Jesper Møller Jensen

Prognostic assessment of stable coronary artery disease as determined by coronary computed tomography angiography: a Danish multicentre cohort study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


  • Lene H Nielsen, Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark
  • ,
  • Hans Erik Bøtker
  • Henrik T Sørensen
  • Morten Schmidt
  • Lars Pedersen
  • Niels Peter Sand, University of Southern Denmark
  • ,
  • Jesper Møller Jensen
  • Flemming H Steffensen, Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
  • ,
  • Hans Henrik Tilsted, Aalborg University
  • ,
  • Morten Bøttcher
  • Axel Diederichsen, University of Southern Denmark
  • ,
  • Jess Lambrechtsen, University of Southern Denmark
  • ,
  • Lone D Kristensen
  • ,
  • Kristian A Øvrehus
  • ,
  • Hans Mickley, University of Southern Denmark
  • ,
  • Henrik Munkholm, Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
  • ,
  • Ole Gøtzsche
  • ,
  • Majed Husain, University of Southern Denmark
  • ,
  • Lars L Knudsen
  • ,
  • Bjarne L Nørgaard

AIMS: To examine the 3.5 year prognosis of stable coronary artery disease (CAD) as assessed by coronary computed tomography angiography (CCTA) in real-world clinical practice, overall and within subgroups of patients according to age, sex, and comorbidity.

METHODS AND RESULTS: This cohort study included 16,949 patients (median age 57 years; 57% women) with new-onset symptoms suggestive of CAD, who underwent CCTA between January 2008 and December 2012. The endpoint was a composite of late coronary revascularization procedure >90 days after CCTA, myocardial infarction, and all-cause death. The Kaplan-Meier estimator was used to compute 91 day to 3.5 year risk according to the CAD severity. Comparisons between patients with and without CAD were based on Cox-regression adjusted for age, sex, comorbidity, cardiovascular risk factors, concomitant cardiac medications, and post-CCTA treatment within 90 days. The composite endpoint occurred in 486 patients. Risk of the composite endpoint was 1.5% for patients without CAD, 6.8% for obstructive CAD, and 15% for three-vessel/left main disease. Compared with patients without CAD, higher relative risk of the composite endpoint was observed for non-obstructive CAD [hazard ratio (HR): 1.28; 95% confidence interval (CI): 1.01-1.63], obstructive one-vessel CAD (HR: 1.83; 95% CI: 1.37-2.44), two-vessel CAD (HR: 2.97; 95% CI: 2.09-4.22), and three-vessel/left main CAD (HR: 4.41; 95% CI :2.90-6.69). The results were consistent in strata of age, sex, and comorbidity.

CONCLUSION: Coronary artery disease determined by CCTA in real-world practice predicts the 3.5 year composite risk of late revascularization, myocardial infarction, and all-cause death across different groups of age, sex, or comorbidity burden.

Original languageEnglish
JournalEuropean Heart Journal
Pages (from-to)413–421
Publication statusPublished - 2017

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