., Jensen, J., Lysdahl, H., Li, H., Johannsen, M., Le, D. Q. S., Kjems, J. & Bünger, C., 8 Aug 2016, In: RSC Advances. 6, p. 76237-76245 9 p.

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J., 28 Jul 2016, In: Nature Communications. 7, 12294.

Enhancing the antibacterial efficacy of isoeugenol by emulsion encapsulation

Nielsen, C. K., Kjems, J., Mygind, T., Snabe, T., Schwarz, K., Serfert, Y. & Meyer, R. L., 16 Jul 2016, In: International Journal of Food Microbiology. 229, p. 7-14

Intracellular Delivery of a Planar DNA Origami Structure by the Transferrin-Receptor Internalization Pathway

Schaffert, D. H., Okholm, A. H., Sørensen, R. S., Nielsen, J., Tørring, T., Rosen, C. B., Kodal, A. L. B., Mortensen, M. R., Gothelf, K. V. & Kjems, J., 18 May 2016, In: Small. 12, 19, p. 2634-2640

Chitosan polyplex mediated delivery of miRNA-124 reduces activation of microglial cells in vitro and in rat models of spinal cord injury

Louw, A. M., Kolar, M. K., Novikova, L. N., Kingham, P. J., Wiberg, M., Kjems, J. & Novikov, L. N., Apr 2016, In: Nanomedicine: Nanotechnology, Biology and Medicine. 12, 3, p. 643-653 11 p.

Chitosan-coated Poly(lactic-co-glycolic acid) Perfluorooctyl Bromide Nanoparticles for Cell Labeling in 19F Magnetic Resonance Imaging

Vu Quang, H., Vinding, M. S., Xia, D., Nielsen, T., Ullisch, M. G., Dong, M., Nielsen, N. C. & Kjems, J., 20 Jan 2016, In: Carbohydrate Polymers. 136, p. 936-944

A targeting ligand for drug delivery to Staphylococcus aureus biofilms

Andersen, P. O., Kring Hansen, B., Nielsen, J., Hansen, L., Kjems, J. & Meyer, R. L., 2016.

Aptamers as possible targeting agents for delivery of antibiotics to S. aureus biofilms

Andersen, P. O., Hansen, B. K., Hansen, L., Nielsen, J., Kjems, J. & Meyer, R. L., 2016.

Argonaute-associated short introns are a novel class of gene regulators

Hansen, T. B., Venø, M. T., Jensen, T. I., Schaefer, A., Damgaard, C. K. & Kjems, J., 2016, In: Nature Communications. 7, 10 p., 11538.

Circular RNAs: Identification, biogenesis and function

Ebbesen, K. K., Kjems, J. & Hansen, T. B., 2016, In: BBA General Subjects. 1859, 1, p. 163-168 6 p.

MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock

Svenningsen, K., Venø, M. T., Henningsen, K., Mallien, A. S., Jensen, L., Christensen, T., Kjems, J., Vollmayr, B. & Wiborg, O., 2016, In: PLOS ONE. 11, 8, 15 p., e0160318.

Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours

Martirosyan, A., Olesen, M. J., Fenton, R. A., Kjems, J. & Howard, K. A., 2016, In: Nanoscale.

Comparison of circular RNA prediction tools

Hansen, T. B., Venø, M. T., Damgaard, C. K. & Kjems, J., 10 Dec 2015, In: Nucleic Acids Research.

Characterisation of aptamer-target interactions by branched selection and high-throughput sequencing of SELEX pools

Dupont, D. M., Larsen, N., Jensen, J. K., Andreasen, P. A. & Kjems, J., 2 Dec 2015, In: Nucleic Acids Research. 43, 21, p. 1-13 13 p., e139.

Full-length RNA structure prediction of the HIV-1 genome reveals a conserved core domain

Sukosd, Z., Andersen, E. S., Seemann, S. E., Jensen, M., Hansen, M. B., Gorodkin, J. & Kjems, J., 2 Dec 2015, In: Nucleic Acids Research. 43, 21, p. 10168-10179 12 p.

Co-delivery of siRNA and doxorubicin to cancer cells from additively manufactured implants

Chen, M., Andersen, M. Ø., Dillschneider, P., Chang, C-C. C., Gao, S., Le, D. Q. S., Yang, C., Hein, S., Bünger, C. & Kjems, J., 16 Nov 2015, In: RSC Advances. 5, p. 101718-101725 8 p.

Theranostic carbon dots derived from garlic with efficient anti-oxidative effects towards macrophages

Yang, C., Ogaki, R., Hansen, L., Kjems, J. & Mian Teo, B., 9 Nov 2015, In: R S C Advances. 118, p. 97836-97840 5 p.

Serum-induced degradation of 3D DNA box origami observed with high-speed atomic force microscopy (vol 8, pg 2170, 2015)

Jiang, Z., Zhang, S., Yang, C., Zadegan, R. M., Kjems, J., Huang, Y., Besenbacher, F. & Dong, M., Oct 2015, In: Nano Research. 8, 10, p. 3446-3446 1 p.

Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense

Sun, M., Yang, C., Zheng, J., Wang, M., Chen, M., Le, D. Q. S., Kjems, J. & Bünger, C., 28 Sep 2015, In: Acta Biomaterialia. 28, p. 171–182 12 p.

Improvement of distribution and osteogenic differentiation of human mesenchymal stem cells by hyaluronic acid and β-tricalcium phosphate-coated polymeric scaffold in vitro

Chen, M., Le, D. Q. S., Kjems, J., Bünger, C. & Lysdahl, H., Sep 2015, In: BioResearch Open Access. 4, 1, p. 363-373 11 p.

Macrophage-mediated nanoparticle delivery to the periodontal lesions in established murine model via Pg-LPS induction

Ma, Z., Dagnaes-Hansen, F., Løvschall, H., Song, W., Nielsen, G. K., Yang, C., Wang, Q., Kjems, J. & Gao, S., Aug 2015, In: Journal of Oral Pathology & Medicine. 44, 7, p. 538-542 5 p.

Circular RNAs: Identification, biogenesis and function

Ebbesen, K., Kjems, J. & Hansen, T. B., 11 Jul 2015, In: Biochimica et Biophysica Acta, Gene Structure and Expression.

Monitoring patterned enzymatic polymerization on DNA origami at single-molecule level

Okholm, A. H., Aslan, H., Besenbacher, F., Dong, MD. & Kjems, J., 7 Jul 2015, In: Nanoscale. 7, 25, p. 10970-10973 4 p.

Serum induced degradation of 3D DNA box origami observed by high speed atomic force microscope

Jiang, Z., Zhang, S., Yang, C., Kjems, J., Huang, Y., Besenbacher, F. & Dong, MD., Jul 2015, In: Nano Research. 8, 7, p. 2170-2178 9 p.

Ultrastable green fluorescence carbon dots with a high quantum yield for bioimaging and use as theranostic carriers

Yang, C., Thomsen, R. P., Ogaki, R., Kjems, J. & Mian Teo, B., 14 Jun 2015, In: Journal of Materials Chemistry B. 3, 4577, p. 4577-4584 8 p.

A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo

Sun, M., Wang, M., Chen, M., Dagnaes-Hansen, F., Le, D. Q. S., Baatrup, A., Horsman, M. R., Kjems, J. & Bünger, C., May 2015, In: Acta Biomaterialia. 18, p. 21-29 9 p.

Construction of a fuzzy and all Boolean logic gates based on DNA

M. Zadegan, R., Jepsen, M. D. E., Hildebrandt, L., Birkedal, V. & Kjems, J., 17 Apr 2015, In: Small. 11, 15, p. 1811-1817 7 p.

Chitosan/siRNA functionalized titanium surface via a layer-by-layer approach for in vitro sustained gene silencing and osteogenic promotion

Song, W., Song, X., Yang, C., Gao, S., Klausen, L. H., Zhang, Y., Dong, M. & Kjems, J., 2015, In: International Journal of Nanomedicine (Online). 10, p. 2335-2346 12 p.

Electroanalysis of pM-levels of urokinase plasminogen activator in serum by phosphorothioated RNA aptamer

Jarczewska, M., Kekedy-Nagy, L., Nielsen, J. S., Campos, R., Kjems, J., Malinowska, E. & Ferapontova, E. E., 2015, In: Analyst. 140, 11, p. 3794-3802 9 p.

Electrospun PVA-PCL-HAB scaffold for craniofacial bone regeneration

Prabha, R., Kraft, D. C. E., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M., 2015, In: Tissue Engineering. Part A. 21, Supplement 1, p. S-58

In vivo drug release behavior and bone biocompatibility of doxorubicin-loaded tissue-engineered scaffold

Sun, M., Chen, M., Wang, M., Hansen, J., Le, D. Q. S., Baatrup, A., Dagnæs-Hansen, F., Rölfing, J. D., Jensen, J., Lysdahl, H., Johannsen, M., Kjems, J. & Bünger, C., 2015.

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

Opazo, F., Eiden, L., Hansen, L., Rohrbach, F., Wengel, J., Kjems, J. & Mayer, G., 2015, In: Molecular Therapy - Nucleic Acids. 4, 10 p., e251.

Profiling Osteogenic microRNAs For RNAi-Functionalization Of Scaffolds In Bone Tissue Engineering

Chang, C-C. C., Chen, L., Venø, M. T., Kassem, M. & Kjems, J., 2015.

