Jørgen Frøkiær

Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men. / Skov, Jeppe; Dejgaard, Anders; Frøkiær, Jørgen et al.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 4, 05.03.2013, p. E664-71.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Skov, J, Dejgaard, A, Frøkiær, J, Holst, JJ, Jonassen, T, Rittig, S & Christiansen, JS 2013, 'Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 4, pp. E664-71. https://doi.org/10.1210/jc.2012-3855

APA

Skov, J., Dejgaard, A., Frøkiær, J., Holst, J. J., Jonassen, T., Rittig, S., & Christiansen, J. S. (2013). Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men. Journal of Clinical Endocrinology and Metabolism, 98(4), E664-71. https://doi.org/10.1210/jc.2012-3855

CBE

Skov J, Dejgaard A, Frøkiær J, Holst JJ, Jonassen T, Rittig S, Christiansen JS. 2013. Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men. Journal of Clinical Endocrinology and Metabolism. 98(4):E664-71. https://doi.org/10.1210/jc.2012-3855

MLA

Vancouver

Skov J, Dejgaard A, Frøkiær J, Holst JJ, Jonassen T, Rittig S et al. Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men. Journal of Clinical Endocrinology and Metabolism. 2013 Mar 5;98(4):E664-71. https://doi.org/10.1210/jc.2012-3855

Author

Skov, Jeppe ; Dejgaard, Anders ; Frøkiær, Jørgen et al. / Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 4. pp. E664-71.

Bibtex

@article{0e4b9d21b08b4ea2863264ae41984dcb,
title = "Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men",
abstract = "Introduction:Glucagon-like peptide-1 (GLP-1) is an incretin hormone with multiple actions in addition to control of glucose homeostasis. GLP-1 is known to cause natriuresis in humans, but the effects on basic renal physiology are still partly unknown.Subjects and Methods:Twelve healthy young males were examined in a randomized, controlled, double-blinded, single-day, crossover trial to evaluate the effects of 2 hours GLP-1 infusion on kidney functions. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed with (51)Cr-EDTA and (123)I-hippuran, respectively, using a constant infusion renal clearance technique based on timed urine sampling.Results:GLP-1 had no significant effect on either GFR [+1.9%, 95% confidence interval (-0.8; 4.6%)] or RPF [+2.4%, 95% confidence interval (-3.6; 8.8%)]. Fractional urine excretion of lithium increased 9% (P = .013) and renal sodium clearance increased 40% (P = .007). Angiotensin II decreased 19% (P = .003), whereas renin, aldosterone, and the urinary excretion of angiotensinogen showed no significant changes. GLP-1 did not affect blood pressure but induced a small transient increase in heart rate.Conclusion:The results indicate that although GLP-1 markedly reduces proximal tubule sodium reabsorption, the acute effects on GFR and RPF are very limited in healthy humans. The finding of GLP-1's ability to reduce angiotensin II concentration is novel and should be further elucidated.",
author = "Jeppe Skov and Anders Dejgaard and J{\o}rgen Fr{\o}ki{\ae}r and Holst, {Jens Juul} and Thomas Jonassen and S{\o}ren Rittig and Christiansen, {Jens Sandahl}",
year = "2013",
month = mar,
day = "5",
doi = "10.1210/jc.2012-3855",
language = "English",
volume = "98",
pages = "E664--71",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Glucagon-Like Peptide-1: Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men

AU - Skov, Jeppe

AU - Dejgaard, Anders

AU - Frøkiær, Jørgen

AU - Holst, Jens Juul

AU - Jonassen, Thomas

AU - Rittig, Søren

AU - Christiansen, Jens Sandahl

PY - 2013/3/5

Y1 - 2013/3/5

N2 - Introduction:Glucagon-like peptide-1 (GLP-1) is an incretin hormone with multiple actions in addition to control of glucose homeostasis. GLP-1 is known to cause natriuresis in humans, but the effects on basic renal physiology are still partly unknown.Subjects and Methods:Twelve healthy young males were examined in a randomized, controlled, double-blinded, single-day, crossover trial to evaluate the effects of 2 hours GLP-1 infusion on kidney functions. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed with (51)Cr-EDTA and (123)I-hippuran, respectively, using a constant infusion renal clearance technique based on timed urine sampling.Results:GLP-1 had no significant effect on either GFR [+1.9%, 95% confidence interval (-0.8; 4.6%)] or RPF [+2.4%, 95% confidence interval (-3.6; 8.8%)]. Fractional urine excretion of lithium increased 9% (P = .013) and renal sodium clearance increased 40% (P = .007). Angiotensin II decreased 19% (P = .003), whereas renin, aldosterone, and the urinary excretion of angiotensinogen showed no significant changes. GLP-1 did not affect blood pressure but induced a small transient increase in heart rate.Conclusion:The results indicate that although GLP-1 markedly reduces proximal tubule sodium reabsorption, the acute effects on GFR and RPF are very limited in healthy humans. The finding of GLP-1's ability to reduce angiotensin II concentration is novel and should be further elucidated.

AB - Introduction:Glucagon-like peptide-1 (GLP-1) is an incretin hormone with multiple actions in addition to control of glucose homeostasis. GLP-1 is known to cause natriuresis in humans, but the effects on basic renal physiology are still partly unknown.Subjects and Methods:Twelve healthy young males were examined in a randomized, controlled, double-blinded, single-day, crossover trial to evaluate the effects of 2 hours GLP-1 infusion on kidney functions. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed with (51)Cr-EDTA and (123)I-hippuran, respectively, using a constant infusion renal clearance technique based on timed urine sampling.Results:GLP-1 had no significant effect on either GFR [+1.9%, 95% confidence interval (-0.8; 4.6%)] or RPF [+2.4%, 95% confidence interval (-3.6; 8.8%)]. Fractional urine excretion of lithium increased 9% (P = .013) and renal sodium clearance increased 40% (P = .007). Angiotensin II decreased 19% (P = .003), whereas renin, aldosterone, and the urinary excretion of angiotensinogen showed no significant changes. GLP-1 did not affect blood pressure but induced a small transient increase in heart rate.Conclusion:The results indicate that although GLP-1 markedly reduces proximal tubule sodium reabsorption, the acute effects on GFR and RPF are very limited in healthy humans. The finding of GLP-1's ability to reduce angiotensin II concentration is novel and should be further elucidated.

U2 - 10.1210/jc.2012-3855

DO - 10.1210/jc.2012-3855

M3 - Journal article

C2 - 23463656

VL - 98

SP - E664-71

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -