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Jørgen Frøkiær

Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate

Research output: Contribution to conferencePosterResearch

Standard

Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate. / Andersen, Trine Borup; Jødal, Lars; Bøgsted, Martin; J. Erlandsen, Erland; Eskild-Jensen, Anni; Frøkiær, Jørgen; Brøchner-Mortensen, Jens.

2010. Poster session presented at Forskningens Dag 2010, Aalborg, Denmark.

Research output: Contribution to conferencePosterResearch

Harvard

Andersen, TB, Jødal, L, Bøgsted, M, J. Erlandsen, E, Eskild-Jensen, A, Frøkiær, J & Brøchner-Mortensen, J 2010, 'Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate', Forskningens Dag 2010, Aalborg, Denmark, 28/10/2010 - 28/10/2010.

APA

Andersen, T. B., Jødal, L., Bøgsted, M., J. Erlandsen, E., Eskild-Jensen, A., Frøkiær, J., & Brøchner-Mortensen, J. (2010). Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate. Poster session presented at Forskningens Dag 2010, Aalborg, Denmark.

CBE

Andersen TB, Jødal L, Bøgsted M, J. Erlandsen E, Eskild-Jensen A, Frøkiær J, Brøchner-Mortensen J. 2010. Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate. Poster session presented at Forskningens Dag 2010, Aalborg, Denmark.

MLA

Andersen, Trine Borup et al. Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate. Forskningens Dag 2010, 28 Oct 2010, Aalborg, Denmark, Poster, 2010.

Vancouver

Andersen TB, Jødal L, Bøgsted M, J. Erlandsen E, Eskild-Jensen A, Frøkiær J et al. Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate. 2010. Poster session presented at Forskningens Dag 2010, Aalborg, Denmark.

Author

Andersen, Trine Borup ; Jødal, Lars ; Bøgsted, Martin ; J. Erlandsen, Erland ; Eskild-Jensen, Anni ; Frøkiær, Jørgen ; Brøchner-Mortensen, Jens. / Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate. Poster session presented at Forskningens Dag 2010, Aalborg, Denmark.

Bibtex

@conference{a0c9dd70f6e211dfa891000ea68e967b,
title = "Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate",
abstract = "AIM: To derive an accurate prediction model for estimating glomerular filtration rate (GFR) in children based primarily on the endogenous renal function marker cystatin C (CysC) and body cell mass (BCM).THEORY: Cystatin C is produced at a constant rate in all cells of the body and is excreted by glomerular filtration followed by catabolization in the tubular cells. We hypothesized that production rate is proportional to body cell mass (BCM) and inferred GFR (mL/min) to be proportional to BCM/CysC.MATERIAL AND METHODS: GFR was determined with 51Cr-EDTA-clearance in 131 children (52 girls, 79 boys) aged 2-14 years. GFR was 14-147 mL/min/1.73m2. BCM was estimated using bioimpedance spectroscopy. Log-transformed data on BCM/CysC, serum creatinine (SCr), body-surface-area (BSA), height×BSA/SCr, CysC, weight, sex, age, height, serum urea and albumin were considered possible explanatory variables using robust regression in a forward, stepwise procedure. GFR (mL/min) was the dependent variable. The accuracy and precision of the prediction model were compared to other prediction models from the literature, using k-fold cross-validation. Local constants and coefficients were calculated for all models. RESULTS: New prediction equation GFR (mL/min) = (BCM/CysC)^0.39×(heightxBSA/SCr)^0.65×10.2 could predict 99% within ±30% of reference GFR, and 66% within ±10%. This was higher than all other equations. The present equation also had the highest R2 and the narrowest 95% limits of agreement.CONCLUSION: The new equation predicts GFR with higher accuracy than other equations. Endogenous methods are, however, still not accurate enough to replace exogenous markers when GFR must be determined with high accuracy.",
keywords = "Cystatin C, Glomerular filtrationsrate, Bioelectric impedance spectroscopy, Cystatin C, Glomerular Filtration Rate, Bioelectric impedance spectroscopy",
author = "Andersen, {Trine Borup} and Lars J{\o}dal and Martin B{\o}gsted and {J. Erlandsen}, Erland and Anni Eskild-Jensen and J{\o}rgen Fr{\o}ki{\ae}r and Jens Br{\o}chner-Mortensen",
year = "2010",
language = "English",
note = "null ; Conference date: 28-10-2010 Through 28-10-2010",

