Joel Fredrik Astrup Aanerud

Sex differences of human cortical blood flow and energy metabolism: 2440

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Sex differences of human cortical blood flow and energy metabolism : 2440. / Aanerud, Joel; Borghammer, Per; Rodell, Anders; Jónsdottir, Kristjana Y; Gjedde, Albert.

In: Journal of Cerebral Blood Flow and Metabolism, No. 37(7), 01.07.2017, p. 2333-2440.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Aanerud, J, Borghammer, P, Rodell, A, Jónsdottir, KY & Gjedde, A 2017, 'Sex differences of human cortical blood flow and energy metabolism: 2440', Journal of Cerebral Blood Flow and Metabolism, no. 37(7), pp. 2333-2440. https://doi.org/10.1177/0271678X16668536

APA

Aanerud, J., Borghammer, P., Rodell, A., Jónsdottir, K. Y., & Gjedde, A. (2017). Sex differences of human cortical blood flow and energy metabolism: 2440. Journal of Cerebral Blood Flow and Metabolism, (37(7)), 2333-2440. https://doi.org/10.1177/0271678X16668536

CBE

Aanerud J, Borghammer P, Rodell A, Jónsdottir KY, Gjedde A. 2017. Sex differences of human cortical blood flow and energy metabolism: 2440. Journal of Cerebral Blood Flow and Metabolism. (37(7)):2333-2440. https://doi.org/10.1177/0271678X16668536

MLA

Vancouver

Aanerud J, Borghammer P, Rodell A, Jónsdottir KY, Gjedde A. Sex differences of human cortical blood flow and energy metabolism: 2440. Journal of Cerebral Blood Flow and Metabolism. 2017 Jul 1;(37(7)):2333-2440. https://doi.org/10.1177/0271678X16668536

Author

Aanerud, Joel ; Borghammer, Per ; Rodell, Anders ; Jónsdottir, Kristjana Y ; Gjedde, Albert. / Sex differences of human cortical blood flow and energy metabolism : 2440. In: Journal of Cerebral Blood Flow and Metabolism. 2017 ; No. 37(7). pp. 2333-2440.

Bibtex

@article{565a736995de4ab6908d8dad2074af5e,
title = "Sex differences of human cortical blood flow and energy metabolism: 2440",
abstract = "Brain energy metabolism is held to reflect energy demanding processes in neuropil related to the density and activity of synapses. There is recent evidence that men have higher density of synapses in temporal cortex than women. One consequence of these differences would be different rates of cortical energy turnover and blood flow in men and women. To test the hypotheses that rates of oxygen consumption (CMRO2) and cerebral blood flow are higher in men than in women in regions of cerebral cortex, and that the differences persist with aging, we used positron emission tomography to determine cerebral blood flow and cerebral metabolic rate of oxygen as functions of age in healthy volunteers of both sexes. Cerebral metabolic rate of oxygen did not change with age for either sex and there were no differences of mean values of cerebral metabolic rate of oxygen between men and women in cerebral cortex. Women had significant decreases of cerebral blood flow as function of age in frontal and parietal lobes. Young women had significantly higher cerebral blood flow than men in frontal and temporal lobes, but these differences had disappeared at age 65. The absent sex difference of cerebral energy turnover suggests that the known differences of synaptic density between the sexes are counteracted by opposite differences of individual synaptic activity.",
author = "Joel Aanerud and Per Borghammer and Anders Rodell and J{\'o}nsdottir, {Kristjana Y} and Albert Gjedde",
note = "{\textcopyright} The Author(s) 2016.",
year = "2017",
month = jul,
day = "1",
doi = "10.1177/0271678X16668536",
language = "English",
pages = "2333--2440",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications Ltd",
number = "37(7)",

}

RIS

TY - JOUR

T1 - Sex differences of human cortical blood flow and energy metabolism

T2 - 2440

AU - Aanerud, Joel

AU - Borghammer, Per

AU - Rodell, Anders

AU - Jónsdottir, Kristjana Y

AU - Gjedde, Albert

N1 - © The Author(s) 2016.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Brain energy metabolism is held to reflect energy demanding processes in neuropil related to the density and activity of synapses. There is recent evidence that men have higher density of synapses in temporal cortex than women. One consequence of these differences would be different rates of cortical energy turnover and blood flow in men and women. To test the hypotheses that rates of oxygen consumption (CMRO2) and cerebral blood flow are higher in men than in women in regions of cerebral cortex, and that the differences persist with aging, we used positron emission tomography to determine cerebral blood flow and cerebral metabolic rate of oxygen as functions of age in healthy volunteers of both sexes. Cerebral metabolic rate of oxygen did not change with age for either sex and there were no differences of mean values of cerebral metabolic rate of oxygen between men and women in cerebral cortex. Women had significant decreases of cerebral blood flow as function of age in frontal and parietal lobes. Young women had significantly higher cerebral blood flow than men in frontal and temporal lobes, but these differences had disappeared at age 65. The absent sex difference of cerebral energy turnover suggests that the known differences of synaptic density between the sexes are counteracted by opposite differences of individual synaptic activity.

AB - Brain energy metabolism is held to reflect energy demanding processes in neuropil related to the density and activity of synapses. There is recent evidence that men have higher density of synapses in temporal cortex than women. One consequence of these differences would be different rates of cortical energy turnover and blood flow in men and women. To test the hypotheses that rates of oxygen consumption (CMRO2) and cerebral blood flow are higher in men than in women in regions of cerebral cortex, and that the differences persist with aging, we used positron emission tomography to determine cerebral blood flow and cerebral metabolic rate of oxygen as functions of age in healthy volunteers of both sexes. Cerebral metabolic rate of oxygen did not change with age for either sex and there were no differences of mean values of cerebral metabolic rate of oxygen between men and women in cerebral cortex. Women had significant decreases of cerebral blood flow as function of age in frontal and parietal lobes. Young women had significantly higher cerebral blood flow than men in frontal and temporal lobes, but these differences had disappeared at age 65. The absent sex difference of cerebral energy turnover suggests that the known differences of synaptic density between the sexes are counteracted by opposite differences of individual synaptic activity.

U2 - 10.1177/0271678X16668536

DO - 10.1177/0271678X16668536

M3 - Journal article

C2 - 27629099

SP - 2333

EP - 2440

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 37(7)

ER -