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Jørgen Frøkiær

Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study

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Standard

Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study. / Thomassen, Sisse Anette; Kjærgaard, Benedict; Olsen Alstrup, Aage Kristian; Munk, Ole Lajord; Frøkiær, Jørgen; Larsson, Anders; Rasmussen, Bodil Steen.

In: Journal of Cardiothoracic and Vascular Anesthesia, Vol. 31(6), 12.2017, p. 2065-2071.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Thomassen, SA, Kjærgaard, B, Olsen Alstrup, AK, Munk, OL, Frøkiær, J, Larsson, A & Rasmussen, BS 2017, 'Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study', Journal of Cardiothoracic and Vascular Anesthesia, vol. 31(6), pp. 2065-2071. https://doi.org/10.1053/j.jvca.2017.03.027

APA

Thomassen, S. A., Kjærgaard, B., Olsen Alstrup, A. K., Munk, O. L., Frøkiær, J., Larsson, A., & Rasmussen, B. S. (2017). Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study. Journal of Cardiothoracic and Vascular Anesthesia, 31(6), 2065-2071. https://doi.org/10.1053/j.jvca.2017.03.027

CBE

Thomassen SA, Kjærgaard B, Olsen Alstrup AK, Munk OL, Frøkiær J, Larsson A, Rasmussen BS. 2017. Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study. Journal of Cardiothoracic and Vascular Anesthesia. 31(6):2065-2071. https://doi.org/10.1053/j.jvca.2017.03.027

MLA

Thomassen, Sisse Anette et al. "Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study". Journal of Cardiothoracic and Vascular Anesthesia. 2017, 31(6). 2065-2071. https://doi.org/10.1053/j.jvca.2017.03.027

Vancouver

Author

Thomassen, Sisse Anette ; Kjærgaard, Benedict ; Olsen Alstrup, Aage Kristian ; Munk, Ole Lajord ; Frøkiær, Jørgen ; Larsson, Anders ; Rasmussen, Bodil Steen. / Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study. In: Journal of Cardiothoracic and Vascular Anesthesia. 2017 ; Vol. 31(6). pp. 2065-2071.

Bibtex

@article{bb172a29d4ad422bb2f31d703ae172e2,
title = "Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study",
abstract = "OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model.DESIGN: A prospective, randomized study.SETTING: Research laboratory, single institution.PARTICIPANTS: Eight pigs (69-71 kg).INTERVENTIONS: In anesthetized pigs, normothermic CPB was established with a blood flow of 60 mL/kg/min for 1 hour. Thereafter, a low blood flow of either 47.5 or 35 mL/kg/min was applied for 1 hour followed by a blood flow of 60 mL/kg/min for an additional hour. Regional StO2 was measured continuously by placing a near-infrared spectroscopy electrode on the skin above the gracilis muscle of the noncannulated back leg. Muscle tissue perfusion was measured using positron emission tomography with (15)O-labeled water during spontaneous circulation and the different CPB blood flows. Systemic oxygen consumption was estimated by measurement of venous saturation and lactate levels.MEASUREMENTS AND MAIN RESULTS: The results showed profound systemic ischemia during low CPB blood flow. StO2 remained high until muscle tissue perfusion decreased to about 50%, after which StO2 paralleled the linear decrease in muscle tissue perfusion.CONCLUSION: In an experimental CPB animal model, StO2 was stable until muscle tissue perfusion was reduced by about 50%, and at lower blood flow levels, there was almost a linear relationship between StO2 and muscle tissue perfusion.",
keywords = "Journal Article",
author = "Thomassen, {Sisse Anette} and Benedict Kj{\ae}rgaard and {Olsen Alstrup}, {Aage Kristian} and Munk, {Ole Lajord} and J{\o}rgen Fr{\o}ki{\ae}r and Anders Larsson and Rasmussen, {Bodil Steen}",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = dec,
doi = "10.1053/j.jvca.2017.03.027",
language = "English",
volume = "31(6)",
pages = "2065--2071",
journal = "Journal of Cardiothoracic and Vascular Anesthesia",
issn = "1053-0770",
publisher = "W.B. Saunders Co.",

}

RIS

TY - JOUR

T1 - Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study

AU - Thomassen, Sisse Anette

AU - Kjærgaard, Benedict

AU - Olsen Alstrup, Aage Kristian

AU - Munk, Ole Lajord

AU - Frøkiær, Jørgen

AU - Larsson, Anders

AU - Rasmussen, Bodil Steen

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model.DESIGN: A prospective, randomized study.SETTING: Research laboratory, single institution.PARTICIPANTS: Eight pigs (69-71 kg).INTERVENTIONS: In anesthetized pigs, normothermic CPB was established with a blood flow of 60 mL/kg/min for 1 hour. Thereafter, a low blood flow of either 47.5 or 35 mL/kg/min was applied for 1 hour followed by a blood flow of 60 mL/kg/min for an additional hour. Regional StO2 was measured continuously by placing a near-infrared spectroscopy electrode on the skin above the gracilis muscle of the noncannulated back leg. Muscle tissue perfusion was measured using positron emission tomography with (15)O-labeled water during spontaneous circulation and the different CPB blood flows. Systemic oxygen consumption was estimated by measurement of venous saturation and lactate levels.MEASUREMENTS AND MAIN RESULTS: The results showed profound systemic ischemia during low CPB blood flow. StO2 remained high until muscle tissue perfusion decreased to about 50%, after which StO2 paralleled the linear decrease in muscle tissue perfusion.CONCLUSION: In an experimental CPB animal model, StO2 was stable until muscle tissue perfusion was reduced by about 50%, and at lower blood flow levels, there was almost a linear relationship between StO2 and muscle tissue perfusion.

AB - OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model.DESIGN: A prospective, randomized study.SETTING: Research laboratory, single institution.PARTICIPANTS: Eight pigs (69-71 kg).INTERVENTIONS: In anesthetized pigs, normothermic CPB was established with a blood flow of 60 mL/kg/min for 1 hour. Thereafter, a low blood flow of either 47.5 or 35 mL/kg/min was applied for 1 hour followed by a blood flow of 60 mL/kg/min for an additional hour. Regional StO2 was measured continuously by placing a near-infrared spectroscopy electrode on the skin above the gracilis muscle of the noncannulated back leg. Muscle tissue perfusion was measured using positron emission tomography with (15)O-labeled water during spontaneous circulation and the different CPB blood flows. Systemic oxygen consumption was estimated by measurement of venous saturation and lactate levels.MEASUREMENTS AND MAIN RESULTS: The results showed profound systemic ischemia during low CPB blood flow. StO2 remained high until muscle tissue perfusion decreased to about 50%, after which StO2 paralleled the linear decrease in muscle tissue perfusion.CONCLUSION: In an experimental CPB animal model, StO2 was stable until muscle tissue perfusion was reduced by about 50%, and at lower blood flow levels, there was almost a linear relationship between StO2 and muscle tissue perfusion.

KW - Journal Article

UR - https://www.ncbi.nlm.nih.gov/pubmed/28693932

U2 - 10.1053/j.jvca.2017.03.027

DO - 10.1053/j.jvca.2017.03.027

M3 - Journal article

C2 - 28693932

VL - 31(6)

SP - 2065

EP - 2071

JO - Journal of Cardiothoracic and Vascular Anesthesia

JF - Journal of Cardiothoracic and Vascular Anesthesia

SN - 1053-0770

ER -