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Jørgen Frøkiær

Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats

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Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats. / O'Neill, Heidi A; Kwon, Tae-Hwan; Ring, Troels; Dimke, Henrik Anthony; Lebeck, Janne; Frøkiaer, Jørgen; Collins, Patrick B; Nielsen, Søren; Frische, Sebastian.

In: Acta Physiologica (Print), Vol. 202, No. 1, 14.03.2011, p. 47-57.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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O'Neill, HA, Kwon, T-H, Ring, T, Dimke, HA, Lebeck, J, Frøkiaer, J, Collins, PB, Nielsen, S & Frische, S 2011, 'Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats', Acta Physiologica (Print), vol. 202, no. 1, pp. 47-57. https://doi.org/10.1111/j.1748-1716.2011.02260.x

APA

O'Neill, H. A., Kwon, T-H., Ring, T., Dimke, H. A., Lebeck, J., Frøkiaer, J., Collins, P. B., Nielsen, S., & Frische, S. (2011). Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats. Acta Physiologica (Print), 202(1), 47-57. https://doi.org/10.1111/j.1748-1716.2011.02260.x

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O'Neill, Heidi A ; Kwon, Tae-Hwan ; Ring, Troels ; Dimke, Henrik Anthony ; Lebeck, Janne ; Frøkiaer, Jørgen ; Collins, Patrick B ; Nielsen, Søren ; Frische, Sebastian. / Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats. In: Acta Physiologica (Print). 2011 ; Vol. 202, No. 1. pp. 47-57.

Bibtex

@article{0e2d588695e54c8d9e258d4fee0adc30,
title = "Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats",
abstract = "Aim:  To test the effects of dietary NaCl and carbohydrate content on urine volume in diabetic rats. Methods:  Streptozotocin-induced diabetic rats were subjected to NaCl-restriction using either a NaCl-deficient carbohydrate-rich synthetic diet (Altromin C1036) supplemented to contain 0.16% NaCl (C1036+lowNaCl) or a modified normal cereal based diet (Altromin 1320) containing 0.086 NaCl (lowNaCl-1320). Normal diet contained 0.2683% NaCl. Results:  Using the C1036+lowNaCl diet, earlier reported paradoxical increases in water intake and urine volume of diabetic rats were reproduced. However, water intake and urine volume also increased in diabetic rats offered the synthetic C1036 diet supplemented with NaCl to normal levels. Using the lowNaCl-1320 diet, water intake and urine volume were markedly reduced. Highly significant correlations between urine volume and both osmotic output and urinary glucose excretion were found in diabetic rats on normal diet, but these correlations were absent in diabetic rats on synthetic diet, which showed higher urine volumes than expected from the correlations. In contrast, urine volume was significantly correlated with carbohydrate intake in diabetic rats, irrespective of the diet. Conclusions:  1) The synthetic diet dramatically increases the urine volume in STZ-DM rats irrespectively of NaCl-content. 2) Rats with STZ-DM on a normal diet show reduced water intake and urine volume in response to dietary NaCl restriction. 3) A shift to high carbohydrate diet induces polyuria in STZ-DM rats. 4) Urine volume in all STZ-DM rats only shows correlation with with dietary carbohydrate intake. 5) Glucose-driven osmotic diuresis is unlike to explain the carbohydrate-induced polyuria.",
author = "O'Neill, {Heidi A} and Tae-Hwan Kwon and Troels Ring and Dimke, {Henrik Anthony} and Janne Lebeck and J{\o}rgen Fr{\o}kiaer and Collins, {Patrick B} and S{\o}ren Nielsen and Sebastian Frische",
note = "Copyright {\textcopyright} 2011 Scandinavian Physiological Society.",
year = "2011",
month = mar,
day = "14",
doi = "10.1111/j.1748-1716.2011.02260.x",
language = "English",
volume = "202",
pages = "47--57",
journal = "Acta Physiologica (Print)",
issn = "1748-1708",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats

AU - O'Neill, Heidi A

AU - Kwon, Tae-Hwan

AU - Ring, Troels

AU - Dimke, Henrik Anthony

AU - Lebeck, Janne

AU - Frøkiaer, Jørgen

AU - Collins, Patrick B

AU - Nielsen, Søren

AU - Frische, Sebastian

N1 - Copyright © 2011 Scandinavian Physiological Society.

