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Jørgen Frøkiær

Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney

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Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. / Nørregaard, Rikke; Kwon, Tae-Hwan; Frøkiær, Jørgen.

In: Kidney Research and Clinical Pratice, Vol. 34, No. 4, 12.2015, p. 194-200.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

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Nørregaard, Rikke ; Kwon, Tae-Hwan ; Frøkiær, Jørgen. / Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. In: Kidney Research and Clinical Pratice. 2015 ; Vol. 34, No. 4. pp. 194-200.

Bibtex

@article{15ecf9de2f2f45bab86ad58acb3bfe3c,
title = "Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney",
abstract = "The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological processes in the kidney, including renal hemodynamics, body water and sodium balance, and the inflammatory injury characteristic in multiple renal diseases. Since the beginning of 1990s, it has been confirmed that COX exists in 2 isoforms, referred to as COX-1 and COX-2. Even though the 2 enzymes are similar in size and structure, COX-1 and COX-2 are regulated by different systems and have different functional roles. This review summarizes the current data on renal expression of the 2 COX isoforms and highlights mainly the role of COX-2 and PGE2 in several physiological and pathophysiological processes in the kidney.",
keywords = "Journal Article, Review",
author = "Rikke N{\o}rregaard and Tae-Hwan Kwon and J{\o}rgen Fr{\o}ki{\ae}r",
year = "2015",
month = dec,
doi = "10.1016/j.krcp.2015.10.004",
language = "English",
volume = "34",
pages = "194--200",
journal = "Kidney Research and Clinical Pratice",
issn = "1975-9460",
number = "4",

}

RIS

TY - JOUR

T1 - Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney

AU - Nørregaard, Rikke

AU - Kwon, Tae-Hwan

AU - Frøkiær, Jørgen

PY - 2015/12

Y1 - 2015/12

N2 - The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological processes in the kidney, including renal hemodynamics, body water and sodium balance, and the inflammatory injury characteristic in multiple renal diseases. Since the beginning of 1990s, it has been confirmed that COX exists in 2 isoforms, referred to as COX-1 and COX-2. Even though the 2 enzymes are similar in size and structure, COX-1 and COX-2 are regulated by different systems and have different functional roles. This review summarizes the current data on renal expression of the 2 COX isoforms and highlights mainly the role of COX-2 and PGE2 in several physiological and pathophysiological processes in the kidney.

AB - The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological processes in the kidney, including renal hemodynamics, body water and sodium balance, and the inflammatory injury characteristic in multiple renal diseases. Since the beginning of 1990s, it has been confirmed that COX exists in 2 isoforms, referred to as COX-1 and COX-2. Even though the 2 enzymes are similar in size and structure, COX-1 and COX-2 are regulated by different systems and have different functional roles. This review summarizes the current data on renal expression of the 2 COX isoforms and highlights mainly the role of COX-2 and PGE2 in several physiological and pathophysiological processes in the kidney.

KW - Journal Article

KW - Review

U2 - 10.1016/j.krcp.2015.10.004

DO - 10.1016/j.krcp.2015.10.004

M3 - Review

C2 - 26779421

VL - 34

SP - 194

EP - 200

JO - Kidney Research and Clinical Pratice

JF - Kidney Research and Clinical Pratice

SN - 1975-9460

IS - 4

ER -