Jesper Weile

Focused lung ultrasound to predict respiratory failure in patients with symptoms of COVID-19: a multicentre prospective cohort study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Søren Helbo Skaarup
  • Rasmus Aagaard
  • Stig Holm Ovesen
  • Jesper Weile
  • Hans Kirkegaard
  • Caroline Espersen, University of Copenhagen
  • ,
  • Mats Christian Højbjerg Lassen, University of Copenhagen
  • ,
  • Kristoffer Grundtvig Skaarup, University of Copenhagen
  • ,
  • Stefan Posth, University of Southern Denmark
  • ,
  • Christian B. Laursen, University of Southern Denmark
  • ,
  • Ask Bock, University of Copenhagen, University of Southern Denmark
  • ,
  • Michael Dan Arvig, University of Southern Denmark, University of Copenhagen
  • ,
  • Tor Biering-Sørensen, University of Copenhagen

Background In this study we aimed to assess if a focused lung ultrasound examination predicts the need for mechanical ventilation, admission to an intensive care unit, high-flow oxygen treatment, death from COVID-19 within 30 days and 30-day all-cause mortality in patients with clinical suspicion of COVID-19 or PCR-verified SARS-CoV-2 infection. Methods A multicentre prospective cohort trial was performed. Film clips from focused lung ultrasound examinations were recorded and rated by blinded observers using different scoring systems. A prediction model was built and used to test relationship between lung ultrasound scores and clinical outcomes. Diagnostic performance of scoring systems was analysed. Results A total of 3889 film clips of 398 patients were analysed. Patients who had any of the outcomes of interest had a significantly higher ultrasound score than those who did not. Multivariable logistic regression analyses showed that lung ultrasound predicts mechanical ventilation (relative risk 2.44, 95% CI 1.32–5.52), admission to intensive care (relative risk 2.55, 95% CI 1.41–54.59) and high-flow oxygen treatment (relative risk 1.95, 95% CI 1.5–2.53) but not survival when adjusting for sex, age and relevant comorbidity. There was no diagnostic difference in area under the receiver operating characteristic curve between a scoring system using only anterolateral thorax zones and a scoring system that also included dorsal zones. Conclusion Focused lung ultrasound in patients with clinical suspicion of COVID-19 predicts respiratory failure requiring mechanical ventilation, admission to intensive care units and the need for high-flow oxygen treatment. Thus, focused lung ultrasound may be used to risk stratify patients with COVID-19 symptoms.

Original languageEnglish
Article number00128-2022
JournalERJ Open Research
Publication statusPublished - Oct 2022

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