Single Molecule FRET Analysis of the Closed and Open States of a DNA Origami Box

Jepsen, M. DE., Sørensen, R. S., Andersen, E. S., Kjems, J. & Birkedal, V., 2015, In: Biophysical Journal. 108, 2, suppl. 1, p. 175a

Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development

Venø, M. T., Hansen, T. B., Venø, S. T., Clausen, B. H., Grebing, M., Finsen, B., Holm, I. E. & Kjems, J., 2015, In: Genome Biology. 16, 17 p., 16:245.

Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

Kaalund, S. S., Venø, M. T., Bak, M., Møller, R. S., Laursen, H., Madsen, F., Broholm, H., Quistorff, B., Uldall, P., Tommerup, N., Kauppinen, S., Sabers, A., Fluiter, K., Møller, L. B., Nossent, A. Y., Silahtaroglu, A., Kjems, J., Aronica, E. & Tümer, Z., Dec 2014, In: Epilepsia. 55, 12, p. 2017-2027 11 p.

Folic Acid Conjugated Chitosan for Targeted Delivery of siRNA to Activated Macrophages in vitro and in vivo

Yang, C., Gao, S. & Kjems, J., Oct 2014, In: Journal of Materials Chemistry B. 48, p. 8608-8615 8 p.

Evidence of Stranski-Krastanov growth at the initial stage of atmospheric water condensation

Song, J., Li, Q., Wang, X., Li, J., Zhang, S., Kjems, J., Besenbacher, F. & Dong, M., 8 Sep 2014, In: Nature Communications. 5, p. 1-8 8 p., 4837.

Template-directed covalent conjugation of DNA to native antibodies, transferrin and other metal-binding proteins

Rosen, C. B., Kodal, A. L. B., Nielsen, J. S., Schaffert, D. H., Scavenius, C., Okholm, A. H., Voigt, N. V., Enghild, J. J., Kjems, J., Tørring, T. & Gothelf, K. V., Sep 2014, In: Nature Chemistry. 6, 9, p. 804-809 6 p.

Functional Analyses Reveal Extensive RRE Plasticity in Primary HIV-1 Sequences Selected under Selective Pressure

Cunyat, F., Beerens, N., Garcia, E., Clotet, B., Kjems, J. & Cabrera, C., 29 Aug 2014, In: P L o S One. 9, 8, 13 p., 106299.

Unconditioned commercial embryo culture media contain a large variety of non-declared proteins: a comprehensive proteomics analysis

Dyrlund, T. F., Kirkegaard, K., Poulsen, E. T., Sanggaard, K. W., Hindkjær, J. J., Kjems, J., Enghild, J. J. & Ingerslev, H. J., 27 Aug 2014, In: Human Reproduction. 29, 1, p. 2421-2430 10 p.

miRdentify: high stringency miRNA predictor identifies several novel animal miRNAs

Hansen, T. B., Venø, M. T., Kjems, J. & Damgaard, C. K., 22 Jul 2014, In: Nucleic Acids Research. 42, 16, p. 1-11 11 p., e124.

Treatment of Chronic Kidney Disease with Sirna Nanoparticles Targeting MMP-2

Pedersen, L. H., Kellenberger, T., Yang, C., Gao, S., Kjems, J. & Wogensen, L., 21 Jun 2014, Program and Abstract Book. The Netherlands, p. 158-158 1 p.

Chitosan Hydrogel as siRNA vector for prolonged gene silencing

Ma, Z., Yang, C., Song, W., Wang, Q., Kjems, J. & Gao, S., 19 Jun 2014, In: Journal of Nanobiotechnology. 12, 23, p. 1-9 9 p.

Quantification of cellular uptake of DNA nanostructures by qPCR

Okholm, A. H., Nielsen, J. S., Vinther, M., Sørensen, R. S., Schaffert, D. & Kjems, J., 15 May 2014, In: Methods. 67, 2, p. 193-197 5 p.

Accumulation of nano-sized particles in a murine model of angiogenesis

Wittenborn, T. R., Larsen, E. K. U., Nielsen, T., Rydtoft, L. M., Hansen, L., Nygaard, J. V., Vorup-Jensen, T., Kjems, J., Horsman, M. R. & Nielsen, N. C., 10 Jan 2014, In: Biochemical and Biophysical Research Communications. 443, 2, p. 470-6 7 p.

Advances in targeted delivery of small interfering RNA using simple bioconjugates

Nielsen, C., Kjems, J., Sorensen, K. R., Engelholm, L. H. & Behrendt, N., 1 Jan 2014, In: Expert Opinion on Drug Delivery. 11, 5, p. 791-822 32 p.

Stable assembly of HIV-1 export complexes occurs cotranscriptionally

Nawroth, I., Mueller, F., Basyuk, E., Beerens, N., Rahbek, U. L., Darzacq, X., Bertrand, E., Kjems, J. & Schmidt, U., 1 Jan 2014, In: RNA. 20, 1, p. 1-8 8 p.

Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

Yang, C., Nilsson, L., Cheema, M. U., Wang, Y., Frøkiær, J., Gao, S., Kjems, J. & Nørregaard, R., 2014, In: Theranostics. 5, 2, p. 110-123 24 p.

Fluorescence detection of natural RNA using rationally designed "clickable" oligonucleotide probes

Okholm, A., Kjems, J. & Astakhova, K., 2014, In: RSC Advances. 4, 86, p. 45653-45656 4 p.

Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing

Gao, S., Hein, S., Dagnæs-Hansen, F., Weyer, K., Yang, C., Nielsen, R., Christensen, E. I., Fenton, R. A. & Kjems, J., 2014, In: Theranostics. 4, 10, p. 1039-51 13 p.

Nucleic Acid Nanotechnology

Kjems, J. (ed.), Ferapontova, E. (ed.) & Gothelf, K. V. (ed.), 2014, Springer. 339 p. (Nucleic Acids and Molecular Biology, Vol. 29).

Preface

Kjems, J., Ferapontova, E. & Gothelf, K. V., 2014, Nucleic Acid Nanotechnology. Kjems, J., Ferapontova, E. & Gothelf, K. V. (eds.). Springer, p. ix-x 2 p. (Nucleic Acids and Molecular Biology, Vol. 29).

Sustained Drug Delivery Device for Treatment of Breast Cancer and Bone Metastases

Sun, M., Wang, M., Chen, M., Dagnæs-Hansen, F., Le, D. Q. S., Baatrup, A., Horsman, M. R., Kjems, J. & Bünger, C., 2014.

Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology

Okholm, A. H., Schaffert, D. H. & Kjems, J., 2014, Chemical Biology of Nucleic Acids. Springer, p. 325-345 20 p. (RNA Technologies).

MicroRNA-128 governs neuronal excitability and motor behavior in mice

Tan, C. L., Plotkin, J. L., Venø, M. T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O’Carroll, D., Greengard, P. & Schaefer, A., 6 Dec 2013, In: Science. 342, 6163, p. 1254-1258 5 p.

Spatially Controlled Delivery of siRNAs to Stem Cells in Implants Generated by Multi-Component Additive Manufacturing

Andersen, M. Ø., Le, D. Q. S., Chen, M., Nygaard, J. V., Kassem, M., Bünger, C. & Kjems, J., 5 Dec 2013, In: Advanced Functional Materials. 23, 45, p. 5599-5607 9 p.

An unusual topological structure of the HIV-1 Rev response element

Fang, X., Wang, J., O'Carroll, I. P., Mitchell, M., Zuo, X., Wang, Y., Yu, P., Liu, Y., Rausch, J. W., Dyba, M. A., Kjems, J., Schwieters, C. D., Seifert, S., Winans, R. E., Watts, N. R., Stahl, S. J., Wingfield, P. T., Byrd, R. A., Le Grice, S. F. J., Rein, A. & Wang, Y-X., 24 Oct 2013, In: Cell. 155, 3, p. 594-605 12 p.

A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid)

Karlsen, K. K., Okholm, A. H., Kjems, J. & Wengel, J., 15 Oct 2013, In: Bioorganic & Medicinal Chemistry. 21, 20, p. 6186-6190 6 p.

Circular RNA and miR-7 in Cancer

Hansen, T. B., Kjems, J. & Damgaard, C. K., 15 Sep 2013, In: Cancer Research. 73, 18, p. 5609-5612 4 p.

Atomic-scale structures and interactions between the guanine quartet and potassium

Xu, W., Tan, Q., Yu, M., Sun, Q., Kong, H., Lægsgaard, E., Stensgaard, I., Kjems, J., Wang, J., Wang, C. & Besenbacher, F., 21 Aug 2013, In: Chemical Communications. 49, 65, p. 7210-7212 3 p.

A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds

Zou, L., Luo, Y., Chen, M., Wang, G., Ding, M., Petersen, C. C., Kang, R., Dagnaes-Hansen, F., Zeng, Y., Lv, N., Ma, Q., Le, D. Q. S., Besenbacher, F., Bolund, L., Jensen, T. G., Kjems, J., Pu, W. T. & Bünger, C., 22 Jul 2013, In: Scientific Reports. 3, 10 p., 2243.

Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

Hansen, L., Unmack Larsen, E. K., Nielsen, E. H., Iversen, F., Liu, Z., Thomsen, K., Pedersen, M., Skrydstrup, T., Nielsen, N. C., Ploug, M. & Kjems, J., 9 Jul 2013, In: Nanoscale. 5, p. 8192-8201 10 p.

Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

Nielsen, T. O., Sorensen, S., Dagnæs-Hansen, F., Kjems, J. & Sørensen, B. S., 11 Jun 2013, In: B J C. 108, 11, p. 2291-2298 8 p.

Bioactive coronary stent coating based on layer-by-layer technology for siRNA release

Hossfeld, S., Nolte, A., Hartmann, H., Recke, M., Schaller, M., Walker, T., Kjems, J., Schlosshauer, B., Stoll, D., Wendel, H-P. & Krastev, R., May 2013, In: Acta Biomaterialia. 9, 5, p. 6741-6752 12 p.

MicroRNA functionalized microporous titanium oxide surface by lyophilization with enhanced osteogenic activity

Wu, K., Song, W., Zhao, L., Liu, M., Yan, J., Andersen, M. Ø., Kjems, J., Gao, S. & Zhang, Y., 10 Apr 2013, In: A C S Applied Materials and Interfaces. 5, 7, p. 2733-44 12 p.

MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma

Dang, J., Bian, Y., Sun, J., Chen, F., Dong, G-Y., Liu, Q., Wang, X-W., Kjems, J., Gao, S. & Wang, Q-T., Apr 2013, In: Journal of Oral Pathology & Medicine. 42, 4, p. 315-321 7 p.

Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy

Beerens, N., Jepsen, M. D. E., Nechyporuk-Zloy, V., Krüger, A. C., Darlix, J-L., Kjems, J. & Birkedal, V., Apr 2013, In: RNA. 19, 4, p. 517-26 10 p.

miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers

Hua, Y., Larsen, N., Kalyana-Sundaram, S., Kjems, J., Chinnaiyan, A. M. & Peter, M. E., 15 Mar 2013, In: B M C Genomics. 14, 179, p. 1-18 18 p.

Evaluating the accuracy of SHAPE-directed RNA secondary structure predictions

Sükösd, Z., Swenson, M. S., Kjems, J. & Heitsch, C. E., Mar 2013, In: Nucleic Acids Research. 41, 5, p. 2807-2816 10 p.

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K. & Kjems, J., 27 Feb 2013, In: Nature. 495, p. 384-388 5 p.

Comparison of bacterial cells and amine-functionalized abiotic surfaces as support for Pd nanoparticle synthesis

De Corte, S., Bechstein, S., Lokanathan, A. R., Kjems, J., Boon, N. & Meyer, R. L., 1 Feb 2013, In: Colloids and Surfaces B: Biointerfaces. 102, p. 898-904 7 p.

Novel Self-Assembled Nanoparticles of Testosterone-Modified Glycol Chitosan and Fructose Chitosan for Controlled Release

Quinones, J. P., Gothelf, K. V., Kjems, J., Heras, A., Schmidt, C. & Peniche, C., 1 Feb 2013, In: Journal of Biomaterials and Tissue Engineering. 3, 1, p. 164-172 9 p.

Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol

Quinones, J. P., Gothelf, K. V., Kjems, J., Yang, C., Caballero, A. M. H., Schmidt, C. & Peniche Covas, C., 30 Jan 2013, In: Carbohydrate Polymers. 92, 1, p. 856-864 9 p.

Characterising RNA secondary structure space using information entropy

Sükösd, Z., Knudsen, B., Anderson, J. WJ., Novák, A., Kjems, J. & Pedersen, C. N. S., 21 Jan 2013, In: B M C Bioinformatics. 14 , Suppl 2, p. 1-9 9 p., S22.

N,O6-partially acetylated chitosan nanoparticles hydrophobically-modified for controlled release of steroids and vitamin E

Quinones, J. P., Gothelf, K. V., Kjems, J., Caballero, A. M. H., Schmidt, C. & Covas, C. P., 2 Jan 2013, In: Carbohydrate Polymers. 91, 1, p. 143-151 9 p.

Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model

Nawroth, I., Alsner, J., Deleuran, B. W., Dagnæs-Hansen, F., Yang, C., Horsman, M. R., Overgaard, J., Howard, K., Kjems, J. & Gao, S., 1 Jan 2013, In: Acta Oncologica. 52, 8, p. 1730-1738 9 p.

Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles

Gonzalez, B. B., Dagnæs-Hansen, F., Fenton, R. A., Gao, S., Hein, S., Dong, M., Kjems, J. & Howard, K. A., 1 Jan 2013, In: Molecular Therapy - Nucleic Acids. 2, 1, p. 1-8 8 p., e76.

Biological activity and biotechnological aspects of locked nucleic acids

Lundin, K. E., Højland, T., Hansen, B., Persson, R., Bramsen, J. B., Kjems, J., Koch, T., Wengel, J. & Smith, C. I. E., 2013, In: Advances in Genetics. 82, p. 47-107 61 p.

Engineering small interfering RNAs by strategic chemical modification

Bramsen, J. B. & Kjems, J., 2013, siRNA design: methods and protocols. Taxman, D. J. (ed.). Springer, p. 87-109 23 p. (Methods in Molecular Biology, Vol. 942).

Enzymatic Ligation of Large Biomolecules to DNA

Sørensen, R. S., Okholm, A. H., Schaffert, D. H., Kodal, A. L. B., Gothelf, K. V. & Kjems, J., 2013, In: ACS Nano. 7, 9, p. 8098-8104 7 p.

Free radicals generated by tantalum implants antagonize the cytotoxic effect of doxorubicin

Chen, M., Hein, S., Le, D. Q. S., Feng, W., Foss, M., Kjems, J., Besenbacher, F., Zou, X. & Bünger, C., 2013, In: International Journal of Pharmaceutics. 448, 1, p. 214-20 7 p.

Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

Iversen, F., Yang, C., Dagnæs-Hansen, F., Schaffert, D. H., Kjems, J. & Gao, S., 2013, In: Theranostics. 3, 3, p. 201-209 9 p.

RNA aptamer-based electrochemical biosensor for selective and label-free analysis of dopamine

Farjami, E., Campos, R., Nielsen, J. S., Gothelf, K. V., Kjems, J. & Ferapontova, E., 2013, In: Analytical Chemistry. 85, 1, p. 121-128 8 p.

The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine

Andersen, M. Ø., Dillschneider, P. & Kjems, J., 2013, RNA Interference from Biology to Therapeutics. Howard, K. A. (ed.). Springer, p. 57-78 22 p. (Advances in Delivery Science and Technology).

Construction of a 4 Zeptoliters Switchable 3D DNA Box Origami

Zadegan, R. M., Jepsen, M. DE., Thomsen, K. E., Okholm, A. H., Schaffert, D. H., Andersen, E. S., Birkedal, V. & Kjems, J., 27 Nov 2012, In: A C S Nano. 6, 11, p. 10050-10053 4 p.

PPfold 3.0: fast RNA secondary structure prediction using phylogeny and auxiliary data

Sükösd, Z., Knudsen, B., Kjems, J. & Pedersen, C. N. S., 9 Nov 2012, In: Bioinformatics. 28, 20, p. 2691-2692 2 p.

A distant cis acting intronic element induces site-selective RNA editing

Daniel, C., Venø, M. T., Ekdahl, Y., Kjems, J. & Öhman, M., Oct 2012, In: Nucleic Acids Research. 40, 19, p. 9876-9886 11 p.

Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

Venø, M. T., Bramsen, J. B., Bendixen, C., Panitz, F., Holm, I. E., Öhman, M. & Kjems, J., Aug 2012, In: RNA Biology. 9, 8, p. 1054-1065 12 p.

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

Schyth, B. D., Bramsen, J. B., Pakula, M. M., Larashati, S., Kjems, J., Wengel, J. & Lorenzen, N., Jul 2012, In: Nucleic Acids Research. 40, 10, p. 4653-4665 12 p.

Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery

Chen, M., Gao, S., Dong, M., Song, J., Yang, C., Howard, K. A., Kjems, J. & Besenbacher, F., 26 Jun 2012, In: A C S Nano. 6, 6, p. 4835-4844 10 p.

MicroRNA expression profiling of carcinoma in situ (CIS) cells of the testis

Novotny, G. W., Belling, K. C., Bramsen, J. B., Nielsen, J. E., Bork-Jensen, J., Almstrup, K., Sonne, S. B., Kjems, J., Rajpert-De Meyts, E. & Leffers, H., 1 Jun 2012, In: Endocrine - Related Cancer. p. 365-379 15 p.

Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes

Bellemer, C., Bortolin-Cavaillé, M-L., Schmidt, U., Jensen, S. M. R., Kjems, J., Bertrand, E. & Cavaillé, J., 1 Jun 2012, In: Journal of Cell Science. 125, p. 2709-2720 12 p.

Self-assembled nanoparticles of glycol chitosan – Ergocalciferol succinate conjugate, for controlled release

Quinones, J. P., Gothelf, K. V., Kjems, J., Caballero, A. M. H., Schmidt, C. & Covas, C. P., 16 May 2012, In: Carbohydrate Polymers. 88, 4, p. 1373-1377 5 p.

Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

Larsen, E. K. U., Nielsen, T., Wittenborn, T., Rydtoft, L. M., Lokanathan, A. R., Hansen, L., Østergaard, L., Kingshott, P., Howard, K. A., Besenbacher, F., Nielsen, N. C. & Kjems, J., 6 Mar 2012, In: Nanoscale. 4, 7, p. 2352-2361 10 p.

