Jørgen Frøkiær

Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis. / Madsen, Mia Gebauer; Nørregaard, Rikke; Frøkiær, Jørgen et al.

In: Journal of Pediatric Urology, Vol. 7, No. 2, 08.01.2011, p. 105-112.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Madsen, MG, Nørregaard, R, Frøkiær, J & Jørgensen, TM 2011, 'Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis', Journal of Pediatric Urology, vol. 7, no. 2, pp. 105-112. https://doi.org/10.1016/j.jpurol.2010.12.004

APA

CBE

MLA

Madsen, Mia Gebauer et al. "Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis". Journal of Pediatric Urology. 2011, 7(2). 105-112. https://doi.org/10.1016/j.jpurol.2010.12.004

Vancouver

Author

Madsen, Mia Gebauer ; Nørregaard, Rikke ; Frøkiær, Jørgen et al. / Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis. In: Journal of Pediatric Urology. 2011 ; Vol. 7, No. 2. pp. 105-112.

Bibtex

@article{a315508a972a45b5b7df35c1bd644df3,
title = "Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis",
abstract = "The introduction of prenatal ultrasonography as a screening method entails an increasing number of infants diagnosed with prenatal hydronephrosis. Ureteropelvic junction obstruction accounts for 35% of prenatal hydronephrotic cases. Urinary tract obstruction that occurs during early kidney development affects renal morphogenesis, maturation and growth, and in the most severe cases this will ultimately cause renal insufficiency. A major challenge in the clinical management of these patients is to preserve renal function by selection of the 15%-20% who require early surgical intervention, leaving those for whom watchful waiting may be appropriate because of spontaneous resolution/stabilization without significant loss of renal function. Today, this requires medical surveillance, including repetitive invasive diuretic renograms relying on arbitrary threshold values, and therefore there is a need for non-arbitrary, non-invasive urinary biomarkers that may be used as predictors for renal structural changes and/or decreasing renal function, and thereby provide the surgeon with more clear indications for surgical intervention. In this review, we summarize the currently well-known facts about urinary biomarkers in ureteropelvic junction obstruction concerning renal function, and we also suggest potential novel urinary biomarkers.",
author = "Madsen, {Mia Gebauer} and Rikke N{\o}rregaard and J{\o}rgen Fr{\o}ki{\ae}r and J{\o}rgensen, {Troels Munch}",
note = "Copyright {\^A}{\textcopyright} 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.",
year = "2011",
month = jan,
day = "8",
doi = "10.1016/j.jpurol.2010.12.004",
language = "English",
volume = "7",
pages = "105--112",
journal = "Journal of Pediatric Urology",
issn = "1477-5131",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis

AU - Madsen, Mia Gebauer

AU - Nørregaard, Rikke

AU - Frøkiær, Jørgen

AU - Jørgensen, Troels Munch

N1 - Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

PY - 2011/1/8

Y1 - 2011/1/8

N2 - The introduction of prenatal ultrasonography as a screening method entails an increasing number of infants diagnosed with prenatal hydronephrosis. Ureteropelvic junction obstruction accounts for 35% of prenatal hydronephrotic cases. Urinary tract obstruction that occurs during early kidney development affects renal morphogenesis, maturation and growth, and in the most severe cases this will ultimately cause renal insufficiency. A major challenge in the clinical management of these patients is to preserve renal function by selection of the 15%-20% who require early surgical intervention, leaving those for whom watchful waiting may be appropriate because of spontaneous resolution/stabilization without significant loss of renal function. Today, this requires medical surveillance, including repetitive invasive diuretic renograms relying on arbitrary threshold values, and therefore there is a need for non-arbitrary, non-invasive urinary biomarkers that may be used as predictors for renal structural changes and/or decreasing renal function, and thereby provide the surgeon with more clear indications for surgical intervention. In this review, we summarize the currently well-known facts about urinary biomarkers in ureteropelvic junction obstruction concerning renal function, and we also suggest potential novel urinary biomarkers.

AB - The introduction of prenatal ultrasonography as a screening method entails an increasing number of infants diagnosed with prenatal hydronephrosis. Ureteropelvic junction obstruction accounts for 35% of prenatal hydronephrotic cases. Urinary tract obstruction that occurs during early kidney development affects renal morphogenesis, maturation and growth, and in the most severe cases this will ultimately cause renal insufficiency. A major challenge in the clinical management of these patients is to preserve renal function by selection of the 15%-20% who require early surgical intervention, leaving those for whom watchful waiting may be appropriate because of spontaneous resolution/stabilization without significant loss of renal function. Today, this requires medical surveillance, including repetitive invasive diuretic renograms relying on arbitrary threshold values, and therefore there is a need for non-arbitrary, non-invasive urinary biomarkers that may be used as predictors for renal structural changes and/or decreasing renal function, and thereby provide the surgeon with more clear indications for surgical intervention. In this review, we summarize the currently well-known facts about urinary biomarkers in ureteropelvic junction obstruction concerning renal function, and we also suggest potential novel urinary biomarkers.

U2 - 10.1016/j.jpurol.2010.12.004

DO - 10.1016/j.jpurol.2010.12.004

M3 - Journal article

C2 - 21220211

VL - 7

SP - 105

EP - 112

JO - Journal of Pediatric Urology

JF - Journal of Pediatric Urology

SN - 1477-5131

IS - 2

ER -