Jørgen Frøkiær

2024

Quantitative and qualitative comparison of Rubidium-82 and Oxygen-15 water cardiac PET

Hoff, C. M., Sørensen, J., Kero, T., Bouchelouche, K., Harms, H., Frøkiær, J., Gormsen, L. C. & Tolbod, L. P., 28 Feb 2024, In: Journal of Nuclear Cardiology. 32, p. 101796 1 p., 101796.

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Open Access

2023

Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis

Nørregaard, R., Mutsaers, H. A. M., Frøkiær, J. & Kwon, T. H., Oct 2023, In: Physiological Reviews. 103, 4, p. 2827-2872 46 p.

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Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR

Munch, P. V., Heide-Jørgensen, U., Jensen, S. K., Birn, H., Vestergaard, S. V., Frøkiær, J., Sørensen, H. T. & Christiansen, C. F., Dec 2023, In: Clinical Kidney Journal. 16, 12, p. 2728-2737 10 p.

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Open Access

2022

Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?

Rehling, M., Skjøth, S. G., Frøkiær, J., Nielsen, L. E., Flø, C., Jespersen, B. & Keller, A. K., 2022, In: BMC Nephrology. 23, 1, 5 p., 146.

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Open Access

Myocardial efficiency in patients with different aetiologies and stages of heart failure

Hansen, K. B., Sörensen, J., Hansson, N. H., Nielsen, R., Larsen, A. H., Frøkiær, J., Tolbod, L. P., Gormsen, L. C., Harms, H. J. & Wiggers, H., Mar 2022, In: European Heart Journal Cardiovascular Imaging. 23, 3, p. 328-337 10 p.

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The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo

Engbjerg, J. S., Costanzo, V., Sardella, D., Bordoni, L., Jakobsen, S., D'Apolito, L., Frøkiær, J., Trepiccione, F., Capasso, G. & Frische, S., Mar 2022, In: Molecular Imaging. 2022, 10 p., 7908357.

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Open Access

2021

A nonbiodegradable scaffold-free cell sheet of genome-engineered mesenchymal stem cells inhibits development of acute kidney injury

Park, H. J., Kong, M. J., Jang, H. J., Cho, J. I., Park, E. J., Lee, I. K., Frøkiær, J., Norregaard, R., Park, K. M. & Kwon, T. H., Jan 2021, In: Kidney International. 99, 1, p. 117-133 17 p.

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1 Citation (Scopus)

Metformin Lowers Body Weight But Fails to Increase Insulin Sensitivity in Chronic Heart Failure Patients without Diabetes: a Randomized, Double-Blind, Placebo-Controlled Study

Larsen, A. H., Wiggers, H., Dollerup, O. L., Jespersen, N. R., Hansson, N. H., Frøkiær, J., Brøsen, K., Nørrelund, H., Bøtker, H. E., Møller, N. & Jessen, N., Jun 2021, In: Cardiovascular Drugs and Therapy. 35, 3, p. 491-503 13 p.

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Potential synergy between PSMA uptake and tumour blood flow for prediction of human prostate cancer aggressiveness

Jochumsen, M. R., Sörensen, J., Tolbod, L. P., Pedersen, B. G., Frøkiær, J., Borre, M. & Bouchelouche, K., Feb 2021, In: EJNMMI research. 11, 11 p., 12.

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Open Access

Risk factors for kidney scarring and vesicoureteral reflux in 421 children after their first acute pyelonephritis, and appraisal of international guidelines

Breinbjerg, A., Jørgensen, C. S., Frøkiær, J., Tullus, K., Kamperis, K. & Rittig, S., Sept 2021, In: Pediatric nephrology (Berlin, Germany). 36, 9, p. 2777-2787 11 p.

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Tumour blood flow for prediction of human prostate cancer aggressiveness - A study with Rubidium-82 PET, MRI and Na+/K+-ATPase-density

Jochumsen, M. R., Sørensen, J., Pedersen, B. G., Nyengaard, J. R., Krag, S. R. P., Frøkiær, J., Borre, M., Bouchelouche, K. & Tolbod, L. P., Feb 2021, In: European Journal of Nuclear Medicine and Molecular Imaging. 48, 2, p. 532-542 11 p.

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2020

A novel neurodegenerative spectrum disorder in patients with MLKL deficiency

Faergeman, S. L., Evans, H., Attfield, K. E., Desel, C., Kuttikkatte, S. B., Sommerlund, M., Jensen, L. T., Frokiaer, J., Friese, M. A., Matthews, P. M., Luchtenborg, C., Brügger, B., Oturai, A. B., Dendrou, C. A. & Fugger, L., May 2020, In: Cell Death and Disease. 11, 303.

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Open Access

A randomised, double-blind, placebo-controlled trial of metformin on myocardial efficiency in insulin-resistant chronic heart failure patients without diabetes

Larsen, A. H., Jessen, N., Nørrelund, H., Tolbod, L. P., Harms, H. J., Feddersen, S., Nielsen, F., Brøsen, K., Hansson, N. H., Frøkiaer, J., Poulsen, S. H., Sörensen, J. & Wiggers, H., Sept 2020, In: European Journal of Heart Failure. 22, 9, p. 1628-1637 10 p.

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Citrate NMR peak irreproducibility in blood samples after reacquisition of spectra

Hanifa, M. A., Maltesen, R. G., Rasmussen, B. S., Buggeskov, K. B., Ravn, H. B., Skott, M., Nielsen, S., Frøkiær, J., Ring, T. & Wimmer, R., Jan 2020, In: Metabolomics. 16, 1, 7 p., 7.

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Metformin is distributed to tumor tissue in breast cancer patients in vivo: A ¹¹C-metformin PET/CT study

Sundelin, E. I. O., al-Suliman, N., Vahl, P., Vendelbo, M., Munk, O. L., Jakobsen, S., Pedersen, S. B., Frøkiær, J., Gormsen, L. C. & Jessen, N., May 2020, In: Breast Cancer Research and Treatment. 181, 1, p. 107-113 7 p.

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Pilot Study Experiences With Hyperpolarized [1-¹³C]pyruvate MRI in Pancreatic Cancer Patients

Stødkilde-Jørgensen, H., Laustsen, C., Hansen, E. S. S., Schulte, R., Ardenkjaer-Larsen, J. H., Comment, A., Frøkiaer, J., Ringgaard, S., Bertelsen, L. B., Ladekarl, M. & Weber, B., 1 Mar 2020, In: Journal of Magnetic Resonance Imaging. 51, 3, p. 961-963 3 p.

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Prostate ⁸²Rb PET tumor blood flow measurement for detection of significant prostate cancer

Jochumsen, M. R., Tolbod, L. P., Pedersen, B. G., Frøkiær, J., Borre, M., Bouchelouche, K. & Sørensen, J., May 2020, In: Journal of Nuclear Medicine. 61, 189

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Renal potassium excretion visualized on ⁸²Rubidium PET/CT

Jochumsen, M. R., Tolbod, L. P., Borre, M., Frøkiær, J., Bouchelouche, K. & Sørensen, J., Apr 2020, In: Nuclear Medicine and Molecular Imaging. 54, 2, p. 120-122 3 p.

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Open Access

Tissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Hanifa, M. A., Skott, M., Maltesen, R. G., Rasmussen, B. S., Nielsen, S., Frøkiær, J., Ring, T. & Wimmer, R., Dec 2020, In: Data in Brief. 33, 106567.

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Open Access

2019

¹⁸Fluorodeoxyglucose Accumulation in Arterial Tissues Determined by PET Signal Analysis

Al-Mashhadi, R. H., Tolbod, L. P., Bloch, L., Bjørklund, M. M., Nasr, Z. P., Al-Mashhadi, Z., Winterdahl, M., Frøkiær, J., Falk, E. & Bentzon, J. F., 2019, In: Journal of the American College of Cardiology. 74, 9, p. 1220-1232 13 p.

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Open Access

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1 Citation (Scopus)

82 Downloads (Pure)

Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

Nielsen, R., Møller, N., Gormsen, L. C., Tolbod, L. P., Hansson, N. H., Sorensen, J., Harms, H. J., Frøkiær, J., Eiskjaer, H., Jespersen, N. R., Mellemkjaer, S., Lassen, T. R., Pryds, K., Bøtker, H. E. & Wiggers, H., Apr 2019, In: Circulation. 139, 18, p. 2129-2141 13 p.

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High repeatability of dynamic ⁸²Rubidium-PET/CT for tumor blood flow imaging in prostate cancer - a test-retest study

Jochumsen, M. R., Bouchelouche, K., Nielsen, K. B., Borre, M., Frøkiær, J., Sørensen, J. & Tolbod, L. P., Oct 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46, Suppl 1, p. S278-S279 2 p., OP-728.

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Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction

Schelde, A. B., Schmidt, M., Madsen, M., Nielsen, S. S., Frøkiær, J. & Christiansen, C. F., 2019, In: Clinical epidemiology. 11, p. 901-910 10 p.

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Open Access

Quantitative Estimation of Extravascular Lung Water Volume and Preload by dynamic 15O-water Positron Emission Tomography

Nielsen, B. R. R., Sørensen, J., Tolbod, L. P., Alstrup, A. K. O., Iversen, P., Frederiksen, C. A., Wiggers, H., Jorsal, A., Frøkiær, J. & Harms, H., 18 Mar 2019, In: European Heart Journal Cardiovascular Imaging. 20, 10, p. 1120-1128 9 p.

