Jørgen Frøkiær

Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets.

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Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets. / Dissing, Thomas; Eskild-Jensen, Anni; Pagh, Christian; Frøkiær, Jørgen; Rehling, Michael; Stødkilde-Jørgensen, Hans; Jørgensen, Troels Munk; Djurhuus, Jens Christian.

In: Journal of Urology, Vol. 166, No. 6, 2001, p. 2354-8.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

Dissing T, Eskild-Jensen A, Pagh C, Frøkiær J, Rehling M, Stødkilde-Jørgensen H, Jørgensen TM, Djurhuus JC. 2001. Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets. Journal of Urology. 166(6):2354-8.

MLA

Dissing, Thomas et al. "Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets.". Journal of Urology. 2001, 166(6). 2354-8.

Vancouver

Dissing T, Eskild-Jensen A, Pagh C, Frøkiær J, Rehling M, Stødkilde-Jørgensen H et al. Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets. Journal of Urology. 2001;166(6):2354-8.

Author

Dissing, Thomas ; Eskild-Jensen, Anni ; Pagh, Christian ; Frøkiær, Jørgen ; Rehling, Michael ; Stødkilde-Jørgensen, Hans ; Jørgensen, Troels Munk ; Djurhuus, Jens Christian. / Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets. In: Journal of Urology. 2001 ; Vol. 166, No. 6. pp. 2354-8.

Bibtex

@article{05d67f70668111dcbee902004c4f4f50,
title = "Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets.",
abstract = "PURPOSE: We examined effects on kidney function and morphology of a partial ureteropelvic junction obstruction induced late in the postnatal nephrogenesis period of the pig. We compared the results to a similar study on pigs with obstruction induced early in the nephrogenesis period. MATERIALS AND METHODS: A total of 20 14-day-old pigs were included in the study. Fifteen animals were randomized to partial unilateral obstruction and 5 were sham operated. Kidney function and morphology were analyzed regarding glomerular filtration rate, renographic functional share and total kidney volume at the age of 4, 12 and 24 weeks. RESULTS: At age 4 weeks hydronephrosis was found in all obstructed kidneys included in the study. Four obstructed kidneys had renographic functional share 40% or greater and 1 deteriorated to less than 40% at 24 weeks. A total of 11 obstructed kidneys had a functional share less than 40%, 5 increased to a share greater than 40% at age 24 weeks and 3 had decreasing share from age 4 to 24 weeks. Single kidney glomerular filtration rate of the contralateral kidneys was significantly increased at all ages. Volume of the contralateral kidney was significantly increased at age 4 and 12 weeks. CONCLUSIONS: The variability and course of renographic functional share in kidneys subjected to partial obstruction at age 2 weeks was similar to findings obtained in pigs obstructed at age 2 days. In contrast to these our study showed compensatory increase in function and size of the contralateral kidney, suggesting that contralateral compensation is an ability gained late in the nephrogenesis period.",
author = "Thomas Dissing and Anni Eskild-Jensen and Christian Pagh and J{\o}rgen Fr{\o}ki{\ae}r and Michael Rehling and Hans St{\o}dkilde-J{\o}rgensen and J{\o}rgensen, {Troels Munk} and Djurhuus, {Jens Christian}",
year = "2001",
language = "English",
volume = "166",
pages = "2354--8",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets.

AU - Dissing, Thomas

AU - Eskild-Jensen, Anni

AU - Pagh, Christian

AU - Frøkiær, Jørgen

AU - Rehling, Michael

AU - Stødkilde-Jørgensen, Hans

AU - Jørgensen, Troels Munk

AU - Djurhuus, Jens Christian

PY - 2001

Y1 - 2001

N2 - PURPOSE: We examined effects on kidney function and morphology of a partial ureteropelvic junction obstruction induced late in the postnatal nephrogenesis period of the pig. We compared the results to a similar study on pigs with obstruction induced early in the nephrogenesis period. MATERIALS AND METHODS: A total of 20 14-day-old pigs were included in the study. Fifteen animals were randomized to partial unilateral obstruction and 5 were sham operated. Kidney function and morphology were analyzed regarding glomerular filtration rate, renographic functional share and total kidney volume at the age of 4, 12 and 24 weeks. RESULTS: At age 4 weeks hydronephrosis was found in all obstructed kidneys included in the study. Four obstructed kidneys had renographic functional share 40% or greater and 1 deteriorated to less than 40% at 24 weeks. A total of 11 obstructed kidneys had a functional share less than 40%, 5 increased to a share greater than 40% at age 24 weeks and 3 had decreasing share from age 4 to 24 weeks. Single kidney glomerular filtration rate of the contralateral kidneys was significantly increased at all ages. Volume of the contralateral kidney was significantly increased at age 4 and 12 weeks. CONCLUSIONS: The variability and course of renographic functional share in kidneys subjected to partial obstruction at age 2 weeks was similar to findings obtained in pigs obstructed at age 2 days. In contrast to these our study showed compensatory increase in function and size of the contralateral kidney, suggesting that contralateral compensation is an ability gained late in the nephrogenesis period.

AB - PURPOSE: We examined effects on kidney function and morphology of a partial ureteropelvic junction obstruction induced late in the postnatal nephrogenesis period of the pig. We compared the results to a similar study on pigs with obstruction induced early in the nephrogenesis period. MATERIALS AND METHODS: A total of 20 14-day-old pigs were included in the study. Fifteen animals were randomized to partial unilateral obstruction and 5 were sham operated. Kidney function and morphology were analyzed regarding glomerular filtration rate, renographic functional share and total kidney volume at the age of 4, 12 and 24 weeks. RESULTS: At age 4 weeks hydronephrosis was found in all obstructed kidneys included in the study. Four obstructed kidneys had renographic functional share 40% or greater and 1 deteriorated to less than 40% at 24 weeks. A total of 11 obstructed kidneys had a functional share less than 40%, 5 increased to a share greater than 40% at age 24 weeks and 3 had decreasing share from age 4 to 24 weeks. Single kidney glomerular filtration rate of the contralateral kidneys was significantly increased at all ages. Volume of the contralateral kidney was significantly increased at age 4 and 12 weeks. CONCLUSIONS: The variability and course of renographic functional share in kidneys subjected to partial obstruction at age 2 weeks was similar to findings obtained in pigs obstructed at age 2 days. In contrast to these our study showed compensatory increase in function and size of the contralateral kidney, suggesting that contralateral compensation is an ability gained late in the nephrogenesis period.

M3 - Journal article

VL - 166

SP - 2354

EP - 2358

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -