Jørgen Frøkiær

Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders

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Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders. / Graugaard-Jensen, Charlotte; Hvistendahl, Gitte M; Frøkiaer, Jørgen; Bie, Peter; Djurhuus, Jens Christian.

In: Acta Physiologica (Online), 26.06.2014.

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@article{2f94f9ee7dae4b949a5afebe2bc9cbb8,
title = "Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders",
abstract = "AIM: We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.METHODS: Fifteen young women in mid-follicular phase and 22 young men (20-33 y) were included. All participants underwent a 24-h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin-2 and prostaglandin E2.RESULTS: Plasma vasopressin expressed a diurnal rhythm with a nighttime increase in both genders (p<0.001). The ratio between mean daytime and mean nighttime was 1.57 [95% conf. interval: 1.33-1.84] p<0.001 in men, and 1.35 [95% conf. interval: 1.11-1.64] p=0.002 in women. P-vasopressin was higher in males during the night (p<0.05). There was no difference in diuresis (p=0.43), urine osmolality (p=0.12) or aquaporin 2-excretion (p=0.80) between genders. We found a trend towards a higher reabsorption of free water in males (p=0.07). The excretion of prostaglandin E2 was higher in males (p<0.001). There was no diurnal rhythm in p-oxytocin (p=0.37) and no correlation to diuresis, urine osmolality or aquaporin-2 excretions.CONCLUSION: Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation. This article is protected by copyright. All rights reserved.",
author = "Charlotte Graugaard-Jensen and Hvistendahl, {Gitte M} and J{\o}rgen Fr{\o}kiaer and Peter Bie and Djurhuus, {Jens Christian}",
note = "This article is protected by copyright. All rights reserved.",
year = "2014",
month = jun,
day = "26",
doi = "10.1111/apha.12337",
language = "English",
journal = "Acta Physiologica (Print)",
issn = "1748-1708",
publisher = "Wiley-Blackwell Publishing Ltd.",

}

RIS

TY - JOUR

T1 - Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders

AU - Graugaard-Jensen, Charlotte

AU - Hvistendahl, Gitte M

AU - Frøkiaer, Jørgen

AU - Bie, Peter

AU - Djurhuus, Jens Christian

N1 - This article is protected by copyright. All rights reserved.

PY - 2014/6/26

Y1 - 2014/6/26

N2 - AIM: We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.METHODS: Fifteen young women in mid-follicular phase and 22 young men (20-33 y) were included. All participants underwent a 24-h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin-2 and prostaglandin E2.RESULTS: Plasma vasopressin expressed a diurnal rhythm with a nighttime increase in both genders (p<0.001). The ratio between mean daytime and mean nighttime was 1.57 [95% conf. interval: 1.33-1.84] p<0.001 in men, and 1.35 [95% conf. interval: 1.11-1.64] p=0.002 in women. P-vasopressin was higher in males during the night (p<0.05). There was no difference in diuresis (p=0.43), urine osmolality (p=0.12) or aquaporin 2-excretion (p=0.80) between genders. We found a trend towards a higher reabsorption of free water in males (p=0.07). The excretion of prostaglandin E2 was higher in males (p<0.001). There was no diurnal rhythm in p-oxytocin (p=0.37) and no correlation to diuresis, urine osmolality or aquaporin-2 excretions.CONCLUSION: Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation. This article is protected by copyright. All rights reserved.

AB - AIM: We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.METHODS: Fifteen young women in mid-follicular phase and 22 young men (20-33 y) were included. All participants underwent a 24-h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin-2 and prostaglandin E2.RESULTS: Plasma vasopressin expressed a diurnal rhythm with a nighttime increase in both genders (p<0.001). The ratio between mean daytime and mean nighttime was 1.57 [95% conf. interval: 1.33-1.84] p<0.001 in men, and 1.35 [95% conf. interval: 1.11-1.64] p=0.002 in women. P-vasopressin was higher in males during the night (p<0.05). There was no difference in diuresis (p=0.43), urine osmolality (p=0.12) or aquaporin 2-excretion (p=0.80) between genders. We found a trend towards a higher reabsorption of free water in males (p=0.07). The excretion of prostaglandin E2 was higher in males (p<0.001). There was no diurnal rhythm in p-oxytocin (p=0.37) and no correlation to diuresis, urine osmolality or aquaporin-2 excretions.CONCLUSION: Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation. This article is protected by copyright. All rights reserved.

U2 - 10.1111/apha.12337

DO - 10.1111/apha.12337

M3 - Journal article

C2 - 24965868

JO - Acta Physiologica (Print)

JF - Acta Physiologica (Print)

SN - 1748-1708

ER -