PY - 2011/3/14

Y1 - 2011/3/14

N2 - Aim:  To test the effects of dietary NaCl and carbohydrate content on urine volume in diabetic rats. Methods:  Streptozotocin-induced diabetic rats were subjected to NaCl-restriction using either a NaCl-deficient carbohydrate-rich synthetic diet (Altromin C1036) supplemented to contain 0.16% NaCl (C1036+lowNaCl) or a modified normal cereal based diet (Altromin 1320) containing 0.086 NaCl (lowNaCl-1320). Normal diet contained 0.2683% NaCl. Results:  Using the C1036+lowNaCl diet, earlier reported paradoxical increases in water intake and urine volume of diabetic rats were reproduced. However, water intake and urine volume also increased in diabetic rats offered the synthetic C1036 diet supplemented with NaCl to normal levels. Using the lowNaCl-1320 diet, water intake and urine volume were markedly reduced. Highly significant correlations between urine volume and both osmotic output and urinary glucose excretion were found in diabetic rats on normal diet, but these correlations were absent in diabetic rats on synthetic diet, which showed higher urine volumes than expected from the correlations. In contrast, urine volume was significantly correlated with carbohydrate intake in diabetic rats, irrespective of the diet. Conclusions:  1) The synthetic diet dramatically increases the urine volume in STZ-DM rats irrespectively of NaCl-content. 2) Rats with STZ-DM on a normal diet show reduced water intake and urine volume in response to dietary NaCl restriction. 3) A shift to high carbohydrate diet induces polyuria in STZ-DM rats. 4) Urine volume in all STZ-DM rats only shows correlation with with dietary carbohydrate intake. 5) Glucose-driven osmotic diuresis is unlike to explain the carbohydrate-induced polyuria.

AB - Aim:  To test the effects of dietary NaCl and carbohydrate content on urine volume in diabetic rats. Methods:  Streptozotocin-induced diabetic rats were subjected to NaCl-restriction using either a NaCl-deficient carbohydrate-rich synthetic diet (Altromin C1036) supplemented to contain 0.16% NaCl (C1036+lowNaCl) or a modified normal cereal based diet (Altromin 1320) containing 0.086 NaCl (lowNaCl-1320). Normal diet contained 0.2683% NaCl. Results:  Using the C1036+lowNaCl diet, earlier reported paradoxical increases in water intake and urine volume of diabetic rats were reproduced. However, water intake and urine volume also increased in diabetic rats offered the synthetic C1036 diet supplemented with NaCl to normal levels. Using the lowNaCl-1320 diet, water intake and urine volume were markedly reduced. Highly significant correlations between urine volume and both osmotic output and urinary glucose excretion were found in diabetic rats on normal diet, but these correlations were absent in diabetic rats on synthetic diet, which showed higher urine volumes than expected from the correlations. In contrast, urine volume was significantly correlated with carbohydrate intake in diabetic rats, irrespective of the diet. Conclusions:  1) The synthetic diet dramatically increases the urine volume in STZ-DM rats irrespectively of NaCl-content. 2) Rats with STZ-DM on a normal diet show reduced water intake and urine volume in response to dietary NaCl restriction. 3) A shift to high carbohydrate diet induces polyuria in STZ-DM rats. 4) Urine volume in all STZ-DM rats only shows correlation with with dietary carbohydrate intake. 5) Glucose-driven osmotic diuresis is unlike to explain the carbohydrate-induced polyuria.

U2 - 10.1111/j.1748-1716.2011.02260.x

DO - 10.1111/j.1748-1716.2011.02260.x

M3 - Journal article

C2 - 21281457

VL - 202

SP - 47

EP - 57

JO - Acta Physiologica (Print)

JF - Acta Physiologica (Print)

SN - 1748-1708

IS - 1

ER -