Stable Cell Lines with Splicing Reporters

Damgaard, C. K., Lykke-Andersen, S. & Kjems, J., 2 Feb 2012, Alternative pre-mRNA Splicing: Theory and Protocols. Stamm, S., Smith, C. W. J. & Luhrmann, R. (eds.). 1 ed. Wiley-VCH, p. 408-414

tRNA Annealing onto the HIV-1 Genome Studied by FRET Spectroscopy and Microscopy

Jepsen, M., Beerens, N., Krüger, A. C., Kjems, J. & Birkedal, V., 31 Jan 2012, In: Biophysical Journal. 102, 3, Supplement 1, p. 278a 1 p.

The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer

Villadsen, S. B., Bramsen, J. B., Ostenfeld, M. S., Wiklund, E. D., Fristrup, N., Gao, S., Hansen, T. B., Jensen, T. I., Borre, M., Orntoft, T. F., Dyrskjøt, L. & Kjems, J., 17 Jan 2012, In: B J C. 106, 2, p. 366-374 9 p.

Composition useful as a medicament for treating cancer and/or neuropsychiatric disorders, comprises a binding member capable of binding to a human epidermal growth factor (EGF) receptor 4 (HER4) polypeptide and/or a HER4 RNA

Østergaard, T., Sørensen, B. S., Sørensen, S. & Kjems, J., 2012, Patent No. WO2011107100-A1

Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering

Bramsen, J. B. & Kjems, J., 2012, In: Frontiers in Genetics. 3, p. 154 22 p.

Fabrication and characterization of a rapid prototyped tissue engineering scaffold with embedded multicomponent matrix for controlled drug release

Chen, M., Le, D. Q. S., Hein, S., Li, P., Nygaard, J. V., Kassem, M., Kjems, J., Besenbacher, F. & Bünger, C., 2012, In: International Journal of Nanomedicine (Online). 7, p. 4285-97 13 p.

Functional selection of shRNA loops from randomized retroviral libraries

Jensen, S. M. R., Schmitz, A., Pedersen, F. S., Kjems, J. & Bramsen, J. B., 2012, In: P L o S One. 7, 8, p. e43095 7 p.

MicroRNA cloning and sequencing in osteosarcoma cell lines:differential role of miR-93

Montanini, L., Lasagna, L., Barili, V., Jonstrup, S. P., Murgia, A., Pazzaglia, L., Conti, A., Novello, C., Kjems, J., Perris, R. & Benassi, M. S., 2012, In: Cellular oncology (Dordrecht). 35, 1, p. 29-41 13 p.

Oligonucleotide delivery to the lung: waiting to inhale

Kjems, J. & Howard, K., 2012, In: Molecular Therapy - Nucleic Acids. 1, p. e1 2 p.

Ultra-High-Field DCE-MRI of Angiogenesis in a Novel Angiogenesis Mouse Model

Wittenborn, T., Nielsen, T., Nygaard, J. V., Larsen, E. K. U., Thim, T., Rydtoft, L. M., Vorup-Jensen, T., Kjems, J., Nielsen, N. C., Horsman, M. R. & Falk, E., 2012, In: Journal of Magnetic Resonance Imaging. 35, 3, p. 703-710 7 p.

MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma

Wiklund, E. D., Gao, S., Hulf, T., Sibbritt, T., Nair, S., Costea, D. E., Villadsen, S. B., Bakholdt, V., Bramsen, J. B., Sorensne, J. A., Krogdahl, A., Clark, S. J. & Kjems, J., 22 Nov 2011, In: P L o S One. 61, 1, p. e27840 (1-11) 11 p.

miRConnect:Identifying effector genes of miRNAs and miRNA families in cancer cells

Hua, Y., Duan, S., Murmann, A. E., Larsen, N., Kjems, J., Lund, A. H. & Peter, M. E., 26 Oct 2011, In: P L o S One. 6, 10, p. e26521 16 p.

TISSUE SCAFFOLD WITH CONTROLLED DRUG RELEASE

Chen, M., Hein, S., Le, D. Q. S., Nygaard, J. V., Bünger, C. & Kjems, J., 7 Oct 2011, Patent No. PCT/DK2011/050381, 7 Oct 2011

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J. & Kjems, J., 30 Sep 2011, In: E M B O Journal. 30, 21, p. 4414-4422 9 p.

Homochiral Xanthine Quintet Networks Self-Assembled on Au(111) Surfaces

Yu, M., Wang, J., Mura, M., Meng, Q-Q., Xu, W., Gersen, H., Lægsgaard, E., Stensgaard, I., Kelly, R. E. A., Kjems, J., Linderoth, T. R., Kantorovich, L. N. & Besenbacher, F., 19 Jul 2011, In: ACS Nano. 5, 8, p. 6651-6660 10 p.

Single molecule microscopy methods for the study of DNA origami structures

Birkedal, V., Dong, M., Golas, M. M., Sander, B., Andersen, E. S., Gothelf, K. V., Besenbacher, F. & Kjems, J., Jul 2011, In: Microscopy Research and Technique. 74, 7, p. 688-698 11 p.

G-quadruplex structures in telomeric DNA studied with single molecule FRET microscopy

Krüger, A. C., Nielsen, M. M., Kjems, J., Besenbacher, F. & Birkedal, V., 28 Jun 2011.

Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis

Hansen, T. B., Kjems, J. & Bramsen, J. B., Jun 2011, In: RNA Biology. 8, 3, p. 378-383 6 p.

Neuronal and glial responses to siRNA-coated nerve guide implants in vitro

Hoffmann, N., Mittnacht, U., Hartmann, H., Baumer, Y., Kjems, J., Oberhoffner, S. & Schlosshauer, B., 20 Apr 2011, In: Neuroscience Letters. 494, 1, p. 14-8 5 p.

Multithreaded comparative RNA secondary structure prediction using stochastic context-free grammars

Sükösd, Z., Knudsen, B., Værum, M., Kjems, J. & Andersen, E. S., 18 Apr 2011, In: B M C Bioinformatics. 12, 103

Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

Wiklund, E. D., Bramsen, J. B., Hulf, T., Andersen, L. D., Ramanathan, R., Hansen, T. B., Villadsen, S. B., Gao, S., Ostenfeld, M. S., Borre, M., Peter, M. E., Ørntoft, T. F., Kjems, J. & Clark, S. J., 15 Mar 2011, In: International Journal of Cancer. 128, 6, p. 1327-1334 8 p.

Site-Specific Chemical Labeling of Long RNA Molecules

Jahn, K., Olsen, E. M., Nielsen, M. M., Tørring, T., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J., 19 Jan 2011, In: Bioconjugate Chemistry. 22, 1, p. 95-100 6 p.

S1 nuclease analysis of alternatively spliced mRNA

Lützelberger, M. & Kjems, J., 1 Jan 2011, In: Methods in Molecular Biology. 703, p. 161-71 11 p.

A DNA tile actuator with eleven discrete states

Zhang, Z., Olsen, E. M., Kryger, M., Voigt, N. V., Tørring, T., Gültekin, E., Nielsen, M., MohammadZadegan, R., Andersen, E. S., Nielsen, M. M., Kjems, J., Birkedal, V. & Gothelf, K. V., 2011, In: Angewandte Chemie International Edition. 50, 17, p. 3983-7 5 p.

Chemical modification of small interfering RNA

Bramsen, J. B. & Kjems, J., 2011, In: Methods in Molecular Biology. 721, 1, p. 77-103 27 p.

Conformational changes of HIV-1 RNA upon tRNA primer annealing studied by ensemble and single-molecule FRET

Jepsen, M. DE., Beerens, N., Besenbacher, F., Kjems, J. & Birkedal, V., 2011. 1 p.

Functional Patterning of DNA Origami by Parallel Enzymatic Modification

Jahn, K., Tørring, T., Voigt, N. V., Sørensen, R. S., Kodal, A. L. B., Andersen, E. S., Gothelf, K. V. & Kjems, J., 2011, In: Bioconjugate Chemistry. 22, 4, p. 819-823

Process for Modifying the Surface Morphology of a Medical Device: PA 2011 70752

Le, D. Q. S., Andersen, M. Ø., Baatrup, A., Chen, M., Chen, M., Lysdahl, H., Besenbacher, F., Bünger, C. & Kjems, J., 2011

RNA aptamers to the cancer-associated proteins UPA and PAI-1 with therapeutic potential

Dupont, D. M., Madsen, J. B., Bøtkjær, K. A., Tavitian, B., Duconge, F., Kjems, J. & Andreasen, P., 2011, In: Nucleic Acid Therapeutics. 21, 5

Single molecule FRET microscopy studies of tRNA annealing onto the HIV-1 genome

Jepsen, M. B., Beerens, N., Nechyponuk-Zloy, V., Besenbacher, F., Kjems, J. & Birkedal, V., 2011.

Bioresponsive hyperbranched polymers for siRNA and miRNA delivery

Rahbek, U. L., Nielsen, A. F., Dong, M., You, Y., Chauchereau, A., Oupicky, D., Besenbacher, F., Kjems, J. & Howard, K. A., 1 Dec 2010, In: Journal of Drug Targeting. 18, 10, p. 812-20 9 p.

Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding

Dupont, D. M., Madsen, J. B., Hartmann, R. K., Tavitian, B., Ducongé, F., Kjems, J. & Andreasen, P. A., 1 Dec 2010, In: RNA. 16, 12, p. 2360-9 10 p.

