Jørgen Frøkiær

Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET

Research output: Contribution to conferencePosterResearchpeer-review

Standard

Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET. / Harms, Hans; Tolbod, Lars Poulsen; Hansson, Nils Henrik; Kero, Tanja; Orndahl, LH; Kim, Won Yong; Bouchelouche, Kirsten; Wiggers, Henrik; Frøkiær, Jørgen; Sørensen, Jens.

2015. Poster session presented at International Conference of Nuclear Cardiology and Cardiac CT, Madrid, Spain.

Research output: Contribution to conferencePosterResearchpeer-review

Harvard

Harms, H, Tolbod, LP, Hansson, NH, Kero, T, Orndahl, LH, Kim, WY, Bouchelouche, K, Wiggers, H, Frøkiær, J & Sørensen, J 2015, 'Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET', International Conference of Nuclear Cardiology and Cardiac CT, Madrid, Spain, 03/05/2015 - 05/05/2015. https://doi.org/10.1093/ehjci/jev054

APA

Harms, H., Tolbod, L. P., Hansson, N. H., Kero, T., Orndahl, LH., Kim, W. Y., Bouchelouche, K., Wiggers, H., Frøkiær, J., & Sørensen, J. (2015). Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET. Poster session presented at International Conference of Nuclear Cardiology and Cardiac CT, Madrid, Spain. https://doi.org/10.1093/ehjci/jev054

CBE

Harms H, Tolbod LP, Hansson NH, Kero T, Orndahl LH, Kim WY, Bouchelouche K, Wiggers H, Frøkiær J, Sørensen J. 2015. Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET. Poster session presented at International Conference of Nuclear Cardiology and Cardiac CT, Madrid, Spain. https://doi.org/10.1093/ehjci/jev054

MLA

Harms, Hans et al. Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET. International Conference of Nuclear Cardiology and Cardiac CT, 03 May 2015, Madrid, Spain, Poster, 2015. https://doi.org/10.1093/ehjci/jev054

Vancouver

Harms H, Tolbod LP, Hansson NH, Kero T, Orndahl LH, Kim WY et al. Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET. 2015. Poster session presented at International Conference of Nuclear Cardiology and Cardiac CT, Madrid, Spain. https://doi.org/10.1093/ehjci/jev054

Author

Harms, Hans ; Tolbod, Lars Poulsen ; Hansson, Nils Henrik ; Kero, Tanja ; Orndahl, LH ; Kim, Won Yong ; Bouchelouche, Kirsten ; Wiggers, Henrik ; Frøkiær, Jørgen ; Sørensen, Jens. / Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET. Poster session presented at International Conference of Nuclear Cardiology and Cardiac CT, Madrid, Spain.

Bibtex

@conference{7b5448a881214b29b6cfd191ad950263,
title = "Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET",
abstract = "Background: Dynamic 11C-acetate PET is used to quantify oxygen metabolism, which is used to calculate left ventricular (LV) myocardial efficiency, an early marker of heart failure. This requires estimation of LV myocardial mass and is typically derived from a separate cardiovascular magnetic resonance (CMR) scan. The aim of this study was to explore the feasibility of estimating myocardial mass directly from a dynamic 11C-acetate PET scan.Methods: 21 subjects underwent a 27-min 11C-acetate PET scan on a Siemens Biograph TruePoint 64 PET/CT scanner. In addition, 10 subjects underwent a dynamic 11C-acetate 27-min PET scan on a GE Discovery ST PET/CT scanner. Parametric images of uptake rate K1 and both arterial (VA) and venous (VV) spillover fractions were generated using a basis function implementation of the standard single tissue compartment model using non-gated dynamic data. The LV wall was defined automatically using obtained parametric images and myocardial mass was derived from the volumes of the obtained myocardial segments. LV myocardial mass derived from CMR was used as gold standard reference.Results: A good agreement between LV mass derived using PET and CMR was found for both groups (Intraclass correlation coefficient [ICC]=0.95 and ICC=0.89, respectively). No significant differences were found between LV mass based on PET and CMR for both groups (p=0.69 and p=0.53, respectively).Conclusion: LV myocardial mass can be obtained automatically from a single non-gated dynamic 11C-acetate scan. This greatly simplifies both the scanning protocol and data analysis required for calculation of LV myocardial external efficiency.",
author = "Hans Harms and Tolbod, {Lars Poulsen} and Hansson, {Nils Henrik} and Tanja Kero and LH Orndahl and Kim, {Won Yong} and Kirsten Bouchelouche and Henrik Wiggers and J{\o}rgen Fr{\o}ki{\ae}r and Jens S{\o}rensen",
year = "2015",
month = may,
day = "1",
doi = "10.1093/ehjci/jev054",
language = "English",
note = "null ; Conference date: 03-05-2015 Through 05-05-2015",

