Joel Fredrik Astrup Aanerud

Data-driven intensity normalization of PET group comparison studies is superior to global mean normalization

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Global mean (GM) normalization is one of the most commonly used methods of normalization in PET and SPECT group comparison studies of neurodegenerative disorders. It requires that no between-group GM difference is present, which may be strongly violated in neurodegenerative disorders. Importantly, such GM differences often elude detection due to the large intrinsic variance in absolute values of cerebral blood flow or glucose consumption. Alternative methods of normalization are needed for this type of data.
Original languageEnglish
Pages (from-to)981-8
Number of pages8
Publication statusPublished - 2009

    Research areas

  • Adult, Aged, Brain, Brain Mapping, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Positron-Emission Tomography

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