Single Molecule Atomic Force Microscopy Studies of Photosensitized Singlet Oxygen Behavior on a DNA Origami Template

Helmig, S. W., Rotaru, A., Arian, D., Kovbasyuk, L., Arnbjerg, J., Ogilby, P. R., Kjems, J., Mokhir, A., Besenbacher, F. & Gothelf, K. V., 22 Nov 2010, In: A C S Nano. 4, 12, p. 7475-7480

Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth

Mittnacht, U., Hartmann, H., Hein, S., Oliveira, H., Dong, M., Pêgo, A. P., Kjems, J., Howard, K. A. & Schlosshauer, B., 13 Oct 2010, In: Nano Letters. 10, 10, p. 3933-9 7 p.

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Nawroth, I., Alsner, J., Behlke, M. A., Besenbacher, F., Overgaard, J., Howard, K. A. & Kjems, J., 1 Oct 2010, In: Radiotherapy & Oncology. 97, 1, p. 143-8 6 p.

Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction

Schaefer, A., Im, H-I., Venø, M. T., Fowler, C. D., Min, A., Intrator, A., Kjems, J., Kenny, P. J., O'Carroll, D. & Greengard, P., 30 Aug 2010, In: Journal of Experimental Medicine. 207, 9, p. 1843-51 9 p.

Surface functionalisation of PLGA nanoparticles for gene silencing

Andersen, M. Ø., Lichawska, A., Arpanaei, A., Jensen, S. M. R., Kaur, H., Oupicky, D., Besenbacher, F., Kingshott, P., Kjems, J. & Howard, K. A., Jul 2010, In: Biomaterials. 31, 21, p. 5671-5677 7 p.

Re-inspection of small RNA sequence datasets reveals several novel human miRNA genes

Hansen, T. B., Bramsen, J. B. & Kjems, J., 4 Jun 2010, In: P L o S One. 5, 6, p. e10961 3 p.

Circularization of the HIV-1 genome facilitates strand transfer during reverse transcription

Beerens, N. & Kjems, J., 1 Jun 2010, In: RNA. 16, 6, p. 1226-35 10 p.

RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1

Madsen, J. B., Dupont, D. M., Andersen, T. B., Nielsen, A. F., Sang, L., Brix, D. M., Jensen, J. K., Broos, T., Hendrickx, M. L. V., Christensen, A., Kjems, J. & Andreasen, P. A., 18 May 2010, In: Biochemistry. 49, 19, p. 4103-15 13 p.

miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors

Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Dalsgaard Sørensen, K., Ulhøi, B. P., Borre, M., Kjems, J., Andersen, L. D. & Ørntoft, T. F., 18 Feb 2010, In: Oncogene. 29, 7, p. 1073 12 p.

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Bramsen, J. B., Pakula, M. M., Hansen, T. B., Bus, C., Langkjær, N., Odadzic, D., Smicius, R., Wengel, S. L., Chattopadhyaya, J., Engels, J. W., Herdewijn, P., Wengel, J. & Kjems, J., 2010, In: Nucleic Acids Research. 38, 17, p. 5761-5773 13 p.

Crosstalk between mRNA 3’ end processing and transcription initiation

Mapendano, C. K., Lykke-Andersen, S., Kjems, J., Bertrand, E. & Jensen, T. H., 2010, In: Molecular Cell. 40, p. 410-422

Curvature of Synthetic and Natural Surfaces is an Important Target Feature in Classical Pathway Complement Activation

Pedersen, M. B., Zhou, X., Larsen, E. K. U., Sørensen, U. S., Kjems, J., Nygaard, J. V., Nyengaard, J. R., Meyer, R. L., Boesen, T. & Vorup-Jensen, T., 2010, In: Journal of Immunology. 184, 4, p. 1931-1945 15 p.

David versus Goliath

Mollenhauer, J., Stamou, D., Flyvbjerg, A., Wengel, J., Gether, U., Kjems, J., Bjørnholm, T. & Besenbacher, F., 2010, In: Nanomedicine: Nanotechnology, Biology and Medicine. 6, 4, p. 504-9 6 p.

Differential approach to define microRNA expression patterns in osteosarcomas

Montanini, L., Pazzaglia, L., Spessotto, P., Kjems, J., Conti, A., Perris, R., den Boer, M. L. & Benassi, M. S., 2010, In: Proceedings of the American Association of Cancer Research. 51

Epigenetic architecture and miRNA: reciprocal regulators

Wiklund, E. D., Kjems, J. & Clark, S. J., 2010, In: Epigenomics. 2, 6, p. 823-40 18 p.

FRET-studies of the HIV-1 genome upon tRNA annealing

Jepsen, M. DE., Nechyponuk-Zloy, V., Beerens, N., Besenbacher, F., Kjems, J. & Birkedal, V., 2010. 1 p.

Interaction of hnRNP A1 with telomere DNA G-quadruplex structures studied at the single molecule level

Krüger, A. C., Raarup, M. K., Nielsen, M. M., Kristensen, M., Besenbacher, F., Kjems, J. & Birkedal, V., 2010, In: European Biophysics Journal. 39, 9, p. 1343-1350

Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles

Nielsen, E. J. B., Nielsen, J. M., Becker, D., Karlas, A., Prakash, H., Glud, S. Z., Merrison, J., Besenbacher, F., Meyer, T. F., Kjems, J. & Howard, K. A., 2010, In: Pharmaceutical Research. 27, 12, p. 2520-7 7 p.

Single-molecule chemical reactions on DNA origami

Voigt, N. V., Tørring, T., Rotaru, A., Jacobsen, M. F., Ravnsbæk, J. B., Subramani, R., Mamdouh, W., Kjems, J., Mokhir, A., Besenbacher, F. & Gothelf, K. V., 2010, In: Nature Nanotechnology. 5, 3, p. 200-203

Supramolecular porous network formed by molecular recognition between chemically modified nucleobases guanine and cytosine

Xu, W., Wang, J-G., Jacobsen, M. F., Mura, M., Yu, M., Kelly, R. E. A., Meng, Q-Q., Lægsgaard, E., Stensgaard, I., Linderoth, T. R., Kjems, J., Kantorovich, L. N., Gothelf, K. V. & Besenbacher, F., 2010, In: Angewandte Chemie International Edition. 49, 49, p. 9373-7 5 p.

Treatment of radiation-induced fibrosis

Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I., 2010, Patent No. WO2010085959A1, 28 Jan 2010

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

Laursen, M. B., Pakula, M. M., Gao, S., Fluiter, K., Mook, O. R., Baas, F., Langklaer, N., Wengel, S. L., Wengel, J., Kjems, J. & Bramsen, J. B., 2010, In: Molecular BioSystems. 6, 5, p. 862-70 9 p.

siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells

Andersen, M. Ø., Nygaard, J. V., Burns, J. S., Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J., 2010, In: Molecular Therapy. 18, 11, p. 2018-2027 10 p.

Site-specific labeling of long HIV-1 RNA using DNA templated chemistry

Jahn, K., Nielsen, M. M., Olsen, E. M., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J., 1 Dec 2009, p. 84-88. 5 p.

Nanoparticle-mediated treatment for inflammatory

Kjems, J., Howard, K. A., Besenbacher, F. & Deleuran, B., 29 Jan 2009, IPC No. C12N 15/11 (2006.01), A61K 31/713 (2006.01), C12N 15/87 (2006.01), Patent No. WO/2009/012786, 29 Jan 2009

Guld får medicinen frem i kroppen

Andersen, M. G. & Kjems, J., 9 Jan 2009, In: Aktuellt i Politiken. 1 p.

A Novel in Vivo Angiogenesis Mouse Model

Wittenborn, T., Nygaard, J. V., Horsman, M. R., Vorup-Jensen, T., Kjems, J., Thim, T., Nielsen, T., Larsen, E. K. U. & Falk, E., 2009, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 7

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Bramsen, J. B., Laursen, M. B., Nielsen, A. F., Hansen, T. B., Bus, C., Langkjær, N., Babu, B. R., Højland, T., Abramov, M., Van Aerschot, A., Odadzic, D., Smicius, R., Haas, J., Andree, C., Barman, J., Wenska, M., Srivastava, P., Zhou, C., Honcharenko, D., Hess, S., Müller, E., Bobkov, G. V., Mikhailov, S. N., Fava, E., Meyer, T. F., Chattopadhyaya, J., Zerial, M., Engels, J. W., Herdewijn, P., Wengel, J. & Kjems, J., 2009, In: Nucleic Acids Research. 37, 9, p. 2867-81 15 p.

Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration.

Hartmann, H., Lakner, U., Andersen, M. Ø., Kjems, J., Howard, K. A. & Schloßhauer, B., 2009, In: Tissue Engineering. Part A. Tissue Engineering. 3, p. 718

Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium

Mistry, A., Glud, S. Z., Kjems, J., Nyengaard, J. R., Howard, K. A., Stolnik, S. & Illum, L., 2009, In: Journal of Drug Evaluation. 17, 7, p. 543-552 10 p.

Endosomal Trafficking of HIV-1 Gag and Genomic RNAs Regulates Viral Egress

Molle, D., Segura-Morales, C., Camus, G., Berlloz-Forrent, C., Kjems, J., Basyuk, E. & Bertrand, E., 2009, In: Journal of Biological Chemistry. 284, 29, p. 19727-19743

Experimental Molecular Biology: Laboratory Course Manual

Kristensen, T., Christensen, M. S., Jensen, T. H., Kjems, J., Gylling, A. & Scheving, M., 2009

Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.

Andersen, L. D., Ostenfeld, M. S., Bramsen, J. B., Silahtaroglu, A., Lamy, P., Ramanathan, R., Fristrup, N., Jensen, J. L., Andersen, C. L., Zieger, K., Kauppinen, S., Ulhøi, B. P., Kjems, J., Borre, M. & Ørntoft, T. F., 2009, In: Cancer Research. 69, 11, p. 4851-60 9 p.

Interactions between the human telomeric G-quadruplex and hnRNP A1 studied by single-molecule FRET

Krüger, A. C., Nielsen, M. M., Lützelberger, M., Raarup, M. K., Kristensen, M., Kjems, J., Besenbacher, F. & Birkedal, V., 2009.

Methods for single molecule FRET microsocpy data analysis

Birkedal, V., Krüger, A. C., Nochyporuk-Zloy, V., Kjems, J. & Besenbacher, F., 2009.

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration

Glud, S. Z., Bramsen, J. B., Dagnaes-Hansen, F., Wengel, J., Howard, K. A., Nyengaard, J. R. & Kjems, J., 2009, In: Oligonucleotides. 19, 2, p. 163-8 5 p.

Polycaprolactone nanomesh cultured with hMSC evaluated by synchrotron tomography

Nygaard, J. V., Andersen, M. Ø., Cloetens, P., Foss, M., Kassem, M., Kjems, J. & Besenbacher, F., 2009. 1 p.

RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications

Andersen, M. Ø., Howard, K. A. & Kjems, J., 2009, Methods in Molecular Biology. Vol. 555. p. 77-86 10 p. (Methods in Molecular Biology).

Self-assembly of a nanoscale DNA box with a controllable lid

Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B., Stark, H., Oliveira, C. L. P., Pedersen, J. S., Birkedal, V., Besenbacher, F., Gothelf, K. V. & Kjems, J., 2009, In: Nature. 459, 7243, p. 73-6 3 p.

Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors

Larsen, E. K. U., Nielsen, T., Wittenborn, T., Birkedal, H., Vorup-Jensen, T., Jakobsen, M. H., Østergaard, L., Horsman, M. R., Besenbacher, F., Howard, K. A. & Kjems, J., 2009, In: A C S Nano. 3, 7, p. 1947-51 5 p.

Structure of the HIV-1 Rev response element alone and in complex with regulator of virion (Rev) studied by atomic force microscopy

Pallesen, J., Dong, M., Besenbacher, F. & Kjems, J., 2009, In: F E B S Journal. 276, 15, p. 4223-32 9 p.

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice

Gao, S., Dagnæs-Hansen, F., Nielsen, E. J. B., Wengel, J., Besenbacher, F., Howard, K. A. & Kjems, J., 2009, In: Molecular Therapy. 17, 7, p. 1225-1233 9 p.

miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors

Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Ulhøi, B. P., Borre, M., Kjems, J., Dyrskjøt, L. & Ørntoft, T. F., 2009, In: Oncogene.

Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy

Nygaard, J. V., Andersen, M. Ø., Howard, K. A., Foss, M., Bünger, C., Kjems, J. & Besenbacher, F., 1 Jul 2008, In: Biotechnology and Bioengineering (Print). 100, 4, p. 820-9 10 p.

A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo

Damgaard, C. K., Kahns, S., Lykke-Andersen, S., Nielsen, A. L., Jensen, T. H. & Kjems, J., Feb 2008, In: Molecular Cell. 29, 2, p. 271-278 8 p.

Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference

Odadzic, D., Bramsen, J. B., Smicius, R., Bus, C., Kjems, J. & Engels, J. W., Jan 2008, In: Bioorganic & Medicinal Chemistry. 16, 1, p. 518-529 12 p.

A new way of targeting protease-receptor binding: Selection of uPA binding RNA aptamers inhibiting its association to its receptor uPAR

Dupont, D. M., Kjems, J., Andreasen, P. & Madsen, J. C. B., 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. p. 443-443 1 p.

Chitosan composites forbiomedical applications: status, challenges and perspectives

Hein, S., Wang, K., Stevens, W. & Kjems, J., 2008, In: Materials Science and Technology. 24, p. 1053-1061

Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model

Howard, K. A., Paludan, S. R., Behlke, M. A., Besenbacher, F., Deleuran, B. W. & Kjems, J., 2008, In: Molecular Therapy. 17, 1, p. 162-168 7 p.

Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions

Torarinsson, E., Yao, Z., Wiklund, E. D., Bramsen, J. B., Hansen, C. A., Kjems, J., Tommerup, N., Ruzzo, W. L. & Gorodkin, J., 2008, In: Genome Research. 18, 2, p. 242-251 10 p.

DNA origami design of dolphin-shaped structures with flexible tails

Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Lind-Thomsen, A., Mamdouh, W., Gothelf, K. V., Besenbacher, F. & Kjems, J., 2008, In: A C S Nano. 2, 6, p. 1213-8 5 p.

Delivery of siRNA from lyophilized polymeric surfaces

Andersen, M. Ø., Howard, K. A., Paludan, S. R., Besenbacher, F. & Kjems, J., 2008, In: Biomaterials. 29, 4, p. 506-512 7 p.

Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides

Rahbek, U. L., Howard, K. A., Oupicky, D., Manickam, D. S., Dong, M., Nielsen, A. F., Hansen, T. B., Besenbacher, F. & Kjems, J., 2008, In: Journal of Gene Medicine. 10, 1, p. 81-93 12 p.

Nanoscaffolds for Drug Delivery and Tissue Engineering

Nygaard, J. V., Andersen, M. Ø., Cloetens, P., Foss, M., Kassem, M., Kjems, J. & Besenbacher, F., 2008.

Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture

Astakhova, I., Korshun, V. A., Jahn, K., Kjems, J. & Wengel, J., 2008, In: Bioconjugate Chemistry. 19, 10, p. 1995-2007 13 p.

Protein detection with a planar photonic-crystal sensor

Skivesen, N., Tetu, A., Kristensen, M., Kjems, J., Frandsen, L. H. & Borel, P. I., 2008.

Reintroduction of bladder cancer-downregulated miR-145 results in massive cell death of bladder cancer cell lines

Bramsen, J. B., Kjems, J., Ørntoft, T. F., Andersen, L. D. & Ostenfeld, M. S., 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. p. 417-417 1 p.

Software package for the design and analysis of DNA origami structures

Andersen, E. S., Nielsen, M. M., Dong, M., Besenbacher, F., Kjems, J. & Gothelf, K. V., 2008. 5 p.

Specificity of Watson-Crick Base Pairing on a Solid Surface Studied at the Atomic Scale

Otero Martin, R., Xu, W., Lukas, M., Kelly, R. E. A., Laegsgaard, E., Stensgaard, I., Kjems, J., Kantorovich, L. N. & Besenbacher, F., 2008, In: Angewandte Chemie. 47, 50, p. 9673-9676 4 p.

Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer

Nielsen, K. B., Sørensen, S., Cartegni, L., Corydon, T. J., Doktor, T. K., Schroeder, L. D., Reinert, L. S., Elpeleg, O., Krainer, A. R., Gregersen, N., Kjems, J. & Andresen, B. S., 1 Mar 2007, In: American Journal of Human Genetics. 80, 3, p. 416-432 17 p.

A novel type of agent blocking the association of uPA to its receptor uPAR: uPA-binding aptamers

Dupont, D. M., Madsen, J. B., Kjems, J. & Andreasen, P., 2007.

Alternative splicing of the ADAR1 transcript in a region that functions either as a 5'-UTR or an ORF

Lykke-Andersen, S., Piñol-Roma, S. & Kjems, J., 2007, In: RNA. 13, 10, p. 1732-1744 13 p.

Antibody-based protein detection using piezoresistive cantilever array

Dauksaite, V., Lorentzenn, M., Besenbacher, F. & Kjems, J., 2007, In: Nanotechnology. 18, p. 1-5 4 p.

Chitosan/siRNA nanoparticles for gene silencing: formulation and characterization.

Liu, X., Howard, K. A., Dong, M. & Kjems, J., 2007, In: Biomaterials. 28, p. 1280-1288 8 p.

Direct force measurements between siRNA and chitosan molecules using force spectroscopy

Xu, S., Dong, M., Liu, X., Howard, K. A., Kjems, J. & Besenbacher, F., 2007, In: Biophysical Journal. 93, 3, p. 952-9 7 p.

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

Jakobsen, M. R., Haasnoot, J., Wengel, J., Berkhout, B. & Kjems, J., 2007, In: Retrovirology. 4, 29, p. 1-13 13 p.

Improved silencing properties using small internally segmented interfering RNAs

Bramsen, J. B., Laursen, M. B., Damgaard, C. K., Lena, S. W., Babu, B. R., Wengel, J. & Kjems, J., 2007, In: Nucleic Acids Research. 35, 17, p. 5886-5897 12 p.

Localized Delivery of Lyophilized siRNA polyplexes

Bak, R. O., Andersen, M. Ø., Howard, K. A. & Kjems, J., 2007. 1 p.

Metal-clad waveguides anvendt som optiske  bio-sensorer

Skivesen, N., Kristensen, M., Kjems, J., Frandsen, L. H., Borel, P. I. & Tetu, A., 2007, In: D O P S - Nyt. 07, 1, p. 20 25 p.

Nanocarrier stimuli-activated gene delivery

Howard, K. A., Dong, M., Oupicky, D., Bisht, H. S., Buss, C., Besenbacher, F. & Kjems, J., 2007, In: Small. 3, 1, p. 54-7 3 p.

Photonic-crystal waveguide biosensor

Skivesen, N., Têtu, A., Kristensen, M., Kjems, J., Frandsen, L. H. & Borel, P. I., 2007, In: Optics Express. 15, 6, p. 3169-3176 8 p.

Planar photonic crystal waveguide biosensor

Skivesen, N., Tetu, A., Kristensen, M., Kjems, J., Frandsen, L. H. & Borel, P. I., 2007.

Polycation-based nanoparticle delivery for improved RNA interference therapeutics

Howard, K. A. & Kjems, J., 2007, In: Expert opinion on biological therapy. 7, 12, p. 1811-1822 12 p.

Polycation-based nanoparticle delivery for improved RNAi therapeutics

Howard, K. A. & Kjems, J., 2007, In: Expert Opin. Biol. Ther. 7, p. 1811-1822

Semiautomated improvement of RNA alignments

Andersen, E. S., Lind-Thomsen, A., Knudsen, B., Kristensen, S. E., Havgaard, J. H., Torarinsson, E., Larsen, N., Zwieb, C., Sestoft, P., Kjems, J. & Gorodkin, J., 2007, In: RNA. 13, p. 1850-1859 10 p.

Surface delivery of siRNA for implants

Andersen, M. Ø., Nygaard, J. V., Howard, K., Bak, R. O., Paludan, S. R., Raarup, M. K., Besenbacher, F. & Kjems, J., 2007, In: European Cells & Materials. 14, 3, p. 118 1 p.

The human ADAR1 transcripts contain an alternative retained intron within a region that functions both as a 5'UTR and an ORF

Lykke-Andersen, S., Piñol-Roma, S. & Kjems, J., 2007, In: RNA. 89, 10, 1732 p.

The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing

Liu, X., Howard, K. A., Dong, M., Andersen, M. Ø., Rahbek, U. L., Johnsen, M. G., Hansen, O. C., Besenbacher, F. & Kjems, J., 2007, In: Biomaterials. 28, 6, p. 1280-8 8 p.

Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster

Novotny, G. W., Sonne, S., Nielsen, J. E., Jonstrup, S. P., Hansen, M. A., Skakkebaek, N. E., Rajpert-De Meyts, E., Kjems, J. & Leffers, H., 2007, In: Cell Death and Differentiation. 14, 4, p. 879-882 4 p.

Visualisation of Thermal Activated Nanocarriers Using In Situ Atomic Force Microscopy

Dong, M., Howard, K. A., Oupicky, D., Bisht, H. J., Kjems, J. & Besenbacher, F., 2007, In: Nanotechnology.

The strength of the HIV-1 3' splice sites affects Rev function

Kammler, S., Otte, M., Hauber, I., Kjems, J., Hauber, J. & Schaal, H., Dec 2006, In: Retrovirology. 3, 89, p. 1-20 20 p.

A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability

Lützelberger, M., Reinert, L. S., Das, A. T., Berkhout, B. & Kjems, J., 7 Jul 2006, In: Journal of Biological Chemistry. 281, 27, p. 18644-18651 8 p.

HIV-1 reverse Transcriptase Gene 103K/N and 184M/V Combinations in Tandem: Detection and Quantification of HIV-1 Populations in the CD45RO+ T-cell Compartment by a Double-ARMS Real-Time PCR assay

Mohey, R., Tolstrup, M., Jørgensen, L. B., Møller, B. K., Black, F. T., Kjems, J. & Obel, N., 1 Feb 2006, In: J A I D S. 41, 2, p. 160-167 8 p.

The Effect of a Single Nucleotide Substitution in the Splicing Silencer in the tat/rev Intron on HIV Type 1 Envelope Expression

Paca-Uccaralertkun, S., Damgaard, C. K., Auewarakul, P., Thitithanyanont, A., Suphaphiphat, P., Essex, M., Kjems, J. & Lee, T-H., 26 Jan 2006, In: AIDS Research and Human Retroviruses. 22, 1, p. 76-82 7 p.

A microRNA detection system based on padlock probes and rolling circle amplification

Jonstrup, S. P., Koch, J. & Kjems, J., 2006, In: RNA. 12, 9, p. 1747-1752 6 p.

Dynamics of proviral HIV-1 184M/V in circulating CD4+ T-cells: a 90 days follow-up study after initiation/switch of HAART

Mohey, R., Katzenstein, T. L., Black, F. T., Kjems, J. & Obel, N., 2006, In: Scandinavian Journal of Infectious Diseases. 38, 2, p. 119-123 5 p.

Nanoparticles for nuclear acid delivery

Kjems, J., Liu, X., Howard, K. & Besenbacher, F., 2006

RNA interference in Vitro and in Vivo using a novel chitosan/siRNA nanoparticle system

Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. Ø., Hovgaard, M. B., Schmitz, A., Nyengaard, J. R., Besenbacher, F. & Kjems, J., 2006, In: Molecular Therapy. 14, 4, p. 476-484 9 p.

Single molecule FRET microscopy on G-quadruplex DNA structures

Birkedal, V., Krüger, A., Raarup, M. K., Kristensen, M., Kjems, J. & Besenbacher, F., 2006.

Single-molecule Microscopy on Nucleic Acids

Krüger, A., Birkedal, V., Raarup, M. K., Kristensen, M., Kjems, J. & Besenbacher, F., 2006.

Small internally segmented interfering RNA

Kjems, J. & Wengel, J., 2006

Småt blir' godt: Nanomedicin i fremtidens sundhedssektor

Olesen, J. R., Kjems, J. & Besenbacher, F., 2006, In: Lægen i Midten. 5, p. 31

Strategies to identify potential therapeutic target sites in RNA

Lützelberger, M. & Kjems, J., 2006, Handbook of Experimental Pharmacology: RNA Towards Medicine. Erdmann, V., Barciszewski, J. & Brosius, J. (eds.). Berlin: Springer, Vol. 173. p. 243-259 17 p.

Virus er naturens selviske nanorobotter

Andersen, E. S. & Kjems, J., 2006, Nanoteknologi: 12 historier om den nyeste danske forskning. Petersen, A-L. S. & Besenbacher, F. (eds.). Aarhus Universitet, p. 42-45 4 p.

Molecular strategies to inhibit HIV-1 replication

Nielsen, M. H., Pedersen, F. S. & Kjems, J., 16 Feb 2005, In: Retrovirology. 2, p. 10

In vitro Selection Strategy to Identify Antisense Target Sites in RNA or hnRNP Complexes: Application on HIV-1

Kjems, J., Jakobsen, M. R. & Lützelberger, M., 2005

Cantilever sensor for nanomechanical detection of specific protein conformations

Mukhopadhyay, R., Sumbayev, V. V., Lorentzen, M., Kjems, J., Andreasen, P. A. & Besenbacher, F., 2005, In: Nano Letters. 5, 12, p. 2385-8 4 p.

DNA-Directed Coupling of Organic Modules by Multiple Parallel Reductive Aminations and Subsequent Cleavage of Selected DNA Sequences

Nielsen, M., Dauksaite, V., Kjems, J. & Gothelf, K. V., 2005, In: Bioconjugate Chem.. 16, 4, p. 981-985 5 p.

Detection and quantification of proviral HIV-1 184 M/V in circulating CD4(+) T cells of patients on HAART with a viremia less than 1000 copies/ml

Mohey, R., Jørgensen, A. L., Møller, B. K., Black, F. T., Kjems, J. & Obel, N., 2005, In: Journal of Clinical Virology. 34, 4, p. 257-267 11 p.

HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain

Furnes, C., Arnesen, T., Askjaer, P., Kjems, J. & Szilvay, A. M., 2005, In: Retrovirology. 2, p. 39

Making implants last a lifetime

Kjems, J., Bünger, C., Nygaard, J. V. & Mygind, T., 2005, iNANO Annual Report 2005. University of Aarhus, p. 14-15 2 p.

Nanomechanical sensing of DNA sequences using piezoresistive cantilevers

Mukhopadhyay, R., Lorentzen, M., Kjems, J. & Besenbacher, F., 2005, In: Langmuir. 21, 18, p. 8400-8408 9 p.

SELEX Strategies to Identify Antisense and Protein Target Sites in RNA or Herogenous Nuclear Ribonucleoprotein Complexes

Lützelberger, M., Jakobsen, M. R., Kjems, J., Hartmann, R. K. (ed.), Schoen, A. (ed.) & Westhof, E. (ed.), 2005, Handbook of RNA Biochemistry. Weinheim: Wiley-VCH Verlag GmbH, p. 878-894 17 p.

Single-molecule FRET microscopy on DNA telomeres

Krüger, A., Bukowy, Z., Lutzelberger, M., Stevnsner, T., Kristensen, M., Kjems, J., Besenbacher, F. & Raarup, M. K., 2005.