}

RIS

TY - CONF

T1 - Extraction of left ventricular myocardial mass from dynamic 11C-acetate PET

AU - Harms, Hans

AU - Tolbod, Lars Poulsen

AU - Hansson, Nils Henrik

AU - Kero, Tanja

AU - Orndahl, LH

AU - Kim, Won Yong

AU - Bouchelouche, Kirsten

AU - Wiggers, Henrik

AU - Frøkiær, Jørgen

AU - Sørensen, Jens

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Dynamic 11C-acetate PET is used to quantify oxygen metabolism, which is used to calculate left ventricular (LV) myocardial efficiency, an early marker of heart failure. This requires estimation of LV myocardial mass and is typically derived from a separate cardiovascular magnetic resonance (CMR) scan. The aim of this study was to explore the feasibility of estimating myocardial mass directly from a dynamic 11C-acetate PET scan.Methods: 21 subjects underwent a 27-min 11C-acetate PET scan on a Siemens Biograph TruePoint 64 PET/CT scanner. In addition, 10 subjects underwent a dynamic 11C-acetate 27-min PET scan on a GE Discovery ST PET/CT scanner. Parametric images of uptake rate K1 and both arterial (VA) and venous (VV) spillover fractions were generated using a basis function implementation of the standard single tissue compartment model using non-gated dynamic data. The LV wall was defined automatically using obtained parametric images and myocardial mass was derived from the volumes of the obtained myocardial segments. LV myocardial mass derived from CMR was used as gold standard reference.Results: A good agreement between LV mass derived using PET and CMR was found for both groups (Intraclass correlation coefficient [ICC]=0.95 and ICC=0.89, respectively). No significant differences were found between LV mass based on PET and CMR for both groups (p=0.69 and p=0.53, respectively).Conclusion: LV myocardial mass can be obtained automatically from a single non-gated dynamic 11C-acetate scan. This greatly simplifies both the scanning protocol and data analysis required for calculation of LV myocardial external efficiency.

AB - Background: Dynamic 11C-acetate PET is used to quantify oxygen metabolism, which is used to calculate left ventricular (LV) myocardial efficiency, an early marker of heart failure. This requires estimation of LV myocardial mass and is typically derived from a separate cardiovascular magnetic resonance (CMR) scan. The aim of this study was to explore the feasibility of estimating myocardial mass directly from a dynamic 11C-acetate PET scan.Methods: 21 subjects underwent a 27-min 11C-acetate PET scan on a Siemens Biograph TruePoint 64 PET/CT scanner. In addition, 10 subjects underwent a dynamic 11C-acetate 27-min PET scan on a GE Discovery ST PET/CT scanner. Parametric images of uptake rate K1 and both arterial (VA) and venous (VV) spillover fractions were generated using a basis function implementation of the standard single tissue compartment model using non-gated dynamic data. The LV wall was defined automatically using obtained parametric images and myocardial mass was derived from the volumes of the obtained myocardial segments. LV myocardial mass derived from CMR was used as gold standard reference.Results: A good agreement between LV mass derived using PET and CMR was found for both groups (Intraclass correlation coefficient [ICC]=0.95 and ICC=0.89, respectively). No significant differences were found between LV mass based on PET and CMR for both groups (p=0.69 and p=0.53, respectively).Conclusion: LV myocardial mass can be obtained automatically from a single non-gated dynamic 11C-acetate scan. This greatly simplifies both the scanning protocol and data analysis required for calculation of LV myocardial external efficiency.

U2 - 10.1093/ehjci/jev054

DO - 10.1093/ehjci/jev054

M3 - Poster

C2 - 25939931

Y2 - 3 May 2015 through 5 May 2015

ER -