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Quantitative Tumor Perfusion Imaging with 82Rb PET/CT in Prostate Cancer: Analytic and Clinical Validation

Jochumsen, M. R., Tolbod, L. P., Pedersen, B. G., Nielsen, M. M., Hoyer, S., Frokiaer, J., Borre, M., Bouchelouche, K. & Sorensen, J., Aug 2019, In: Journal of Nuclear Medicine. 60, 8, p. 1059-1065 7 p.

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Repeatability of static 82Rubidium PET for tumor blood flow imaging in prostate cancer - a test-retest study

Jochumsen, M. R., Bouchelouche, K., Borre, M., Frøkiær, J., Sørensen, J. & Tolbod, L. P., 24 Jun 2019.

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Repeatability of tumor blood flow quantification with ⁸²Rubidium-PET/CT in prostate cancer - a test-retest study

Jochumsen, M. R., Bouchelouche, K., Nielsen, K. B., Frøkiær, J., Borre, M., Sørensen, J. & Tolbod, L. P., 2019, In: EJNMMI Research. 9, 58, 7 p., 58.

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Open Access

Test-retest study of tumor blood flow quantification with 82Rubidium-PET/CT in prostate cancer

Jochumsen, M. R., Bouchelouche, K., Borre, M., Frøkiær, J., Sørensen, J. & Tolbod, L. P., 2019, In: Journal of Nuclear Medicine. 60, 1556.

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Open Access

The relationship between tumor aggressiveness and cholinergic PET imaging in prostate cancer tissue. A proof-of-concept study

Nielsen, M. M., Tolbod, L. P., Borre, M., Høyer, S., Harms, H. J., Sørensen, J., Frøkiær, J. & Borghammer, P., 2019, In: American Journal of Nuclear Medicine and Molecular Imaging. 9, 3, p. 185-192 8 p.

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Tissue, urine and blood metabolite signatures of chronic kidney disease in the 5/6 nephrectomy rat model

Hanifa, M. A., Skott, M., Maltesen, R. G., Rasmussen, B. S., Nielsen, S., Frøkiær, J., Ring, T. & Wimmer, R., Aug 2019, In: Metabolomics. 15, 8, 112.

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Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Tingskov, S. J., Choi, H.-J., Holst, M. R., Hu, S., Li, C., Wang, W., Frokiaer, J., Nejsum, L. N., Kwon, T.-H. & Norregaard, R., Aug 2019, In: Frontiers in Physiology. 10, JUL, p. 1-13 13 p., 948.

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2018

APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells

Jacobsen, K. M., Villadsen, N. L., Tørring, T., Nielsen, C. B., Salomón, T., Nielsen, M. M., Tsakos, M., Sibbersen, C., Scavenius, C., Nielsen, R., Christensen, E. I., Guerra, P. F., Bross, P., Pedersen, J. S., Enghild, J. J., Johannsen, M., Frøkiær, J., Overgaard, J., Horsman, M. R. & Busk, M. & 1 others, Poulsen, T. B., Nov 2018, In: Cell Chemical Biology. 25, 11, p. 1337-1349.e12 13 p.

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A proof-of-concept study of quantitative tumor perfusion imaging with 82Rb PET/CT in Prostate Cancer

Jochumsen, M. R., Tolbod, L. P., Pedersen, B. G., Borre, M., Frøkiær, J., Bouchelouche, K. & Sørensen, J., May 2018, In: The Journal of Nuclear Medicine. 59, supplement 1 1473

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Open Access

A proof-of-concept study of quantitative tumor perfusion imaging with 82Rb PET/CT in Prostate Cancer

Jochumsen, M. R., Tolbod, L. P., Pedersen, B. G., Borre, M., Frøkiær, J., Bouchelouche, K. & Sørensen, J., Jun 2018.

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Assessment of very early response evaluation with F-FDG-PET/CT predicts survival in erlotinib treated NSCLC patients-A comparison of methods

Fledelius, J., Winther-Larsen, A., Khalil, A. A., Hjorthaug, K., Frøkiær, J. & Meldgaard, P., 2018, In: American Journal of Nuclear Medicine and Molecular Imaging. 8, 1, p. 50-61 12 p.

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Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan

Harms, H., Stubkjær Hansson, N. H., Kero, T., Baron, T., Tolbod, L. P., Kim, W. Y., Frøkiær, J., Flachskampf, F. A., Wiggers, H. & Sørensen, J., 26 Jun 2018, In: Journal of Nuclear Cardiology. 25, 6, p. 1-8 8 p.

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Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: An experimental porcine study

Thomassen, S. A., Kjaergaard, B., Alstrup, A. K. O., Munk, O. L., Frøkiær, J., Larsson, A. & Rasmussen, B. S., 30 Jan 2018, In: Perfusion. 33, 5, p. 346-353 8 p.