Evolutionary rate variation and RNA secondary structure prediction

Knudsen, B., Andersen, E. S., Damgaard, C. K., Kjems, J. & Gorodkin, J., Jul 2004, In: Computational Biology and Chemistry. 28, 3, p. 219-26 8 p.

Role of the trans-activation response element in dimerization of HIV-1 RNA

Andersen, E. S., Contera, S. A., Knudsen, B., Damgaard, C. K., Besenbacher, F. & Kjems, J., 21 May 2004, In: Journal of Biological Chemistry. 279, 21, p. 22243-22249 7 p.

SC35 and heterogeneous nuclear ribonucleoprotein A/B proteins bind to a juxtaposed exonic splicing enhancer/exonic splicing silencer element to regulate HIV-1 tat exon 2 splicing

Zahler, A. M., Damgaard, C. K., Kjems, J. & Caputi, M., 12 Mar 2004, In: Journal of Biological Chemistry. 279, 11, p. 10077-10084 8 p.

RNA interactions in the 5' region of the HIV-1 genome

Damgaard, C. K., Andersen, E. S., Knudsen, B., Gorodkin, J. & Kjems, J., 13 Feb 2004, In: Journal of Molecular Biology. 336, 2, p. 369-79 11 p.

A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNA

Jakobsen, M. R., Damgaard, C. K., Andersen, E. S., Podhajska, A. & Kjems, J., 2004, In: Nucleic Acids Research. 32, 7, p. e67 10 p.

Analysis of Nanoparticles in Scaffolds for Tissue Engineering by use of X-Ray Nano Tomography

Nygaard, J. V., Andersen, M. Ø., Howard, K., Sasov, A., Kjems, J. & Besenbacher, F., 2004.

Case study: HIVs hemmelige sexliv

Andersen, E. S., Kjems, J., Thostrup, P. & Besenbacher, F., 2004, In: Biozoom. 7, 4, p. 23-25 3 p.

Role of the TAR hairpin in dimerization of HIV-1 RNA

Andersen, E. S., Contera, S., Knudsen, B., Damgaard, C. K., Besenbacher, F. & Kjems, J., 2004, In: Journal of Biological Chemistry. 279, p. 22243-22249 7 p.

SC35 and hnRNPs A/B binding to a juxtaposed ESE/ESS element regulates HIV-1 tat exon 2 splicing

Zahler, A. M., Damgaard, C. K., Kjems, J. & Caputi, M., 2004, In: Journal of Biological Chemistry. 279, p. 10077-10084 8 p.

A novel approach to describe a U1 snRNA binding site

Freund, M., Asang, C., Kammler, S., Konermann, C., Krummheuer, J., Hipp, M., Meyer, I., Gierling, W., Theiss, S., Preuss, T., Schindler, D., Kjems, J. & Schaal, H., 1 Dec 2003, In: Nucleic Acids Research. 31, 23, p. 6963-6975 13 p.

Dimerization and template switching in the 5' untranslated region between various subtypes of human immunodeficiency virus type 1

Andersen, E. S., Jeeninga, R. E., Damgaard, C. K., Berkhout, B. & Kjems, J., Mar 2003, In: Journal of Virology. 77, 5, p. 3020-30 11 p.

Biomolekyler visualiseret med scanning probe mikroskopi

Besenbacher, F., Kjems, J. & Andersen, E. S., 2003, Carlsberg Årsskrift 2003. p. 52-57 8 p.

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1

Köster, M., Lykke-Andersen, S., Elnakady, Y. A., Gerth, K., Washausen, P., Höfle, G., Sasse, F., Kjems, J. & Hauser, H., 2003, In: Experimental Cell Research. 286, 2, p. 321-331 11 p.

The 5′ splice site consensus: hydrogen bonding pattern or nucleotide frequency?

Freund, M., Kammler, S., Krummheuer, J., Hipp, M., Meyer, I., Gierling, W., Theiss, S., Preuss, T., Kjems, J. & Schaal, H., 2003, In: Nucl. Acid Res.. 31, p. 6963-6975 13 p.

The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation

Andersen, F. F., Tange, T. Ø., Sinnathamby, T., Lohmann, J. S., Andersen, K. E., Kjems, J., Westergaard, O. & Knudsen, B. R., 2003.

 A missense mutation found in patients with MCAD deficiency inactivates an exonic splicing enhancer in the MCAD gene

Nielsen, K. B., Sinnathamby, T., Cartegni, L., Corydon, T. J., Kjems, J., Krainer, A. R., Elpeleg, O., Gregersen, N. & Andresen, B. S., 2003.

A novel inhibitor of the CRM-1 mediated pathway

Daelemans, D., Afonina, E., Nilsson, J., Werner, G., Kjems, J., Clercq, E., Pavlakis, G. N. & Vandamme, A., 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, p. 14440-14445 6 p.

An element in the 3′untranslated region of human LINE-1 retrotransposon mRNA binds NXT1 (TAP) and can function as a nuclear export element

Lindtner, S., Felber, B. K. & Kjems, J., 2002, In: RNA. 8, p. 345-356 12 p.

Defining a 5′ splice site by functional selection in the presence and absence of U1 snRNA 5′-end

Lund, M. & Kjems, J., 2002, In: RNA. 8, p. 166-179 14 p.

Regulated HIV-2 RNA dimerization by means of alternative RNA conformation

Dirac, A. M., Huthoff, H., Kjems, J. & Berkhout, B., 2002, In: Nucleic Acids Research. 30, p. 2647-2655

Requirements for RNA-heterodimerization of the HIV-1 and HIV-2 genomes

A.M., D., H., H., Kjems, J. & B., B., 2002, In: Journal of General Virology. 83, p. 2533-2542 10 p.

The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form

Nilsson, J., Weis, K. & Kjems, J., 2002, In: J. Mol. Biol.. 318, p. 583-593 11 p.

The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation

Andersen, F. F., Tange, T. Ø., Sinnathamby, T., Olesen, J. R., Andersen, K. E., Westergaard, O., Kjems, J. & Knudsen, B. R., 2002, In: Journal of Molecular Biology.

hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure

Damgaard, C. K., Tange, T. Ø. & Kjems, J., 2002, In: RNA. 8

A role for the basic patch and the C-terminus of RanGTP in regulating the dynamic interaction with importin β, CRM1, and RanBP1

Nilsson, J., Askjaer, P. & Kjems, J., 2001, In: J. Mol. Biol.. 305, p. 231-243 13 p.

CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain

Poulsen, H., Nilsson, J., Damgaard, C. K., Jensen, J. E. & Kjems, J., 2001, In: Molecular and Cellular Biology. 21, p. 7862-7871 10 p.

Mapping DNA sites of HIV-1 integrase by protein footprinting

Dirac, A. G. & Kjems, J., 2001, In: F E B S Journal. 268, p. 743-751 9 p.

Repair of a Rev-minus HIV-1 mutant by activation of a cryptic splice site

Verhoef, K., Bilodeau, P. S., nullWamelJ.L.B., V., Kjems, J., Stoltzfus, C. M. & Berkhout, B., 2001, In: J. Virol.. 75, p. 3495-3500 6 p.

SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain

Tange, T. Ø. & Kjems, J., 2001, In: J. Mol. Biol.. 312, p. 649-662 14 p.

The DIS hairpin mediates dimerization of the HIV-2 RNA genome

Dirac, A. M., Huthoff, H., Kjems, J. & Berkhout, B., 2001, In: Journal of Biological Chemistry. 276, p. 32345-32352 8 p.

The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element

Tange, T. Ø., Damgaard, C. K., Guth, S., Valcárcel, J. & Kjems, J., 2001, In: E M B O Journal. 20, 20, p. 5748-5758 11 p.

The sequence complementarity of the HIV-1 5′ splice site SD4 and of U1 snRNA determines the steady-state level of an instable env pre-mRNA

Kammler, S., Leurs, C., Krummheuer, J., Seidel, K., Freund, M., Tange, T., Kjems, J., Scheid, A. & Schaal, H., 2001, In: RNA. 7, p. 421-434 14 p.

Characterization of human RNA splice signals by iterative functional selection of splice sites

Lund, M., Dyhr-Mikkelsen, H., Hansen, J. & Kjems, J., 2000, In: RNA. 6, p. 528-544 17 p.

HIV-1 Rev and its cellular partners

Kjems, J. & Askjær, P., 2000, In: Adv. in Pharmacol.. 48, p. 251-298 48 p.

Nuclear export of DEAD-box An3 protein by CRM1 is coupled to An3 helicase activity

Askjær, P., Rosendahl, R. & Kjems, J., 2000, In: Journal of Biological Chemistry. 275, p. 11657-11668 12 p.

RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase

Askjær, P., Bachi, A., Wilm, M., Bischoff, R., Weeks, D., Ohno, M., Kjems, J., Mattaj, I. & Fornerod, M., 1999, In: Molecular and Cellular Biology. 19, p. 6276-6285 10 p.

Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions

Damgaard, C. K., Dyhr-Mikkelsen, H. & Kjems, J., 15 Aug 1998, In: Nucleic Acid Research. 26, 16

Mapping metal ions at the catalytic centres of two intron-encoded endonucleases

Lykke-Andersen, J., Garrett, R. A. & Kjems, J., 1997, In: E M B O Journal. 16, 11, p. 3272-3281 10 p.

Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev

Kjems, J., Frankel, A. D. & Sharp, P. A., 1991, In: Cell. 67, 1, p. 169-178 10 p.