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Jørgen Frøkiær

Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction

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Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction. / Schelde, Astrid Blicher; Schmidt, Morten; Madsen, Morten; Nielsen, Søren Steen; Frøkiær, Jørgen; Christiansen, Christian Fynbo.

In: Clinical epidemiology, Vol. 11, 2019, p. 901-910.

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@article{3eba29bcd0aa4b5e956a21341928045c,
title = "Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction",
abstract = "Background: Comorbidity is common among patients with myocardial infarction (MI). We examined whether comorbidity level modified the single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)-based prediction of 5-year risk of MI and all-cause death in patients with MI.Methods: This cohort study included patients with prior MI having a SPECT MPI at Aarhus University Hospital, Denmark, 1999-2011. Using nationwide registries, we obtained information on comorbidity levels (low, moderate, and severe) and outcomes. We computed risk and hazard ratios (HRs) with 95% confidence intervals (CIs) for MI and all-cause death, comparing normal (no defects) versus abnormal scan (reversible and/or fixed defects) using Cox regression adjusting for sex, age, and comorbidity level.Results: We identified 1,192 patients with MI before SPECT MPI. The 5-year risk for patients with normal versus abnormal scans were 11.7% versus 18.3% for MI, and 8.0% versus 13.2% for all-cause death, respectively. The overall 5-year adjusted HR (aHR) of MI was 1.56 (95% CI: 1.09-2.21), 1.33 (95% CI: 0.82-2.15) with low comorbidity, 1.39 (95% CI: 0.68-2.83) with moderate comorbidity, and 2.53 (95% CI: 1.14-5.62) with severe comorbidity. Similarly, the 5-year aHR for all-cause death was 1.39 (95% CI: 0.90-2.14) overall; 2.33 (95% CI: 0.79-6.84) with low comorbidity, 2.05 (95% CI: 0.69-6.06) with moderate comorbidity, and 1.07 (95% CI: 0.64-1.80) with severe comorbidity.Conclusion: We conclude that comorbidity level may modify the 5-year risk prediction associated with an abnormal SPECT MPI scan in patients with previous MI.",
author = "Schelde, {Astrid Blicher} and Morten Schmidt and Morten Madsen and Nielsen, {S{\o}ren Steen} and J{\o}rgen Fr{\o}ki{\ae}r and Christiansen, {Christian Fynbo}",
note = "{\textcopyright} 2019 Schelde et al.",
year = "2019",
doi = "10.2147/CLEP.S211555",
language = "English",
volume = "11",
pages = "901--910",
journal = "Clinical Epidemiology",
issn = "1179-1349",
publisher = "Dove Medical Press Ltd.(Dovepress)",

}

RIS

TY - JOUR

T1 - Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction

AU - Schelde, Astrid Blicher

AU - Schmidt, Morten

AU - Madsen, Morten

AU - Nielsen, Søren Steen

AU - Frøkiær, Jørgen

AU - Christiansen, Christian Fynbo

N1 - © 2019 Schelde et al.

PY - 2019

Y1 - 2019

N2 - Background: Comorbidity is common among patients with myocardial infarction (MI). We examined whether comorbidity level modified the single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)-based prediction of 5-year risk of MI and all-cause death in patients with MI.Methods: This cohort study included patients with prior MI having a SPECT MPI at Aarhus University Hospital, Denmark, 1999-2011. Using nationwide registries, we obtained information on comorbidity levels (low, moderate, and severe) and outcomes. We computed risk and hazard ratios (HRs) with 95% confidence intervals (CIs) for MI and all-cause death, comparing normal (no defects) versus abnormal scan (reversible and/or fixed defects) using Cox regression adjusting for sex, age, and comorbidity level.Results: We identified 1,192 patients with MI before SPECT MPI. The 5-year risk for patients with normal versus abnormal scans were 11.7% versus 18.3% for MI, and 8.0% versus 13.2% for all-cause death, respectively. The overall 5-year adjusted HR (aHR) of MI was 1.56 (95% CI: 1.09-2.21), 1.33 (95% CI: 0.82-2.15) with low comorbidity, 1.39 (95% CI: 0.68-2.83) with moderate comorbidity, and 2.53 (95% CI: 1.14-5.62) with severe comorbidity. Similarly, the 5-year aHR for all-cause death was 1.39 (95% CI: 0.90-2.14) overall; 2.33 (95% CI: 0.79-6.84) with low comorbidity, 2.05 (95% CI: 0.69-6.06) with moderate comorbidity, and 1.07 (95% CI: 0.64-1.80) with severe comorbidity.Conclusion: We conclude that comorbidity level may modify the 5-year risk prediction associated with an abnormal SPECT MPI scan in patients with previous MI.

AB - Background: Comorbidity is common among patients with myocardial infarction (MI). We examined whether comorbidity level modified the single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)-based prediction of 5-year risk of MI and all-cause death in patients with MI.Methods: This cohort study included patients with prior MI having a SPECT MPI at Aarhus University Hospital, Denmark, 1999-2011. Using nationwide registries, we obtained information on comorbidity levels (low, moderate, and severe) and outcomes. We computed risk and hazard ratios (HRs) with 95% confidence intervals (CIs) for MI and all-cause death, comparing normal (no defects) versus abnormal scan (reversible and/or fixed defects) using Cox regression adjusting for sex, age, and comorbidity level.Results: We identified 1,192 patients with MI before SPECT MPI. The 5-year risk for patients with normal versus abnormal scans were 11.7% versus 18.3% for MI, and 8.0% versus 13.2% for all-cause death, respectively. The overall 5-year adjusted HR (aHR) of MI was 1.56 (95% CI: 1.09-2.21), 1.33 (95% CI: 0.82-2.15) with low comorbidity, 1.39 (95% CI: 0.68-2.83) with moderate comorbidity, and 2.53 (95% CI: 1.14-5.62) with severe comorbidity. Similarly, the 5-year aHR for all-cause death was 1.39 (95% CI: 0.90-2.14) overall; 2.33 (95% CI: 0.79-6.84) with low comorbidity, 2.05 (95% CI: 0.69-6.06) with moderate comorbidity, and 1.07 (95% CI: 0.64-1.80) with severe comorbidity.Conclusion: We conclude that comorbidity level may modify the 5-year risk prediction associated with an abnormal SPECT MPI scan in patients with previous MI.

U2 - 10.2147/CLEP.S211555

DO - 10.2147/CLEP.S211555

M3 - Journal article

C2 - 31576177

VL - 11

SP - 901

EP - 910

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -