Jesper Falkesgaard Højen

  1. 2021
  2. E-pub ahead of print

    Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. / Gunst, Jesper D; Staerke, Nina B; Pahus, Marie H; Kristensen, Lena H; Bodilsen, Jacob; Lohse, Nicolai; Dalgaard, Lars S; Brønnum, Dorthe; Fröbert, Ole; Hønge, Bo; Johansen, Isik S; Monrad, Ida; Erikstrup, Christian; Rosendal, Regitze; Vilstrup, Emil; Mariager, Theis; Bove, Dorthe G; Offersen, Rasmus; Shakar, Shakil; Cajander, Sara; Jørgensen, Nis P; Sritharan, Sajitha S; Breining, Peter; Jespersen, Søren; Mortensen, Klaus L; Jensen, Mads L; Kolte, Lilian; Frattari, Giacomo S; Larsen, Carsten S; Storgaard, Merete; Nielsen, Lars P; Tolstrup, Martin; Sædder, Eva A; Østergaard, Lars J; Ngo, Hien T T; Jensen, Morten H; Højen, Jesper F; Kjolby, Mads; Søgaard, Ole S.

    In: EClinicalMedicine, 22.04.2021, p. 100849.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. E-pub ahead of print

    A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling. / Li, Suzhao; Jiang, Liqiong; Beckmann, Karsten; Højen, Jesper Falkesgaard; Pessara, Ulrich; Powers, Nicholas E; de Graaf, Dennis M; Azam, Tania; Lindenberger, Jared; Eisenmesser, Elan Z; Fischer, Stephan; Dinarello, Charles A.

    In: The Journal of Biological Chemistry, 03.04.2021, p. 100630.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety. / Breining, Peter; Frølund, Anne Lier; Højen, Jesper Falkesgaard; Gunst, Jesper Damsgaard; Staerke, Nina B; Saedder, Eva; Cases-Thomas, Manuel; Little, Paul; Nielsen, Lars Peter; Søgaard, Ole S; Kjolby, Mads.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 128, No. 2, 02.2021, p. 204-212.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  5. E-pub ahead of print

    SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses. / Vibholm, Line K; Nielsen, Stine Sf; Pahus, Marie H; Frattari, Giacomo S; Olesen, Rikke; Andersen, Rebecca; Monrad, Ida; Andersen, Anna H.F.; Thomsen, Michelle M; Konrad, Christina V; Andersen, Sidsel D; Højen, Jesper F; Gunst, Jesper D; Østergaard, Lars; Søgaard, Ole S; Schleimann, Mariane H; Tolstrup, Martin.

    In: EBioMedicine, Vol. 64, 30.01.2021, p. 103230.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2020
  7. Published

    Broadly neutralizing antibodies combined with latency-reversing agents or immune modulators as strategy for HIV-1 remission. / Gunst, Jesper Damsgaard; Højen, Jesper Falkesgaard; Søgaard, Ole Schmeltz.

    In: Current Opinion in HIV and AIDS, Vol. 15, No. 5, 09.2020, p. 309-315.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  8. Published

    The Use of Toll-Like Receptor Agonists in HIV-1 Cure Strategies. / Martinsen, Janne Tegder; Gunst, Jesper Damsgaard; Højen, Jesper Falkesgaard; Tolstrup, Martin; Søgaard, Ole Schmeltz.

    In: Frontiers in Immunology, Vol. 11, 1112, 06.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  9. 2019
  10. Published

    IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease. / Højen, Jesper Falkesgaard; Kristensen, Marie Louise Vindvad; McKee, Amy S.; Wade, Megan Taylor; Azam, Tania; Lunding, Lars P.; de Graaf, Dennis M.; Swartzwelter, Benjamin J.; Wegmann, Michael; Tolstrup, Martin; Beckman, Karsten; Fujita, Mayumi; Fischer, Stephan; Dinarello, Charles A.

    In: Nature Immunology, Vol. 20, No. 9, 2019, p. 1138-1149.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    cAIMP administration in humanized mice induces a chimerization-level-dependent STING response. / Andersen, Anna H.F.; Olesen, Rikke; Jønsson, Kasper L.; Højen, Jesper F.; Krapp, Christian; Mack, Katharina; Thomsen, Martin K.; Østergaard, Lars; Tolstrup, Martin; Dagnæs-Hansen, Frederik; Jakobsen, Martin R.; Denton, Paul W.

    In: Immunology, Vol. 157, No. 2, 2019, p. 163-172.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. 2018
  13. Published

    Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals. / Winckelmann, Anni; Morcilla, Vincent; Shao, Wei; Schleimann, Mariane H; Hojen, Jesper F; Schlub, Timothy E; Denton, Paul W; Østergaard, Lars; Søgaard, Ole S; Tolstrup, Martin; Palmer, Sarah.

    In: AIDS, Vol. 32, No. 13, 24.08.2018, p. 1793-1802.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Lipopolysaccharide-Induced Inflammatory Responses. / Brinkmann, Christel Rothe; Højen, Jesper Falkesgaard; Rasmussen, Thomas Aagaard; Kjær, Anne Sofie; Olesen, Rikke; Denton, Paul W; Østergaard, Lars; Ouyang, Zhengyu; Lichterfeld, Mathias; Yu, Xu; Søgaard, Ole Schmeltz; Dinarello, Charles; Tolstrup, Martin.

    In: mSphere, Vol. 3, No. 1, 23.02.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. 2017
  16. Published

    Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART) : Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs. / Tapia, G; Højen, J F; Ökvist, M; Olesen, R; Leth, S; Nissen, S K; VanBelzen, D J; O'Doherty, U; Mørk, A; Krogsgaard, K; Søgaard, O S; Østergaard, L; Tolstrup, M; Pantaleo, G; Sommerfelt, M A.

    In: The Journal of infection, 12.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Short-course TLR9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals with HIV infection. / Vibholm, Line; Schleimann, Mariane H; Højen, Jesper F; Benfield, Thomas; Offersen, Rasmus; Rasmussen, Katrine; Olesen, Rikke; Dige, Anders; Agnholt, Jørgen; Grau, Judith; Buzon, Maria J; Wittig, Burghardt; Lichterfeld, Mathias; Petersen, Andreas Munk; Deng, Xutao; Abdel-Mohsen, Mohammed; Pillai, Satish K; Rutsaert, Sofie; Trypsteen, Wim; De Spiegelaere, Ward; Vandekerchove, Linos; Østergaard, Lars Jørgen; Rasmussen, Thomas A; Denton, Paul W; Tolstrup, Martin; Søgaard, Ole S.

    In: Clinical Infectious Diseases, 15.06.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. 2016
  19. Published

    Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC) : a single-arm, phase 1B/2A trial. / Leth, Steffen; Schleimann, Mariane Høgsbjerg; Nissen, Sara K; Højen, Jesper F; Olesen, Rikke; Graversen, Mette E; Jorgensen, Sofie; Kjær, Anne Sofie; Denton, Paul W; Mørk, Alejandra; Sommerfelt, Maja A; Krogsgaard, Kim; Østergaard, Lars; Rasmussen, Thomas A; Tolstrup, Martin; Søgaard, Ole Schmeltz.

    In: Lancet HIV, Vol. 3, No. 10, 07.07.2016, p. e463–e472.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. 2015
  21. Published

    Interleukin-37 expression is increased in chronic HIV-1-infected individuals and is associated with inflammation and the size of the total viral reservoir. / Hansen, Jesper Falkesgaard; Rasmussen, Thomas A; Andersen, Karen Lise D; Winckelmann, Anni A; Laursen, Rune R; Damsgaard Gunst, Jesper; Møller, Holger J; Fujita, Mayumi; Østergaard, Lars Jørgen; Søgaard, Ole S; Dinarello, Charles A; Tolstrup, Martin.

    In: Molecular Medicine, 14.04.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. 2014
  23. Published

    Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation. / Nissen, Sara K; Højen, Jesper Falkesgaard; Andersen, Karen L D; Kofod-Olsen, Emil; Berg, Randi K; Paludan, Søren R; Ostergaard, Lars; Jakobsen, Martin Roelsgaard; Tolstrup, Martin; Mogensen, Trine H.

    In: Clinical and Experimental Immunology, Vol. 177, No. 1, 05.03.2014, p. 295-309.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review