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Jørgen Frøkiær

RubiShort: Reducing scan time in 82Rb heart scans to minimize movements artifacts

Research output: Contribution to conferencePosterResearchpeer-review

Aim: Relative and absolute myocardial blood flow (MBF) can derived from a single 82Rb PET/CT scan using list mode data to extract both static and dynamic PET series. However, patient movement and changes in breathing pattern, especially during pharmacological stress, reduce the quality of the scans and are known to introduce artifacts in 10-15% of all scans. By reducing scan time from 7 min. to 5 min, we expect to reduce the frequency of motion artifacts. This is, however, at the cost of information used for MBF calculation and count statistics in the relative blood flow images. We set out to examine if a reduction of scan time would affect the accuracy of the examination. Method: Both stress and rest 82Rb scans from 11 random clinical patients without motion artifacts were selected. Using list mode data, dynamic series from 0-7 min (standard) and 0-5 min (short) after 82Rb infusion as well as static series from 2.5-7 min (standard) and 2.5-5 min (short) after 82Rb infusion were reconstructed. Data was analyzed using QPET (Cedar Sinai). Absolute (MBF, 17-segment AHA-model) and relative (%Extend, %Reversible and Total Perfusion Deficit (TPD), 5 segments) parameters were compared by using scatter plots and linear regression. Results: Excellent correlation between the 7 min. and 5 min. data was found for absolute MBF (y=1.014x, R2=0.98). For all relative parameters obtained from the static reconstructions, excellent correlation was likewise observed between 7 min. and 5 min. reconstructions (%Extent: y=1.013x, R2=0.98; %Reversible: y=1.008x, R2=0.95; TPD: y=1.000x, R2=0.99). Conclusion:, Scan time of myocardial perfusion scans using 82Rb can be reduced from 7 min. to 5 min. without loss of quantitative accuracy. Since patient motion is frequent in the last minutes of the scans, scan time reduction is likely to reduce motion artifacts.
Original languageEnglish
Publication year10 Oct 2015
DOIs
Publication statusPublished - 10 Oct 2015
EventEANM'15 - Hamborg, Hamborg, Germany
Duration: 11 Oct 201514 Oct 2015

Conference

ConferenceEANM'15
LocationHamborg
CountryGermany
CityHamborg
Period11/10/201514/10/2015

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