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Department of Clinical Medicine

Jesper Møller Jensen

Coronary volume to left ventricular mass ratio in patients with diabetes mellitus

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Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. / Kuneman, Jurrien H; El Mahdiui, Mohammed; van Rosendael, Alexander R et al.
In: Journal of Cardiovascular Computed Tomography, Vol. 16, No. 4, 07.2022, p. 319-326.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Kuneman, JH, El Mahdiui, M, van Rosendael, AR, van den Hoogen, IJ, Patel, MR, Nørgaard, BL, Fairbairn, TA, Nieman, K, Akasaka, T, Berman, DS, Hurwitz Koweek, LM, Pontone, G, Kawasaki, T, Rønnow Sand, NP, Jensen, JM, Amano, T, Poon, M, Øvrehus, KA, Sonck, J, Rabbat, MG, De Bruyne, B, Rogers, C, Matsuo, H, Bax, JJ, Leipsic, JA & Knuuti, J 2022, 'Coronary volume to left ventricular mass ratio in patients with diabetes mellitus', Journal of Cardiovascular Computed Tomography, vol. 16, no. 4, pp. 319-326. https://doi.org/10.1016/j.jcct.2022.01.004

APA

Kuneman, J. H., El Mahdiui, M., van Rosendael, A. R., van den Hoogen, I. J., Patel, M. R., Nørgaard, B. L., Fairbairn, T. A., Nieman, K., Akasaka, T., Berman, D. S., Hurwitz Koweek, L. M., Pontone, G., Kawasaki, T., Rønnow Sand, N. P., Jensen, J. M., Amano, T., Poon, M., Øvrehus, K. A., Sonck, J., ... Knuuti, J. (2022). Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. Journal of Cardiovascular Computed Tomography, 16(4), 319-326. https://doi.org/10.1016/j.jcct.2022.01.004

CBE

Kuneman JH, El Mahdiui M, van Rosendael AR, van den Hoogen IJ, Patel MR, Nørgaard BL, Fairbairn TA, Nieman K, Akasaka T, Berman DS, et al. 2022. Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. Journal of Cardiovascular Computed Tomography. 16(4):319-326. https://doi.org/10.1016/j.jcct.2022.01.004

MLA

Kuneman, Jurrien H et al. "Coronary volume to left ventricular mass ratio in patients with diabetes mellitus". Journal of Cardiovascular Computed Tomography. 2022, 16(4). 319-326. https://doi.org/10.1016/j.jcct.2022.01.004

Vancouver

Kuneman JH, El Mahdiui M, van Rosendael AR, van den Hoogen IJ, Patel MR, Nørgaard BL et al. Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. Journal of Cardiovascular Computed Tomography. 2022 Jul;16(4):319-326. Epub 2022 Feb 1. doi: 10.1016/j.jcct.2022.01.004

Author

Kuneman, Jurrien H ; El Mahdiui, Mohammed ; van Rosendael, Alexander R et al. / Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. In: Journal of Cardiovascular Computed Tomography. 2022 ; Vol. 16, No. 4. pp. 319-326.

Bibtex

@article{d741d7e36c554db39fc79cff30f792d4,

title = "Coronary volume to left ventricular mass ratio in patients with diabetes mellitus",

abstract = "BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.RESULTS: Of the 3053 patients (age 66 ± 10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ± 940 mm3 vs. 3040 ± 970 mm3, p < 0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ± 33 g vs. 122 ± 32 g, p = 0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ± 6.8 mm3/g vs. 25.7 ± 7.5 mm3/g, p < 0.0001). Among subjects with obstructive CAD (n = 2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ± 6.7 mm3/g vs. 25.0 ± 7.3 mm3/g, p < 0.0001 and 25.6 ± 6.9 mm3/g vs. 27.3 ± 7.6 mm3/g, respectively, p = 0.006).CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.",

keywords = "Coronary artery disease, Coronary computed tomography angiography, Coronary volume, Diabetes mellitus, Left ventricular mass, Volume to mass ratio",

