Jørgen Frøkiær

Compromised cardiac function in exercising teenagers with pectus excavatum

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Compromised cardiac function in exercising teenagers with pectus excavatum. / Lesbo, Maj; Tang, Mariann; Nielsen, Hans Henrik; Frøkiær, Jørgen; Lundorf, Erik; Pilegaard, Hans K; Hjortdal, Vibeke E.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 13, No. 4, 01.10.2011, p. 377-80.

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@article{96a96ac11222475d8f3ebc89b848a335,
title = "Compromised cardiac function in exercising teenagers with pectus excavatum",
abstract = "Patients with pectus excavatum complain about fatigue, tachypnea, discomfort and dyspnea, but the existence of an equivalent underlying pathophysiology has been questioned. We investigated 75 teenagers (49 pectus excavatum patients and 26 age matched controls) at rest and during bicycle exercise at submaximal exercise levels. At rest cardiac function was determined using echocardiography. During rest and exercise, cardiac output, heart rate and aerobic exercise capacity were measured using photo-acoustic gas-rebreathing technique for non-invasive determination of the cardiopulmonary function. At rest, no cardiac differences were found between control subjects and patients with pectus excavatum. During submaximal exercise, cardiac index was lower 6.6(6.3-7.0) l/min/m(2) among the pectus patients as compared to the control subjects 8.0(7.3-8.8) l/min/m(2), P=0.0001. The lower cardiac output among the pectus patients was due to a lower stroke index 42(39-45) ml/beat/m(2) as compared to controls 54(44-64) ml/beat/m(2), P=0.0022, whereas heart rate was unchanged. Cardiac function is significantly impaired at submaximal exercise level compared to healthy age matched controls.",
author = "Maj Lesbo and Mariann Tang and Nielsen, {Hans Henrik} and J{\o}rgen Fr{\o}ki{\ae}r and Erik Lundorf and Pilegaard, {Hans K} and Hjortdal, {Vibeke E}",
year = "2011",
month = oct,
day = "1",
doi = "10.1510/icvts.2011.267054",
language = "English",
volume = "13",
pages = "377--80",
journal = "Interactive Cardiovascular and Thoracic Surgery",
issn = "1569-9293",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Compromised cardiac function in exercising teenagers with pectus excavatum

AU - Lesbo, Maj

AU - Tang, Mariann

AU - Nielsen, Hans Henrik

AU - Frøkiær, Jørgen

AU - Lundorf, Erik

AU - Pilegaard, Hans K

AU - Hjortdal, Vibeke E

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Patients with pectus excavatum complain about fatigue, tachypnea, discomfort and dyspnea, but the existence of an equivalent underlying pathophysiology has been questioned. We investigated 75 teenagers (49 pectus excavatum patients and 26 age matched controls) at rest and during bicycle exercise at submaximal exercise levels. At rest cardiac function was determined using echocardiography. During rest and exercise, cardiac output, heart rate and aerobic exercise capacity were measured using photo-acoustic gas-rebreathing technique for non-invasive determination of the cardiopulmonary function. At rest, no cardiac differences were found between control subjects and patients with pectus excavatum. During submaximal exercise, cardiac index was lower 6.6(6.3-7.0) l/min/m(2) among the pectus patients as compared to the control subjects 8.0(7.3-8.8) l/min/m(2), P=0.0001. The lower cardiac output among the pectus patients was due to a lower stroke index 42(39-45) ml/beat/m(2) as compared to controls 54(44-64) ml/beat/m(2), P=0.0022, whereas heart rate was unchanged. Cardiac function is significantly impaired at submaximal exercise level compared to healthy age matched controls.

AB - Patients with pectus excavatum complain about fatigue, tachypnea, discomfort and dyspnea, but the existence of an equivalent underlying pathophysiology has been questioned. We investigated 75 teenagers (49 pectus excavatum patients and 26 age matched controls) at rest and during bicycle exercise at submaximal exercise levels. At rest cardiac function was determined using echocardiography. During rest and exercise, cardiac output, heart rate and aerobic exercise capacity were measured using photo-acoustic gas-rebreathing technique for non-invasive determination of the cardiopulmonary function. At rest, no cardiac differences were found between control subjects and patients with pectus excavatum. During submaximal exercise, cardiac index was lower 6.6(6.3-7.0) l/min/m(2) among the pectus patients as compared to the control subjects 8.0(7.3-8.8) l/min/m(2), P=0.0001. The lower cardiac output among the pectus patients was due to a lower stroke index 42(39-45) ml/beat/m(2) as compared to controls 54(44-64) ml/beat/m(2), P=0.0022, whereas heart rate was unchanged. Cardiac function is significantly impaired at submaximal exercise level compared to healthy age matched controls.

U2 - 10.1510/icvts.2011.267054

DO - 10.1510/icvts.2011.267054

M3 - Journal article

C2 - 21788301

VL - 13

SP - 377

EP - 380

JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

SN - 1569-9293

IS - 4

ER -