Jørgen Frøkiær

Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: An experimental porcine study

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Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: An experimental porcine study. / Thomassen, Sisse Anette; Kjaergaard, Benedict; Alstrup, Aage Kristian Olsen; Munk, Ole Lajord; Frøkiær, Jørgen; Larsson, Anders; Rasmussen, Bodil Steen.

In: Perfusion, Vol. 33, No. 5, 30.01.2018, p. 346-353.

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Thomassen, Sisse Anette ; Kjaergaard, Benedict ; Alstrup, Aage Kristian Olsen ; Munk, Ole Lajord ; Frøkiær, Jørgen ; Larsson, Anders ; Rasmussen, Bodil Steen. / Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: An experimental porcine study. In: Perfusion. 2018 ; Vol. 33, No. 5. pp. 346-353.

Bibtex

@article{01957053353f4cea837d4a974f5b4cc1,
title = "Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: An experimental porcine study",
abstract = "Background: Mean arterial blood pressure (MAP) and/or pump flow during normothermic cardiopulmonary bypass (CPB) are the most important factors of cerebral perfusion. The aim of this study was to explore the influence of CPB blood flow on cerebral blood flow (CBF) measured by dynamic positron emission tomography (PET) using 15O-labelled water with no pharmacological interventions to maintain the MAP. Methods: Eight pigs (69-71 kg) were connected to normothermic CPB. After 60 minutes (min) with a CPB pump flow of 60 mL/kg/min, the pigs were changed to either 35 mL/kg/min or 47.5 mL/kg/min for 60 min and, thereafter, all the pigs returned to 60 mL/kg/min for another 60 min. The MAP was measured continuously and the CBF was measured by positron emission tomography (PET) during spontaneous circulation and at each CPB pump flow after 30 min of steady state. Results: Two pigs were excluded due to complications. CBF increased from spontaneous circulation to a CPB pump flow of 60 mL/kg/min. A reduction in CPB pump flow to 47.5 mL/kg/min (n=3) resulted in only minor changes in CBF while areduction to 35 mL/kg/min (n=3) caused a pronounced change (correlation coefficient (R2) 0.56). A return of CPB pump flow to 60 mL/kg/min was followed by an increase in CBF, except in the one pig with the lowest CBF during low flow(R2=0.44). CBF and MAP were not correlated (R2=0.20). Conclusion: In this experimental porcine study, a relationship was observed between pump flow and CBF under normothermic low-flow CPB. The effect of low pump flow on MAP showed substantial variations, with no correlation between CBF and MAP.",
keywords = "animal study, cardiopulmonary bypass, cerebral blood flow, mean arterial blood pressure, positron emission tomography, pump flow",
author = "Thomassen, {Sisse Anette} and Benedict Kjaergaard and Alstrup, {Aage Kristian Olsen} and Munk, {Ole Lajord} and J{\o}rgen Fr{\o}ki{\ae}r and Anders Larsson and Rasmussen, {Bodil Steen}",
year = "2018",
month = jan,
day = "30",
doi = "10.1177/0267659118755271",
language = "English",
volume = "33",
pages = "346--353",
journal = "Perfusion",
issn = "0267-6591",
publisher = "SAGE Publications Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: An experimental porcine study

AU - Thomassen, Sisse Anette

AU - Kjaergaard, Benedict

AU - Alstrup, Aage Kristian Olsen

AU - Munk, Ole Lajord

AU - Frøkiær, Jørgen

AU - Larsson, Anders

AU - Rasmussen, Bodil Steen

PY - 2018/1/30

Y1 - 2018/1/30

N2 - Background: Mean arterial blood pressure (MAP) and/or pump flow during normothermic cardiopulmonary bypass (CPB) are the most important factors of cerebral perfusion. The aim of this study was to explore the influence of CPB blood flow on cerebral blood flow (CBF) measured by dynamic positron emission tomography (PET) using 15O-labelled water with no pharmacological interventions to maintain the MAP. Methods: Eight pigs (69-71 kg) were connected to normothermic CPB. After 60 minutes (min) with a CPB pump flow of 60 mL/kg/min, the pigs were changed to either 35 mL/kg/min or 47.5 mL/kg/min for 60 min and, thereafter, all the pigs returned to 60 mL/kg/min for another 60 min. The MAP was measured continuously and the CBF was measured by positron emission tomography (PET) during spontaneous circulation and at each CPB pump flow after 30 min of steady state. Results: Two pigs were excluded due to complications. CBF increased from spontaneous circulation to a CPB pump flow of 60 mL/kg/min. A reduction in CPB pump flow to 47.5 mL/kg/min (n=3) resulted in only minor changes in CBF while areduction to 35 mL/kg/min (n=3) caused a pronounced change (correlation coefficient (R2) 0.56). A return of CPB pump flow to 60 mL/kg/min was followed by an increase in CBF, except in the one pig with the lowest CBF during low flow(R2=0.44). CBF and MAP were not correlated (R2=0.20). Conclusion: In this experimental porcine study, a relationship was observed between pump flow and CBF under normothermic low-flow CPB. The effect of low pump flow on MAP showed substantial variations, with no correlation between CBF and MAP.

AB - Background: Mean arterial blood pressure (MAP) and/or pump flow during normothermic cardiopulmonary bypass (CPB) are the most important factors of cerebral perfusion. The aim of this study was to explore the influence of CPB blood flow on cerebral blood flow (CBF) measured by dynamic positron emission tomography (PET) using 15O-labelled water with no pharmacological interventions to maintain the MAP. Methods: Eight pigs (69-71 kg) were connected to normothermic CPB. After 60 minutes (min) with a CPB pump flow of 60 mL/kg/min, the pigs were changed to either 35 mL/kg/min or 47.5 mL/kg/min for 60 min and, thereafter, all the pigs returned to 60 mL/kg/min for another 60 min. The MAP was measured continuously and the CBF was measured by positron emission tomography (PET) during spontaneous circulation and at each CPB pump flow after 30 min of steady state. Results: Two pigs were excluded due to complications. CBF increased from spontaneous circulation to a CPB pump flow of 60 mL/kg/min. A reduction in CPB pump flow to 47.5 mL/kg/min (n=3) resulted in only minor changes in CBF while areduction to 35 mL/kg/min (n=3) caused a pronounced change (correlation coefficient (R2) 0.56). A return of CPB pump flow to 60 mL/kg/min was followed by an increase in CBF, except in the one pig with the lowest CBF during low flow(R2=0.44). CBF and MAP were not correlated (R2=0.20). Conclusion: In this experimental porcine study, a relationship was observed between pump flow and CBF under normothermic low-flow CPB. The effect of low pump flow on MAP showed substantial variations, with no correlation between CBF and MAP.

KW - animal study

KW - cardiopulmonary bypass

KW - cerebral blood flow

KW - mean arterial blood pressure

KW - positron emission tomography

KW - pump flow

UR - http://www.scopus.com/inward/record.url?scp=85041922035&partnerID=8YFLogxK

U2 - 10.1177/0267659118755271

DO - 10.1177/0267659118755271

M3 - Journal article

C2 - 29380669

VL - 33

SP - 346

EP - 353

JO - Perfusion

JF - Perfusion

SN - 0267-6591

IS - 5

ER -