author = "Kuneman, {Jurrien H} and {El Mahdiui}, Mohammed and {van Rosendael}, {Alexander R} and {van den Hoogen}, {Inge J} and Patel, {Manesh R} and N{\o}rgaard, {Bjarne Linde} and Fairbairn, {Timothy A} and Koen Nieman and Takashi Akasaka and Berman, {Daniel S} and {Hurwitz Koweek}, {Lynne M} and Gianluca Pontone and Tomohiro Kawasaki and {R{\o}nnow Sand}, {Niels Peter} and Jensen, {Jesper M} and Tetsuya Amano and Michael Poon and {\O}vrehus, {Kristian A} and Jeroen Sonck and Rabbat, {Mark G} and {De Bruyne}, Bernard and Campbell Rogers and Hitoshi Matsuo and Bax, {Jeroen J} and Leipsic, {Jonathon A} and Juhani Knuuti",

year = "2022",

month = jul,

doi = "10.1016/j.jcct.2022.01.004",

language = "English",

volume = "16",

pages = "319--326",

journal = "Journal of Cardiovascular Computed Tomography",

issn = "1934-5925",

publisher = "Elsevier Inc.",

number = "4",

}

RIS

TY - JOUR

T1 - Coronary volume to left ventricular mass ratio in patients with diabetes mellitus

AU - Kuneman, Jurrien H

AU - El Mahdiui, Mohammed

AU - van Rosendael, Alexander R

AU - van den Hoogen, Inge J

AU - Patel, Manesh R

AU - Nørgaard, Bjarne Linde

AU - Fairbairn, Timothy A

AU - Nieman, Koen

AU - Akasaka, Takashi

AU - Berman, Daniel S

AU - Hurwitz Koweek, Lynne M

AU - Pontone, Gianluca

AU - Kawasaki, Tomohiro

AU - Rønnow Sand, Niels Peter

AU - Jensen, Jesper M

AU - Amano, Tetsuya

AU - Poon, Michael

AU - Øvrehus, Kristian A

AU - Sonck, Jeroen

AU - Rabbat, Mark G

AU - De Bruyne, Bernard

AU - Rogers, Campbell

AU - Matsuo, Hitoshi

AU - Bax, Jeroen J

AU - Leipsic, Jonathon A

AU - Knuuti, Juhani

PY - 2022/7

Y1 - 2022/7

N2 - BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.RESULTS: Of the 3053 patients (age 66 ± 10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ± 940 mm3 vs. 3040 ± 970 mm3, p < 0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ± 33 g vs. 122 ± 32 g, p = 0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ± 6.8 mm3/g vs. 25.7 ± 7.5 mm3/g, p < 0.0001). Among subjects with obstructive CAD (n = 2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ± 6.7 mm3/g vs. 25.0 ± 7.3 mm3/g, p < 0.0001 and 25.6 ± 6.9 mm3/g vs. 27.3 ± 7.6 mm3/g, respectively, p = 0.006).CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.

AB - BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.RESULTS: Of the 3053 patients (age 66 ± 10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ± 940 mm3 vs. 3040 ± 970 mm3, p < 0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ± 33 g vs. 122 ± 32 g, p = 0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ± 6.8 mm3/g vs. 25.7 ± 7.5 mm3/g, p < 0.0001). Among subjects with obstructive CAD (n = 2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ± 6.7 mm3/g vs. 25.0 ± 7.3 mm3/g, p < 0.0001 and 25.6 ± 6.9 mm3/g vs. 27.3 ± 7.6 mm3/g, respectively, p = 0.006).CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.

KW - Coronary artery disease

KW - Coronary computed tomography angiography

KW - Coronary volume

KW - Diabetes mellitus

KW - Left ventricular mass

KW - Volume to mass ratio

U2 - 10.1016/j.jcct.2022.01.004

DO - 10.1016/j.jcct.2022.01.004

M3 - Journal article

C2 - 35190274

VL - 16

SP - 319

EP - 326

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

IS - 4

ER -