}

RIS

TY - CONF

T1 - Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate

AU - Andersen, Trine Borup

AU - Jødal, Lars

AU - Bøgsted, Martin

AU - J. Erlandsen, Erland

AU - Eskild-Jensen, Anni

AU - Frøkiær, Jørgen

AU - Brøchner-Mortensen, Jens

PY - 2010

Y1 - 2010

N2 - AIM: To derive an accurate prediction model for estimating glomerular filtration rate (GFR) in children based primarily on the endogenous renal function marker cystatin C (CysC) and body cell mass (BCM).THEORY: Cystatin C is produced at a constant rate in all cells of the body and is excreted by glomerular filtration followed by catabolization in the tubular cells. We hypothesized that production rate is proportional to body cell mass (BCM) and inferred GFR (mL/min) to be proportional to BCM/CysC.MATERIAL AND METHODS: GFR was determined with 51Cr-EDTA-clearance in 131 children (52 girls, 79 boys) aged 2-14 years. GFR was 14-147 mL/min/1.73m2. BCM was estimated using bioimpedance spectroscopy. Log-transformed data on BCM/CysC, serum creatinine (SCr), body-surface-area (BSA), height×BSA/SCr, CysC, weight, sex, age, height, serum urea and albumin were considered possible explanatory variables using robust regression in a forward, stepwise procedure. GFR (mL/min) was the dependent variable. The accuracy and precision of the prediction model were compared to other prediction models from the literature, using k-fold cross-validation. Local constants and coefficients were calculated for all models. RESULTS: New prediction equation GFR (mL/min) = (BCM/CysC)^0.39×(heightxBSA/SCr)^0.65×10.2 could predict 99% within ±30% of reference GFR, and 66% within ±10%. This was higher than all other equations. The present equation also had the highest R2 and the narrowest 95% limits of agreement.CONCLUSION: The new equation predicts GFR with higher accuracy than other equations. Endogenous methods are, however, still not accurate enough to replace exogenous markers when GFR must be determined with high accuracy.

AB - AIM: To derive an accurate prediction model for estimating glomerular filtration rate (GFR) in children based primarily on the endogenous renal function marker cystatin C (CysC) and body cell mass (BCM).THEORY: Cystatin C is produced at a constant rate in all cells of the body and is excreted by glomerular filtration followed by catabolization in the tubular cells. We hypothesized that production rate is proportional to body cell mass (BCM) and inferred GFR (mL/min) to be proportional to BCM/CysC.MATERIAL AND METHODS: GFR was determined with 51Cr-EDTA-clearance in 131 children (52 girls, 79 boys) aged 2-14 years. GFR was 14-147 mL/min/1.73m2. BCM was estimated using bioimpedance spectroscopy. Log-transformed data on BCM/CysC, serum creatinine (SCr), body-surface-area (BSA), height×BSA/SCr, CysC, weight, sex, age, height, serum urea and albumin were considered possible explanatory variables using robust regression in a forward, stepwise procedure. GFR (mL/min) was the dependent variable. The accuracy and precision of the prediction model were compared to other prediction models from the literature, using k-fold cross-validation. Local constants and coefficients were calculated for all models. RESULTS: New prediction equation GFR (mL/min) = (BCM/CysC)^0.39×(heightxBSA/SCr)^0.65×10.2 could predict 99% within ±30% of reference GFR, and 66% within ±10%. This was higher than all other equations. The present equation also had the highest R2 and the narrowest 95% limits of agreement.CONCLUSION: The new equation predicts GFR with higher accuracy than other equations. Endogenous methods are, however, still not accurate enough to replace exogenous markers when GFR must be determined with high accuracy.

KW - Cystatin C

KW - Glomerular filtrationsrate

KW - Bioelectric impedance spectroscopy

KW - Cystatin C

KW - Glomerular Filtration Rate

KW - Bioelectric impedance spectroscopy

M3 - Poster

Y2 - 28 October 2010 through 28 October 2010

ER -