Research output per year
Research output per year
Research output
- 24 Journal article
- 24 results
Search results
-
2025
Natural Design of a Stabilized Cross-β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats
Peña Díaz, S., Zhang, Z., Jiang, Y., Daugberg, A. O. H., López Hernández, M., Nielsen, J., Dueholm, M. K. D., Dong, M., Pedersen, J. S., Otzen, D. E. & Wang, H., 11 Jun 2025, (E-pub / Early view) In: Advanced Materials.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity
Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D., 5 Mar 2025, In: ACS Chemical Neuroscience. 16, 5, p. 880-894 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity
Shiraz, M. G., Nielsen, J., Widmann, J., Chung, K. H. K., Davis, T. P., Rasmussen, C., Scavenius, C., Enghild, J. J., Martin-Gallausiaux, C., Singh, Y., Javed, I. & Otzen, D. E., Jan 2025, In: Molecules and Cells. 48, 1, 100161.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
2024
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K., Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S., Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J. & Nielsen, M. A. & 3 others, , Jun 2024, In: npj Parkinson's Disease . 10, 1, 139.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access5 Citations (Scopus) -
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
Adam, L., Kumar, R., Arroyo-Garcia, L. E., Molenkamp, W. H., Nowak, J. S., Klute, H., Farzadfard, A., Alkenayeh, R., Nielsen, J., Biverstål, H., Otzen, D. E., Johansson, J. & Abelein, A., Aug 2024, In: Protein Science. 33, 8, 17 p., e5091.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
2023
4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation
Andersen, C. B., Lausdahl, A. K., Nielsen, J., Clausen, M. P., Mulder, F. A. A., Otzen, D. E. & Arnspang, E. C., 15 Aug 2023, In: Biochemistry. 62, 16, p. 2417-2425 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
4 Citations (Scopus) -
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions
Somavarapu, A. K., Kleijwegt, G., Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E., 21 Feb 2023, In: Chemical Science. 14, 11, p. 3030-3047 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
4 Citations (Scopus) -
Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces
Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T., Dec 2023, In: Nature Communications. 14, 1, 12 p., 5731.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access11 Citations (Scopus) -
GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureusreveal surface-associated coagulase in biofilms
Evans, D. C. S., Khamas, A. B., Marcussen, L., Rasmussen, K. S., Klitgaard, J. K., Kallipolitis, B. H., Nielsen, J., Otzen, D. E., Leake, M. C. & Meyer, R. L., Jul 2023, In: Microbial Cell. 10, 7, p. 145-156 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access6 Citations (Scopus) -
Tau Fibrillation Induced by Heparin or a Lysophospholipid Show Different Initial Oligomer Formation
Rasmussen, H. Ø., Nielsen, J., de Poli, A., Otzen, D. E. & Pedersen, J. S., Sept 2023, In: Journal of Molecular Biology. 435, 17, 18 p., 168194.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)4 Downloads (Pure) -
2022
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaite, V., Gupta, A., Strømgaard, K., Andreasen, M., Sharma, D., Saboury, A. A. & Otzen, D. E., Dec 2022, In: Journal of Biological Chemistry. 298, 12, 102688.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access6 Citations (Scopus) -
Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition
Farzadfard, A., König, A., Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F. & Otzen, D. E., 1 May 2022, In: The Journal of Biological Chemistry. 298, 5, 14 p., 101848.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access30 Citations (Scopus) -
Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation.
Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Pedersen, J. S., Nielsen, J. & Otzen, D. E., Jan 2022, In: BBA advances. 2, 100055.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein
Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J.-Y. & Jensen, P. H., Mar 2022, In: Scientific Reports. 12, 3737.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access10 Citations (Scopus) -
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers
Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S., 2022, In: Fluids and Barriers of the CNS. 19, 1, 12 p., 37.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access16 Citations (Scopus) -
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization
Sahin, C., Østerlund, E. C., Österlund, N., Costeira-Paulo, J., Pedersen, J. N., Christiansen, G., Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, M. J., Ilag, L. L., Davies, M. J., Marklund, E. G., Pedersen, J. S., Landreh, M., Møller, I. M., Jørgensen, T. J. D. & Otzen, D. E., Jul 2022, In: Journal of the American Chemical Society. 144, 27, p. 11949-11954 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile12 Citations (Scopus)30 Downloads (Pure) -
2021
How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein
Andersen, C. B., Yoshimura, Y., Nielsen, J., Otzen, D. E. & Mulder, F. A. A., 2021, In: The Journal of Biological Chemistry. 296, 10 p., 100788.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access13 Citations (Scopus) -
Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus
Najarzadeh, Z., Nielsen, J., Farzadfard, A., Sereikaite, V., Strømgaard, K., Meyer, R. L. & Otzen, D. E., Aug 2021, In: ACS Omega. 6, 34, p. 21960-21970 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access9 Citations (Scopus) -
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications
Andersen, C., Grønnemose, A. L., Pedersen, J. N., Nowak, J. S., Christiansen, G., Nielsen, J., Mulder, F. A. A., Otzen, D. E. & Jørgensen, T. J. D., 30 Nov 2021, In: Biochemistry. 60, 47, p. 3644-3658 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
17 Citations (Scopus) -
Molecular characteristics of porcine alpha-synuclein splicing variants
Larsen, K., Bæk, R., Sahin, C., Kjær, L., Christiansen, G., Nielsen, J., Farajzadeh, L. & Otzen, D. E., Jan 2021, In: Biochimie. 180, p. 121-133 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
3 Citations (Scopus) -
2020
SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence
Krainer, G., Hartmann, A., Bogatyr, V., Nielsen, J., Schlierf, M. & Otzen, D. E., Sept 2020, In: Chemical Science. 11, 34, p. 9141-9153 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access17 Citations (Scopus) -
The interactome of stabilized α-synuclein oligomers and neuronal proteins
van Diggelen, F., Frank, S. A., Somavarapu, A. K., Scavenius, C., Apetri, M. M., Nielsen, J., Tepper, A. W. J. W., Enghild, J. J. & Otzen, D. E., 1 May 2020, In: FEBS journal. 287, 10, p. 2037-2054 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
12 Citations (Scopus) -
2019
Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation
Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G. & Otzen, D. E., Feb 2019, In: ACS Omega. 4, 2, p. 4029-4039 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
37 Citations (Scopus) -
2018
Using Liprotides to Deliver Cholesterol to the Plasma Membrane
Frislev, H. S., Nielsen, J., Nylandsted, J. & Otzen, D., 1 Aug 2018, In: Journal of Membrane Biology. 25, 4, p. 581-592 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
5 Citations (Scopus)