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Effect of remote ischemic conditioning on myocardial perfusion in patients with suspected ischemic coronary artery disease

Pryds, K., Nielsen, R. R., Hoff, C. M., Tolbod, L. P., Bouchelouche, K., Li, J., Schmidt, M. R., Redington, A. N., Frøkiær, J. & Bøtker, H. E., Jun 2018, In: Journal of Nuclear Cardiology. 25, 3, p. 887-896 10 p.

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Non-invasive quantification of tumor blood flow in prostate cancer using 15O-H2O PET/CT

Tolbod, L. P., Nielsen, M. M., Pedersen, B. G., Høyer, S., Harms, H., Borre, M., Borghammer, P., Bouchelouche, K., Frøkiær, J. & Sørensen, J., 2018, In: American Journal of Nuclear Medicine and Molecular Imaging. 8, 5, p. 292-302 11 p.

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Publisher Correction: Hyperpolarized [1-C]-acetate Renal Metabolic Clearance Rate Mapping

Mikkelsen, E. F. R., Mariager, C. Ø., Nørlinger, T., Qi, H., Schulte, R. F., Jakobsen, S., Frøkiær, J., Pedersen, M., Stødkilde-Jørgensen, H. & Laustsen, C., 20 Jul 2018, In: Scientific Reports. 8, 1, p. 11235

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Quantitative Estimation of Extravascular Lung Water Volume and Preload by dynamic 15O-water Positron Emission Tomography

Nielsen, B. R. R., Sørensen, J., Tolbod, L. P., Alstrup, A. K. O., Iversen, P., Frederiksen, C. A., Frøkiær, J. & Harms, H. J., 23 Jun 2018.

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Tamoxifen attenuates development of lithium-induced nephrogenic diabetes insipidus in rats

Tingskov, S. J., Hu, S., Frøkiær, J., Kwon, T.-H., Wang, W. & Norregaard, R., May 2018, In: American Journal of Physiology: Renal Physiology. 314, 5, p. F1020-F1025 6 p.

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Tamoxifen decreases lithium-induced natriuresis in rats with nephrogenic diabetes insipidus

Tingskov, S. J., Kwon, T. H., Frøkiaer, J. & Nørregaard, R., 12 Jul 2018, In: Frontiers in Physiology. 9, JUL, 903.

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Test-retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic C-acetate PET and multimodality approaches in healthy controls

Hansson, N. H., Harms, H. J., Kim, W. Y., Nielsen, R., Tolbod, L. P., Frøkiær, J., Bouchelouche, K., Poulsen, S. H., Wiggers, H., Parner, E. T. & Sörensen, J., Dec 2018, In: Journal of Nuclear Cardiology. 25, 6, p. 1929-1936 8 p.

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2017

(18)F-FDG-PET/CT for very early response evaluation predicts CT response in Erlotinib treated NSCLC patients - A comparison of assessment methods

Fledelius, J., Winther-Larsen, A., Khalil, A. A., Bylov, C. M., Hjorthaug, K., Bertelsen, A., Frøkiær, J. & Meldgaard, P., 1 Dec 2017, In: Journal of Nuclear Medicine. 58, 12, p. 1931-1937 7 p.

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82Rb Cardiac PET in patients with known ischemic heart disease – a direct comparison with 15O-water Cardiac PET

Hoff, C. M., Tolbod, L. P., Harms, H., Sørensen, J., Frøkiær, J. & Bouchelouche, K., 1 May 2017, In: Journal of Nuclear Medicine. 58, suppl 1 373

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Arterial Clamping Increases Central Renal Cryoablation Efficacy: An Animal Study

Nonboe, L. L., Nielsen, T. K., Høyer, S., Graumann, O., Frøkiær, J. & Borre, M., Aug 2017, In: Technology in Cancer Research and Treatment. 16, 4, p. 414-420 7 p.

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FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach

Busk, M., Munk, O. L., Jakobsen, S., Frøkiær, J., Overgaard, J. & Horsman, M. R., May 2017, In: Acta Oncologica. 56, 5, p. 706-712 7 p.

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Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans

Sundelin, E., Gormsen, L. C., Jensen, J. B., Vendelbo, M. H., Jakobsen, S., Munk, O. L., Christensen, M. M. H., Brøsen, K., Frøkiaer, J. & Jessen, N., Nov 2017, In: Clinical Pharmacology and Therapeutics. 102, 5, p. 841-848 8 p.

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Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping

Mikkelsen, E. F. R., Mariager, C. Ø., Nørlinger, T., Qi, H., Schulte, R. F., Jakobsen, S., Frøkiær, J., Pedersen, M., Stødkilde-Jørgensen, H. & Laustsen, C., 22 Nov 2017, In: Scientific Reports. 7, 1, p. 16002 9 p., 16002.

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Jørgen Frøkiær

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